Disappearance of contralateral dominant neural activity of auditory cortex after single-sided deafness in adult rats

Lee, Min Young; Kim, Doo Hee; Park, Su Kyoung; Jun, Sang Beom; Lee, Yena; Choi, Jun Jae; Yoo, Hyun Ji; Raphael, Yehoash; Oh, Seung Ha

doi:10.1016/j.neulet.2017.08.001

Cited by 12 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recovery of the decreased Mn 2+ SI on the ipsilateral side of the CN and contralateral side of the SOC, LL, and IC in the SSD-8-week group compared to the SSD-4-week group suggests that neural activities resumed in the deafferented auditory neural pathways. This finding accords with that of our previous study, which showed recovery of decreased cortical activities during 4–8 weeks after SSD [5]. Continuous auditory stimulation from the normal ear may influence the neural activity of deafferented nuclei along the brainstem because of the binaural interaction components of the subcortical auditory nervous system [27].…”

Section: Discussionsupporting

confidence: 92%

“…Then, the opening in the cochlea was closed with glue, and a subcutaneous 4.0 Vicryl suture was added. Hearing levels were confirmed before MEMRI acquisitions in all mice groups using the auditory brainstem response (ABR) (SmartEP, Intelligent Hearing Systems, Miami, FL, USA) as described previously [5]. The ABR results are presented in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…The differences in the experience of hearing between prelingual and postlingual SSD patients might result in different changes to the brain auditory pathways following single-sided hearing deprivation. We have demonstrated the disappearance of contralateral dominance in the auditory cortex after SSD in adult rats [5]. However, it is still elusive whether these changes in auditory cortical activities occur independently or accompany subcortical auditory neural changes.…”

Section: Introductionmentioning

confidence: 99%

“…Several prior studies used conductive hearing loss models, but these models could be contaminated with ipsilateral cochlear stimulation by crossed sounds [7, 8]. After SSD, the contralateral dominance of the auditory midbrain and cortex response disappears [5, 11, 12]. However, a few previous studies showed changes in subcortical auditory neural activities after cochlear ablation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study

Kim

Heo

Kim

et al. 2018

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Single-sided deafness (SSD) induces cortical neural plastic changes according to duration of deafness. However, it is still unclear how the auditory cortical changes accompany the subcortical neural changes. The present study aimed to find the neural plastic changes in the cortical and subcortical auditory system following adult-onset single-sided deafness (SSD) using Mn-enhanced magnetic resonance imaging (MEMRI). B57BL/6 mice (postnatal 8-week-old) were divided into three groups: the SSD-4-week group (postnatal 12-week-old, n = 11), the SSD-8-week group (postnatal 16-week-old, n = 11), and a normal-hearing control group (postnatal 8-week-old, n = 9). The left cochlea was ablated in the SSD groups. White Gaussian noise was delivered for 24 h before MEMRI acquisition. T1-weighted MRI data were analyzed from the cochlear nucleus (CN), superior olivary complex (SOC), lateral lemniscus (LL), inferior colliculus (IC), medial geniculate body (MG), and auditory cortex (AC). The differences in relative Mn2+-enhanced signal intensities (Mn2+SI) and laterality were analyzed between the groups. Four weeks after the SSD procedure, the ipsilateral side of the SSD showed significantly lower Mn2+SI in the CN than the control group. On the other hand, the contralateral side of the SSD demonstrated significantly lower Mn2+SI in the SOC, LL, and IC. These decreased Mn2+SI values were partially recovered at 8 weeks after the SSD procedure. The interaural Mn2+SI differences representing the interaural dominance were highest in CN and then became less prominently higher in the auditory neural system. The SSD-8-week group still showed interaural differences in the CN, LL, and IC. In contrast, the MG and AC did not show any significant intergroup or interaural differences in Mn2+SI. In conclusion, subcortical auditory neural activities were decreased after SSD, and the interaural differences were diluted in the higher auditory nervous system. These findings were attenuated with time. Subcortical auditory neural changes after SSD may contribute to the change in tinnitus severity and the outcomes of cochlear implantation in SSD patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study

Kim

Heo

Kim

et al. 2018

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ear plugging in early stages of development promote changes which are more difficult to reverse 54 , suggesting that early and late-onset hearing loss in one ear are mediated differently. Whereas the immature auditory pathway may experience architectural change, including neuronal and glial loss in brainstem structures connected to the deaf ear 55,56 , the mature pathway responds to the loss of input from one ear through changes of inhibitory/excitatory transmission [57][58][59][60] . In the adolescents, SSD onset may be occurring during a potentially important development transition, reflected by maturation of cortical responses by ~ 12 years of age 24,47 .…”

Section: Aural Preference: Auditory Cortex Ipsilateral To Nh Earmentioning

confidence: 99%

Consistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children

Lee

Smieja

Polonenko

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Potentially neuroprotective effects of CI use were studied in 22 children with single sided deafness (SSD). Auditory-evoked EEG confirmed strengthened representation of the intact ear in the ipsilateral auditory cortex at initial CI activation in children with early-onset SSD (n = 15) and late-onset SSD occurring suddenly in later childhood/adolescence (n = 7). In early-onset SSD, representation of the hearing ear decreased with chronic CI experience and expected lateralization to the contralateral auditory cortex from the CI increased with longer daily CI use. In late-onset SSD, abnormally high activity from the intact ear in the ipsilateral cortex reduced, but responses from the deaf ear weakened despite CI use. Results suggest that: (1) cortical reorganization driven by unilateral hearing can occur throughout childhood; (2) chronic and consistent CI use can partially reverse these effects; and (3) CI use may not protect children with late-onset SSD from ongoing deterioration of pathways from the deaf ear.

show abstract

Sound-localisation performance in patients with congenital unilateral microtia and atresia fitted with an active middle ear implant

Zhao

Liu

Yang

et al. 2020

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Disappearance of contralateral dominant neural activity of auditory cortex after single-sided deafness in adult rats

Cited by 12 publications

References 33 publications

Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study

Neural Plastic Changes in the Subcortical Auditory Neural Pathway after Single-Sided Deafness in Adult Mice: A MEMRI Study

Consistent and chronic cochlear implant use partially reverses cortical effects of single sided deafness in children

Sound-localisation performance in patients with congenital unilateral microtia and atresia fitted with an active middle ear implant

Contact Info

Product

Resources

About