A Case of Multiple Myeloma Coexisting with Primary Hyperparathyroidism and Review of the Literature

Hussain, Nasir; Khan, Moona; Natarajan, Aparna; Mohammedabdul, Mubeenkhan; Mustafa, Usman; Yedulla, Kalpana; Mirrakhimov, Aibek E.

doi:10.1155/2013/420565

Cited by 12 publications

(18 citation statements)

References 32 publications

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“…On the other hand, a prospective study done in 2002 showed the prevalence of monoclonal gammopathies is higher in patients with primary hyperparathyroidism when compared to the general population. That finding supports the hypothesis of an association between monoclonal gammopathy of undetermined significance or multiple myeloma with primary hyperparathyroidism [ 1 , 8 ].…”

Section: Discussionsupporting

confidence: 88%

“…Primary hyperparathyroidism can cause hypercalcemia through increasing calcium reabsorption by distal tubules in the kidneys, increasing bone resorption and increasing activation of vitamin D, which will increase gastrointestinal absorption of calcium [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several causes of hypercalcemia have been described. Primary hyperparathyroidism and malignancy have been responsible for more than 80% percent of cases [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Coexistence of multiple myeloma and primary hyperparathyroidism as a cause of hypercalcemia is extremely rare with fewer than 30 cases reported in the literature [ 1 ]. Most of the cases were diagnosed after failure to correct calcium level targeting the initial diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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A case of hypercalcemia with double pathology

Abdalla

Bachuwa

Hadidi

2017

Journal of Community Hospital Internal Medicine Perspectives

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Hypercalcemia has many causes including primary hyperparathyroidism, malignancy, and other rare etiologies. In most of the cases, hypercalcemia is secondary to one etiology. In this case, we are reporting hypercalcemia with two causes. The initial workup showed primary hyperparathyroidism due to parathyroid adenoma. But because all features were not fully explained by primary hyperparathyroidism, further work-up revealed multiple myeloma. This case represents coexistence of two different diseases, which was rarely reported in the literature previously. Usually, the co-diagnosis was made subsequently after failure to correct hypercalcemia. In our case, both diagnoses were established at the same time of the patient’s presentation as of high suspicion. Establishing the diagnosis early will aid in the initiation of treatment in a timely fashion.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

“…Several causes of hypercalcemia have been described. Primary hyperparathyroidism and malignancy have been responsible for more than 80% percent of cases [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case of hypercalcemia with double pathology

Abdalla

Bachuwa

Hadidi

2017

Journal of Community Hospital Internal Medicine Perspectives

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“…rülen ve sıklıkla atlanabilecek bir durumdur. Literatürde şu ana kadar yaklaşık 30 olguda PHP ve MM birlikteliği bildirilmiştir (2,3). Bu olguların bir kısmında öncelikle MM'ye bağlı olduğu düşünülen hiperkalsemi tedavi edilmeye çalışılmış, ancak hiperkalseminin kontrol altına alınamaması üzerine beraberinde PHP tanısının varlığı gösterilebilmiştir.…”

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Should We Consider Primary Hyperparatyroidism in Multiple Myeloma Cases with Hypercalcemia

Şahin¹,

Gelgeç²,

Özçelik³

et al. 2017

LLM Dergi

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Hiperkalsemi, hastaneye yatan hastalarda sık rastlanan bir klinik problemdir. Hiperkalseminin en yaygın sebepleri arasında yer alan primer hiperparatiroidi ve malign hematolojik hastalıklardan multipl miyelomun birlikte görülmesi ise oldukça nadir bir durumdur. Literatürde şu ana kadar toplam 30 olgu primer hiperparatiroidi ve multipl miyelom birlikteliği şeklinde bildirilmiştir. Biz de burada, bu nadir duruma ithafen, kliniğimizde takipli üç olgu ile primer hiperparatirodi ve multipl miyelom birlikteliği deneyimimizi paylaşmayı hedefledik.

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Simultaneous primary hyperparathyroidism and multiple myeloma in a dog with hypercalcaemia

Sztukowski

Gin

Neel

et al. 2021

Vet Record Case Reports

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A 14-year-old male castrated Pomeranian was found to be hypercalcaemic and hyperglobulinaemic during investigation of anorexia and haematochezia. Ionised hypercalcaemia, increased serum parathyroid hormone concentration, normophosphatemia and a parathyroid nodule found on cervical ultrasound examination were diagnostic for primary hyperparathyroidism (PHPT). Thoracic radiographs revealed ovoid lytic lesions in multiple bones. To investigate the hyperglobulinaemia, serum electrophoresis and immunoglobulin (Ig) quantification were performed, revealing an IgA biclonal gammopathy. Bone marrow cytopathology confirmed multiple myeloma (MM). Following bilateral parathyroidectomy, the dog's hypercalcaemia resolved, and pulse-dose chemotherapy with prednisone and melphalan was initiated to treat MM. To the authors' knowledge, this is a unique case report of simultaneous PHPT and MM in the veterinary literature, diseases that are rarely reported concurrently in humans. This case highlights the need to thoroughly investigate multiple problems when they are not explained by a single diagnosis.

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A Case of Multiple Myeloma Coexisting with Primary Hyperparathyroidism and Review of the Literature

Cited by 12 publications

References 32 publications

A case of hypercalcemia with double pathology

A case of hypercalcemia with double pathology

Should We Consider Primary Hyperparatyroidism in Multiple Myeloma Cases with Hypercalcemia

Simultaneous primary hyperparathyroidism and multiple myeloma in a dog with hypercalcaemia

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