Disappearance of a Serum Paraprotein After Parathyroidectomy

Clubb, John S.; Posen, Solomon; Neale, Frank C.

doi:10.1001/archinte.1964.03860110086006

Cited by 40 publications

(13 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…By itself, however, the monoclonal-like staining of H and SR cells does not disprove the possibility that the Clg was phagocytosed by the H and SR cells, since it is well known that in long-standing infections and immune reactions the antibodies produced may show restricted heterogeneity (Clubb et al, 1964;Munthe andNatvig, 1970Vandvik, 1972 ;Kinsella et al, 1969Kinsella et al, , 1970. When these cells contain rheumatoid factor, the staining pattern appears to be globular.…”

Section: Resultsmentioning

confidence: 98%

“…By itself, however, the monoclonal-like staining of H and SR cells does not disprove the possibility that the Clg was phagocytosed by the H and SR cells, since it is well known that in long-standing infections and immune reactions the antibodies produced may show restricted heterogeneity (Clubb et al, 1964;Munthe andNatvig, 1970Vandvik, 1972). It is conceivable that plasma cells present in the lymphogranulomatous tissue produce Ig restricted to one heavy-chain class and, less often, one light-chain type; this Ig of restricted heterogeneity might be phagocytosed by H and SR cells located near the plasma cells, which would lead to restricted CIg staining of the H and SR cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α₁‐antichymotrypsin and lysozyme

Papadimitriou

Stein

Lennert

1978

Intl Journal of Cancer

View full text Add to dashboard Cite

The immunoperoxidase-bridge technique was applied to 103 lymph-node and spleen biopsies from Hodgkin's disease t o detect intracytoplasmic immunoglobulin (Clg). The plasma cells that stained positively for gamma, mu, alpha, or delta chains varied greatly in number from case to case, depending somewhat on the histologic type of the disease. Hodgkin (H) and Sternberg-Reed (SR) cells that stained for gamma chains were the most frequent, followed by those positive for delta chains. H and SR cells positive for mu or alpha chains were usually sparse. In 11 cases gamma and delta chains were present simultaneously i n single cells. N o other combination of heavy-chain classes could be found in H and SR cells. In five cases of the lymphocytic-depletion type, the Clg was restricted to one heavy-chain class and one light-chain type. Gamma-chain subtypes were determined in a total of 24 cases. In the cases with one light-chain type and in four other cases, only gamma, chains were present in the H and SR cells. In many cases the proportion of H and SR cells positive for each gamma-chain subclass was not the same as that of the surrounding plasma cells. Variable numbers of H and SR cells showed unequivocal positivity for albumin in 12, alpha,-antichymotrypsin in 12, and lysozyme in one out of the 44 cases tested. In 21 out of these 44 cases only Clg could be detected. The findings presented here are discussed i n relation t o the possible monocytoid/macrophage or lymphoid B-cell nature of H and SR cells. Our data provide evidence for both a lymphatic and a macrophage origin of H and SR cells. It i s not possible to reconcile these data on the basis of present knowledge.

show abstract

Section: Resultsmentioning

confidence: 98%

“…By itself, however, the monoclonal-like staining of H and SR cells does not disprove the possibility that the Clg was phagocytosed by the H and SR cells, since it is well known that in long-standing infections and immune reactions the antibodies produced may show restricted heterogeneity (Clubb et al, 1964;Munthe andNatvig, 1970Vandvik, 1972). It is conceivable that plasma cells present in the lymphogranulomatous tissue produce Ig restricted to one heavy-chain class and, less often, one light-chain type; this Ig of restricted heterogeneity might be phagocytosed by H and SR cells located near the plasma cells, which would lead to restricted CIg staining of the H and SR cells.…”

Section: Discussionmentioning

confidence: 99%

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α₁‐antichymotrypsin and lysozyme

Papadimitriou

Stein

Lennert

1978

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Clubb et al [38] described first-case linking PHPT and paraproteinemia in 1964. Drezner and Lebovitz were the first who described a case of concomitant MM and PHPT in 1979 [30].…”

Section: Discussionmentioning

confidence: 99%

A Case of Multiple Myeloma Coexisting with Primary Hyperparathyroidism and Review of the Literature

Hussain

Khan

Natarajan

et al. 2013

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

Hypercalcemia is a common medical problem with an estimated prevalence of 15% among hospitalized patients. Multiple myeloma (MM) and primary hyperparathyroidism (PHPT) are among the most common causes of hypercalcemia but coexistence of both pathologic processes in a patient is an extremely rare phenomenon. In this paper we have discussed a patient presenting with this rare phenomenon. We have also provided a comprehensive review of the scientific literature published on codiagnosis of MM and PHPT.

show abstract

“…Clubb et al (1964) reported a case in which a serum 'paraprotein' fraction disappeared after the removal of a hyperactive parathyroid adenoma, though they reported later that the paraprotein reappeared in the serum two and a half years after the operation. Furthermore, several cases of monoclonal IgG gammopathy associated with hyperparathyroidism have been reported (Dexter et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

Hypercalcaemia due to hyperparathyroidism in a patient with chronic renal failure and renal carcinoma.

Szwed¹,

Gott²,

Lempke³

et al. 1979

J Clin Pathol

View full text Add to dashboard Cite

SUMMARY A 65-year-old woman with a history of a left heminephrectomy for renal carcinoma developed hypercalcaemia 11 years after the operation. The same kidney was found to contain a recurrent renal carcinoma. After the radical nephrectomy of the left kidney, hypercalcaemia remitted but reappeared 11 months later. The right kidney was small but functioned at a level of creatinine clearance of 10-15 ml/min. Metastatic work-up was negative, and secondary causes of hypercalcaemia were excluded. A neck exploration revealed a parathyroid adenoma. With parathyroid resection the serum calcium declined to normal, and the risk of hypercalcaemic nephropathy in the remaining kidney was precluded.Hypercalcaemia is a common manifestation of malignancy of numerous organs, including the kidney (Albright and Reifenstein, 1948;Connor et al., 1956;Plimpton and Gellhorn, 1956;Gold and Shnider, 1959;Lucas, 1960; David et al., 1963; Noenickx et al., 1962;Moses and Spencer, 1963;Samuelsson and Werner, 1963;Goldberg et al., 1964). Primary hyperparathyroidism is a relatively common disorder, usually benign, with a frequency of 1 case per 1000 persons per year. The most common manifestation of this disorder is hypercalcaemia (Thorn et al., 1977). The association of renal carcinoma and hyperparathyroidism in the same patient is uncommon and has rarely been diagnosed before the death of the patient (Bernstein et al., 1965;Salama et al., 1971;Nemoto et al., 1977).This report describes a patient with chronic renal failure, who had had a total left nephrectomy for a recurrent renal carcinoma accompanied by hypercalcaemia and, 11 months later, was found to have recurrent hypercalcaemia. The recurrent hypercalcaemia was not due to recurrent renal carcinoma but rather to a parathyroid adenoma. After removal of a parathyroid adenoma the hypercalcaemia remitted.Received for publication 5 September 1978 Case reportThe patient is a woman who was found to have a carcinoma of the left kidney during evaluation of vaginal prolapse in 1965 at age 54. The physical examination was normal except for obvious vaginal prolapse. The full blood count, urine analysis, serum electrolytes, serum calcium and phosphate, and creatinine clearance were normal. She underwent segmental resection of the left kidney (Fig. 1). On microscopic examination the tumour was a renal carcinoma. There were no metastases nor was there evidence of local invasion. At the time of the operation the patient was described as being quite 'irritable' by several physicians. She was discharged from hospital and followed with yearly intravenous pyelograms.In July 1976, 11 years after the first operation, she was found to have progressive dilatation and clubbing of upper pole calyces, and an angiogram (Fig. 2) showed a 7 x 4 x 5 cm tumour mass involving one-half to two-thirds of the upper pole of the left kidney. The right kidney appeared to be small but without gross tumour involvement. Investigation revealed that the haemoglobin was 12-0 g/dl, WBC 7-8 x 109/l with a normal differential. T...

show abstract

Disappearance of a Serum Paraprotein After Parathyroidectomy

Cited by 40 publications

References 6 publications

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α₁‐antichymotrypsin and lysozyme

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α₁‐antichymotrypsin and lysozyme

A Case of Multiple Myeloma Coexisting with Primary Hyperparathyroidism and Review of the Literature

Hypercalcaemia due to hyperparathyroidism in a patient with chronic renal failure and renal carcinoma.

Contact Info

Product

Resources

About

Disappearance of a Serum Paraprotein After Parathyroidectomy

Cited by 40 publications

References 6 publications

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α1‐antichymotrypsin and lysozyme

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α1‐antichymotrypsin and lysozyme

A Case of Multiple Myeloma Coexisting with Primary Hyperparathyroidism and Review of the Literature

Hypercalcaemia due to hyperparathyroidism in a patient with chronic renal failure and renal carcinoma.

Contact Info

Product

Resources

About

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α₁‐antichymotrypsin and lysozyme

The complexity of immunohistochemical staining pattern of hodgkin and sternberg‐reed cells—demonstration of immunoglobulin, albumin, α₁‐antichymotrypsin and lysozyme