Disabling gout

Ak, Tausche; Panzner, Ines; Aust, D; Wunderlich, Carsten

doi:10.1016/s0140-6736(10)60135-3

Cited by 10 publications

(6 citation statements)

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“…Acute gout manifests when monosodium urate (MSU) crystallizes and deposits in joints, bursae or tendon sheaths, and provokes an inflammatory response that causes a typical gout flare. This flare is characterized by an acute onset (maximum within 24 hours) of a heavily inflamed and extremely painful mono- or oligoarthritis which often results in short-term sick leave [6]. Serum urate (sUA) concentration above the limit of solubility (>6.8 mg/dL/400 μmol/L) leads to crystal deposition which is a necessary precursor for this disease, though many with hyperuricemia will never develop gout [7,8].…”

Section: Introductionmentioning

confidence: 99%

Tophi and frequent gout flares are associated with impairments to quality of life, productivity, and increased healthcare resource use: Results from a cross-sectional survey

Khanna

Nuki

Bardin

et al. 2012

Health Qual Life Outcomes

163

112

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BackgroundThe prevalence of gout is increasing, and most research on the associated burden has focused on serum urate (sUA) levels. The present study quantifies the impact of the presence of tophi and frequency of acute gout attacks on health-related quality of life (HRQOL), productivity, and healthcare resource utilization.MethodsPatients with self-reported gout (n = 620; 338 in US and 282 across France, Germany, and UK) were contacted based on inclusion in the 2010 US and EU National Health and Wellness Surveys (Kantar Health) and the Lightspeed Research ailment panel. Respondents were categorized into mutually-exclusive groups based on number of gout flares experienced in the past 12 months (0/don’t recall, 1–2, 3, 4–5, 6+), current presence of tophi (none, 1+, or not sure), and sUA level awareness (yes, no). HRQOL (SF-12v2), healthcare provider visits in the last 6 months, and work productivity and activity impairment (WPAI) were compared across groups.ResultsMost patients were males, mean age of 61 years, who reported experiencing at least one acute gout flare in the past 12 months, and 12.3% (n = 76) reported presence of tophi. Among the 27.7% (n = 172) of patients who were aware of their sUA levels, higher sUA was associated with more flares and tophi. Decreased HRQOL was associated with more frequent flares and presence of tophi. In multivariable models predicting outcomes based on presence of tophi and number of flares, both flares (≥4) and tophi (≥1) were associated with HRQOL decrements on physical and mental component summary scores and health utilities (all p < 0.05), after adjustment for age, gender, and time since diagnosis. Flares were also associated with greater activity impairment.ConclusionsImpairments associated with gout flares and presence of tophi, across patients in the US and EU, underscore the importance of effective management of this potentially curable condition.

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Section: Introductionmentioning

confidence: 99%

Tophi and frequent gout flares are associated with impairments to quality of life, productivity, and increased healthcare resource use: Results from a cross-sectional survey

Khanna

Nuki

Bardin

et al. 2012

Health Qual Life Outcomes

163

112

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“…Due to the severity of acute gout, people are often unable to work, leading to short-term sick leave (13).…”

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confidence: 99%

Gout Severity, Socioeconomic Status, and Work Absence: A Cross‐Sectional Study in Primary Care

Bowen-Davies

Müller

Mallen

et al. 2018

Arthritis Care & Research

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“…In fact, it is the most common form of arthritis in men 4 and can still be devastating. 5 The clinically most relevant crystals inducing arthritis are monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals. Their identification via regular light and polarization microscopy is the only accepted method of establishing an acute arthritis as due to gout or CPP deposition disease.…”

mentioning

confidence: 99%

A 3-Day Delay in Synovial Fluid Crystal Identification Did Not Hinder the Reliable Detection of Monosodium Urate and Calcium Pyrophosphate Crystals

Tausche¹,

Gehrisch²,

Panzner³

et al. 2013

Journal of Clinical Rheumatology

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Disabling gout

Cited by 10 publications

References 0 publications

Tophi and frequent gout flares are associated with impairments to quality of life, productivity, and increased healthcare resource use: Results from a cross-sectional survey

Tophi and frequent gout flares are associated with impairments to quality of life, productivity, and increased healthcare resource use: Results from a cross-sectional survey

Gout Severity, Socioeconomic Status, and Work Absence: A Cross‐Sectional Study in Primary Care

A 3-Day Delay in Synovial Fluid Crystal Identification Did Not Hinder the Reliable Detection of Monosodium Urate and Calcium Pyrophosphate Crystals

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