Discovered on gastrointestinal stromal tumours 1 (DOG1) expression in non‐gastrointestinal stromal tumour (GIST) neoplasms

Hemminger, Jessica; Iwenofu, O. Hans

doi:10.1111/j.1365-2559.2011.04150.x

Cited by 64 publications

(66 citation statements)

References 36 publications

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“…Dog-1 is a calcium-activated chloride channel protein expressed strongly in the gastrointestinal interstitial Cajal cells and gastrointestinal stromal tumors, which arise from interstitial Cajal cells (Hemminger and Iwenofu, 2012;Miettinen, 2014). Nevertheless, the interstitial Cajal cells of the gut are very similar to telocytes ("Cajal-like cells").…”

Section: For This Reason Detection Of Telocytes Via Single Antibodiementioning

confidence: 99%

Telocytes (interstitial Cajal-like cells) in human Fallopian tubes

Urban¹,

Miko²,

Kajanova³

et al. 2016

BLL

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BACKGROUND: Telocytes represent a relatively newly discovered population of cells found within the various tissues and organs, including Fallopian tubes. It is presumed that telocytes could serve as a sensor of hormone levels or regulate activity of muscle peristaltic movement. METHODS: Tissue sections from anatomically different parts of Fallopian tubes of 48 women (age 48.8 ± 9.1) were stained for the expression of fi ve different antigens: c-kit (CD117), CD34, vimentin, podoplanin (D2-40) and Dog-1. RESULTS: Telocytes form a network associated with the smooth muscle cells. From the mentioned antibodies, only anti-c-kit (CD117) seems to be relatively selective specifi c to the telocytes, others react also with numerous other cells and tissue structures. Our results when using antibodies against podoplanin and Dog-1 are in dissonance with recent literature -with regards to our results, they are not suitable for detection of telocytes. CONCLUSION: Methods of immunohistochemistry are suitable for identifi cation of telocytes in Fallopian tubes. C-kit (CD117) antigens are useful for routine identifi cation of telocytes in histological sections. This antigen can be combined with CD34 or vimentin in cases of double staining immunohistochemistry (Tab. 1, Fig. 6, Ref. 44). Text in PDF www.elis.sk.

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Section: For This Reason Detection Of Telocytes Via Single Antibodiementioning

confidence: 99%

Telocytes (interstitial Cajal-like cells) in human Fallopian tubes

Urban¹,

Miko²,

Kajanova³

et al. 2016

BLL

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“…Karyotypic profiling of 11 AciCCs reveals that the only common change is trisomy 8 in 3 cases. 42 In addition to periodic acid-Schiff-positive cytoplasmic zymogen granules, recent studies 43,44 show AciCCs are positive for deletion of guanine-rich DNA 1 (DOG-1), SRY-related HMG-box 10 (Sox10), amylase, carbonic anhydrase VI, and salivary proline-rich proteins; and negative for maspin and myoepithelial markers. The tumor may have focal neuroendocrine staining pattern.…”

Section: Acinic Cell Carcinomamentioning

confidence: 99%

Fine-Needle Aspiration Biopsy of Salivary Gland Lesions

Wang

Fundakowski²,

Khurana³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Fine-needle aspiration (FNA) is a well-established diagnostic approach for salivary gland lesions; however, lack of a standard system of terminology for classification of salivary gland neoplasms collected by FNA and the relatively high frequency of uncertainty of diagnosis are likely partly responsible for current confusion in the interpretation of these FNA samples.Objective.-To propose a novel classification system for reporting salivary gland FNA samples and summarize recent progress in application of molecular and immunohistochemical markers in selected salivary gland neoplasms.Data Sources.-Literature review and authors' personal practice experience.Conclusions.-The new classification system provides a more succinct, standardized interpretation of results and will ultimately assist in communication between clinicians, clinical decision making, and preoperative patient counseling. Impressive advances have been made in recent years in the understanding of molecular pathogenesis of salivary gland tumors. With the newly acquired diagnostic tools, significant improvement in diagnostic accuracy of salivary gland FNA can certainly be expected.(Arch Pathol Lab Med. 2015;139:1491-1497; doi: 10.5858/arpa.2015-0222-RA) M asses or cystic lesions of salivary glands have a wide range of differential diagnoses, from inflammatory response to neoplasm and to less common causes of infection.1 The World Health Organization has described 45 morphologic types of primary salivary gland tumors. Fine-needle aspiration (FNA) is a well-established diagnostic approach for salivary gland lesions. Zbaren et al 3 have noted accuracy, sensitivity, and specificity rates for salivary gland FNA of 79% (87 of 110), 74% (50 of 68), and 88% (37 of 42), respectively. Fine-needle aspiration has a higher sensitivity/specificity for benign masses than for malignancy. 4 Carrillo et al 5 also noted that FNA has the potential to change the clinical approach for up to one-third of patients. Salivary lesions remain, however, one of the most challenging entities in cytopathology, mainly because of the diversity of histologic subtypes and the often overlapping morphologic features of the lesions.

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“…'nın [9] yaptığı çalışmada ise 117 GİST dışı yumuşak doku tümörü olgusunun yalnızca 3 tanesinde (Desmoplastik Melanoma, malign periferik sinir kılıfı tümörü ve Schwannoma olguları) DOG1 pozitifliği saptanmıştır. Sinovyal sarkom, düşük dereceli fibromiksoid sarkom, Leiomyosarkom, Perinöroma, Nörofibroma, Anjiosarkoma olgularında DOG1 negatif bulunmuştur [8]. Bir başka çalışmada, 23 farklı neoplazi grubunun temsil edildiği 125 vakalık seride yalnızca üç yumuşak doku tümörü vakasında (Ewing sarkomu, Glomus tümörü ve Sinovyal sarkom) DOG1 pozitifliği saptanmıştır.…”

Section: Discussionunclassified

“…Sonuç olarak farklı çalışmalarda GİST ayırıcı tanısında yer alan Sinovial sarkom, Leiomyosarkom, Fibrosarkom, Ewing sarkomu, malign periferik sinir kılıfı tümörü, Glomus tümörü, Peritoneal leiomyomatöz lezyonlar, Anjiosarkom, Schwannom ve Desmoplastik melanomlarda %0,3-2,5 oranında fokal ve soluk DOG1 ekspresyonundan bahsedilmektedir [5,6,[8][9][10]. Bizim çalışmamızda, daha önce yapılan çalışmalara benzer şekilde Nörofibroma, Desmoid tümör ve Dermatofibrosarkoma protuberans olgularında DOG1 ekspresyonu saptanmamış, DOG1'in bu tümörlerde tanısal değerinin olmadığı anlaşılmıştır.…”

Section: Discussionunclassified

Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili

Ersöz¹,

Kankaya²,

Kiremitci³

et al. 2014

Cumhuriyet Med J

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Amaç. Gastrointestinal stromal tümörlerde (GİST) spesifik olarak ekspresyon gösteren ve kalsiyum bağımlı klorid kanalı olarak bilinen DOG1, gastrointestinal stromal tümörlerin diğer sarkomlardan ayrımında kullanılan tanısal bir belirteçtir. Çeşitli araştırmalarda Gastrointestinal stromal tümor dışı mezenşimal tümörlerde değişen oranda DOG1 ekspresyonu bildirilmiştir. AbstractAim. DOG1 is a calcium-dependent chlorid channel, that shows specific expression in Gastrointestinal stromal tumors (GIST) can be used in differential diagnosis of these tumors with other soft tissue sarcomas. In several studies, DOG1 expression has been reported in varying proportions in Non-GIST mesenchymal tumors. In this study, we aimed to find the DOG1 expression profile in Nodular fasciit, Neurofibroma, Desmoid tumors and Dermatofibrosarcoma protuberans. Method. Nodular fasciit (n=8), Neurofibroma (n=8), Desmoid tumors (n=8) and Dermatofibrosarcoma protuberans (n=8) cases, diagnosed in Ankara University, Faculty of Medicine, Department of Pathology between 2005-2012, were included in this study. Results. Focal and pale DOG1 reactivity was seen only in one case of Nodular fasciit (1/8) whereas the remainig cases were negative with DOG1. Conclusion. DOG1 has no diagnostic value in benign and locally aggressive fibroblastic/myofibroblastic neoplasms and neurofibromas.

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Discovered on gastrointestinal stromal tumours 1 (DOG1) expression in non‐gastrointestinal stromal tumour (GIST) neoplasms

Abstract: Our study supports that DOG-1 is a highly sensitive and specific marker for GISTs and also highlights hitherto unrecognized and unusual patterns of expression in non-mesenchymal neoplasms.

Cited by 64 publications

References 36 publications

Telocytes (interstitial Cajal-like cells) in human Fallopian tubes

Telocytes (interstitial Cajal-like cells) in human Fallopian tubes

Fine-Needle Aspiration Biopsy of Salivary Gland Lesions

Fibroblastik/myofibroblastik benign ve lokal agresif neoplaziler ve nörofibromalarda DOG1 ekspresyon profili

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