Disability is already pronounced in young people with early stages of affective disorders: Data from an early intervention service

Hamilton, Blake; Naismith, Sharon L.; Scott, Elizabeth; Purcell, S; Hickie, Ian B.

doi:10.1016/j.jad.2010.10.052

Cited by 59 publications

(56 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Probably severe somatic comorbidity is present also, but this remains to be shown. These are in accord with research data which support the validity of the early vs. late stages in terms of differences in functioning and disability Rosa et al 2012Rosa et al , 2014Scott et al 2013 ;Hamilton et al 2011 ).…”

Section: Clinical Determinants Of Bd Stagingsupporting

confidence: 89%

Staging of Bipolar Disorder

Fountoulakis

2014

Bipolar Disorder

View full text Add to dashboard Cite

Section: Clinical Determinants Of Bd Stagingsupporting

confidence: 89%

Staging of Bipolar Disorder

Fountoulakis

2014

Bipolar Disorder

View full text Add to dashboard Cite

“…All patients who entered the services were assessed and managed by medically and/or psychologically-trained health professionals [28]. In this sub-study, an independent psychiatrist or trained research psychologist also conducted a standardized clinical interview, focusing on assessment of the detailed criteria developed for formal application of our clinical staging framework [13,28].…”

Section: Methodsmentioning

confidence: 99%

Frontal lobe changes occur early in the course of affective disorders in young people

et al. 2012

View full text Add to dashboard Cite

BackgroundMore severe and persistent forms of affective disorders are accompanied by grey matter loss in key frontal and temporal structures. It is unclear whether such changes precede the onset of illness, occur early in the course or develop gradually with persistence or recurrence of illness. A total of 47 young people presenting with admixtures of depressive and psychotic symptoms were recruited from specialist early intervention services along with 33 age matched healthy control subjects. All participants underwent magnetic resonance imaging and patients were rated clinically as to current stage of illness. Twenty-three patients were identified as being at an early 'attenuated syndrome' stage, while the remaining were rated as having already reached the 'discrete disorder' or 'persistent or recurrent illness' stage. Contrasts were carried out between controls subjects and patients cohorts with attenuated syndromes and discrete disorders, separately.ResultsThe patients that were identified as having a discrete or persisting disorder demonstrated decreased grey matter volumes within distributed frontal brain regions when contrasted to both the control subjects as well as those patients in the attenuated syndrome stage. Overall, patients who were diagnosed as more advanced in terms of the clinical stage of their illness, exhibited the greatest grey matter volume loss of all groups.ConclusionsThis study suggests that, in terms of frontal grey matter changes, a major transition point may occur in the course of affective illness between early attenuated syndromes and later discrete illness stages.

show abstract

“…Rates of vocational disengagement (31%) in this sample were double the rate of national youth unemployment (15%) in 20-24 year olds (Carvalho, 2015), although the rates of disengagement from work and study were similar to other young help-seeking samples (24-29%) (Hamilton et al, 2011;Rickwood et al, 2014). Impaired decision making, impulsivity and strategy formation (SWM task) were all associated with either quality or level of vocational engagement.…”

Section: Vocational Functioning Neurocognitive Outcomes and Associatmentioning

confidence: 56%

“…Young adults presenting to early intervention services are predominantly experiencing affective and anxiety symptoms (37-53%), high or very high levels of distress (69%) and substantial levels of disability, with 55% of 21-25 year old males and 62% of similarly aged females reporting at least one day away from their occupational role due to mental ill health (Hamilton et al, 2011;Rickwood et al, 2014). People with severe mental illnesses such as psychosis, which emerge in adolescence and early adulthood, have been reported to have particularly high rates of unemployment, exceeding 40% .…”

Section: Introductionmentioning

confidence: 99%

Prediction of vocational participation and global role functioning in help-seeking young adults, from neurocognitive, demographic and clinical variables

Cairns

Kavanagh

Dark

et al. 2017

Journal of Affective Disorders

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Disability is already pronounced in young people with early stages of affective disorders: Data from an early intervention service

Cited by 59 publications

References 31 publications

Staging of Bipolar Disorder

Staging of Bipolar Disorder

Frontal lobe changes occur early in the course of affective disorders in young people

Prediction of vocational participation and global role functioning in help-seeking young adults, from neurocognitive, demographic and clinical variables

Contact Info

Product

Resources

About