Discovering multifaceted role of vanillic acid beyond flavours: Nutraceutical and therapeutic potential

Kaur, Jaskiran; Gulati, Monica; Singh, Sachin Kumar; Kuppusamy, Gowthamarajan; Kapoor, Bhupinder; Mishra, Vijay; Gupta, Saurabh; Arshad, Mohammed Faiz; Porwal, Omji; Jha, Niraj Kumar; Chaitanya, M.V.N.L.; Chellappan, Dinesh Kumar; Gupta, Gaurav; Gupta, Piyush Kumar; Dua, Kamal; Khursheed, Rubiya; Awasthi, Ankit; Corrie, Leander

doi:10.1016/j.tifs.2022.02.023

Cited by 89 publications

(54 citation statements)

References 84 publications

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“…Vanillic acid has an excellent antioxidant effect ( Kaur et al, 2022 ). Previous studies have proven that VA could regulate adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK- α2), nitric oxide synthase (eNOS), or endothelin 1 (ET1) to improve the oxidative stress injury of IR injury could also improve the symptoms in hypertensive rats ( Kumar et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…Vanillic acid (4-hydroxy-3-methoxybenzoicacid (VA) Figure 1 ), a cinnamic acid derivative, exists widely in nature and is found abundantly in several Chinese herbal medicines like Picrorhiza scrophulariiflora Pennell, Atractylodes macrocephala , and Coptis chinensis . VA has a strong antioxidant effect and demonstrates therapeutic potential against CVDs, which could reduce the production of intracellular ROS and reduce myocardial cell damage caused by hypoxia and reoxygenation ( Luo et al, 2020 ; Kaur et al, 2022 ). At present, research about VA effects on cardioprotective focuses on reducing apoptotic rate and lipid peroxidation ( Stanely Mainzen Prince et al, 2011 ), but there is lack of research studies on effects for mediating mitophagy.…”

Section: Introductionmentioning

confidence: 99%

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Vanillic acid attenuates H2O2-induced injury in H9c2 cells by regulating mitophagy via the PINK1/Parkin/Mfn2 signaling pathway

Mei

Sun²,

Xu³

et al. 2022

Front. Pharmacol.

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Vanillic acid, a phenolic compound mainly obtained from the foot of Picrorhiza scrophulariiflora Pennell, has been demonstrated to possess a cardiovascular-protective effect in previous studies. However, there is lack of research on vanillic acid protecting cardiomyocytes from oxidative stress injury by mediating mitophagy. In the present study, oxidative stress injury in the H9c2 cell line was induced by H2O2. Our results confirmed that vanillic acid mitigated apoptosis and injury triggered by oxidative stress, evidenced by the decline in production of reactive oxygen species and malondialdehyde and level of lactate dehydrogenase and the increase of superoxide dismutase and glutathione. The use of vanillic acid could also improve the polarization of mitochondrial membrane potential and decrease the cellular calcium level. After treatment by vanillic acid, impaired autophagy flux and mitophagy were improved, and the length of mitochondria was restored. Vanillic acid increased the expression of PINK1, Parkin, Mfn2, and the ratio of LC3-II/LC3-I and decreased the expression of p62. But, under the intervention of mitophagy inhibitor 3-MA, vanillic acid could not change the expression of PINK1/Parkin/Mfn2 and downstream genes to affect cell autophagy, mitophagy, and mitochondrial function. Our findings suggested that vanillic acid activated mitophagy to improve mitochondrial function, in which the PINK1/Parkin/Mfn2 pathway could be the potential regulatory mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vanillic acid attenuates H2O2-induced injury in H9c2 cells by regulating mitophagy via the PINK1/Parkin/Mfn2 signaling pathway

Mei

Sun²,

Xu³

et al. 2022

Front. Pharmacol.

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“…Vanillic acid exerts diverse bioactivity against cancer, diabetes, obesity, neurodegenerative, cardiovascular, and hepatic diseases by inhibiting the associated molecular pathways. Its derivatives also possess the therapeutic potential to treat autoimmune diseases, as well as fungal and bacterial infections [ 133 ]. Syringic acid shows a wide range of therapeutic applications in the prevention of diabetes, CVDs, cancer, and cerebral ischemia, as well as antioxidant, antimicrobial, anti-inflammatory, antiendotoxic, neurologic, and hepatoprotective activities [ 134 ].…”

Section: Resultsmentioning

confidence: 99%

Salt Eustress Induction in Red Amaranth (Amaranthus gangeticus) Augments Nutritional, Phenolic Acids and Antiradical Potential of Leaves

Sarker

Erċışlı

2022

Antioxidants

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Earlier researchers have highlighted the utilization of salt eustress for boosting the nutritional and phenolic acid (PA) profiles and antiradical potential (ARP) of vegetables, which eventually boost food values for nourishing human diets. Amaranth is a rapidly grown, diversely acclimated C4 leafy vegetable with climate resilience and salinity resistance. The application of salinity eustress in amaranth has a great scope to augment the nutritional and PA profiles and ARP. Therefore, the A. gangeticus genotype was evaluated in response to salt eustress for nutrients, PA profile, and ARP. Antioxidant potential and high-yielding genotype (LS1) were grown under four salt eustresses (control, 25 mM, 50 mM, 100 mM NaCl) in a randomized completely block design (RCBD) in four replicates. Salt stress remarkably augmented microelements, proximate, macro-elements, phytochemicals, PA profiles, and ARP of A. gangeticus leaves in this order: control < low sodium chloride stress (LSCS) < moderate sodium chloride stress (MSCS) < severe sodium chloride stress (SSCS). A large quantity of 16 PAs, including seven cinnamic acids (CAs) and nine benzoic acids (BAs) were detected in A. gangeticus genotypes. All the microelements, proximate, macro-elements, phytochemicals, PA profiles, and ARP of A. gangeticus under MSCS, and SSCS levels were much higher in comparison with the control. It can be utilized as preferential food for our daily diets as these antiradical compounds have strong antioxidants. Salt-treated A. gangeticus contributed to excellent quality in the end product in terms of microelements, proximate, macro-elements, phytochemicals, PA profiles, and ARP. A. gangeticus can be cultivated as an encouraging substitute crop in salt-affected areas of the world.

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“…Regarding vanillic acid, its presence has been reported in extracts with antimicrobial activity from other plants (Table S2), although Angelica sinensis (Oliv.) Diels is currently the largest commercial natural source [47]. The mechanism of action of its antimicrobial activity against clinically important bacteria, by inducing cell lysis, damaging the cell membrane, and causing leakage of intracellular components, has been studied by Li et al [48]; and it is considered a promising candidate antimicrobial agent not only to treat infections and as a surface disinfectant, but also as a food preservative in the food industry [49].…”

Section: Mode Of Actionmentioning

confidence: 99%

Valorization of Quercus suber L. Bark as a Source of Phytochemicals with Antimicrobial Activity against Apple Tree Diseases

Sánchez-Hernández

García

Casanova-Gascón

et al. 2022

Plants

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Cork, an anatomic adaptation of the bark of Quercus suber L. through its suberization process, finds its main application in the production of bottle stoppers. Its processing results in a large waste stream of cork fragments, granulates, and dust, which may be susceptible to valorization. The work presented here explored the use of its extracts to inhibit the growth of phytopathogenic microorganisms associated with apple tree diseases. The in vitro antimicrobial activity of cork aqueous ammonia extract was assayed against four fungi, viz. Monilinia fructigena and M. laxa (brown rot), Neofussicoccum parvum (dieback), and Phytophthora cactorum (collar and root rot), and two bacteria, viz. Erwinia amylovora and Pseudomonas syringae pv. syringae, either alone or in combination with chitosan oligomers (COS). Effective concentration values of EC90 in the 675–3450 μg·mL−1 range, depending on the fungal pathogen, were obtained in growth inhibition tests, which were substantially improved for the conjugate complexes (340–801 μg·mL−1) as a result of strong synergism with COS. Similar enhanced behavior was also observed in antibacterial activity assays, with MIC values of 375 and 750 μg·mL−1 for the conjugate complexes against P. syringae pv. syringae and E. amylovora, respectively. This in vitro inhibitory activity was substantially higher than those exhibited by azoxystrobin and fosetyl-Al, which were tested for comparison purposes, and stood out among those reported for other natural compounds in the literature. The observed antimicrobial activity may be mainly attributed to the presence of glycerin and vanillic acid, identified by gas chromatography–mass spectroscopy. In the first step towards in-field application, the COS–Q. suber bark extract conjugate complex was further tested ex situ against P. cactorum on artificially inoculated excised stems of the ‘Garnem’ almond rootstock, achieving high protection at a dose of 3750 μg·mL−1. These results suggest that cork industrial leftovers may, thus, be a promising source of bioactive compounds for integrated pest management.

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Discovering multifaceted role of vanillic acid beyond flavours: Nutraceutical and therapeutic potential

Cited by 89 publications

References 84 publications

Vanillic acid attenuates H2O2-induced injury in H9c2 cells by regulating mitophagy via the PINK1/Parkin/Mfn2 signaling pathway

Vanillic acid attenuates H2O2-induced injury in H9c2 cells by regulating mitophagy via the PINK1/Parkin/Mfn2 signaling pathway

Salt Eustress Induction in Red Amaranth (Amaranthus gangeticus) Augments Nutritional, Phenolic Acids and Antiradical Potential of Leaves

Valorization of Quercus suber L. Bark as a Source of Phytochemicals with Antimicrobial Activity against Apple Tree Diseases

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