Staging of Bipolar Disorder

Fountoulakis, Kostas N.

doi:10.1007/978-3-642-37216-2_15

Cited by 2 publications

(3 citation statements)

References 124 publications

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“…Staging is the term that defines this procedure (Fountoulakis, 2015k). The field in medicine where staging is most successful and enjoys great importance is that of clinical oncology.…”

Section: Introductionmentioning

confidence: 99%

“…After the introduction of operationalized diagnostic criteria for all contemporary classification systems, the need to define and rate seriousness, progression, changes in physiology, and damage made and the extent and the specific characteristics of the disease emerged. Staging is the term that defines this procedure ( Fountoulakis, 2015k ). The field in medicine where staging is most successful and enjoys great importance is that of clinical oncology.…”

Section: Introductionmentioning

confidence: 99%

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The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Fountoulakis

Young

Yatham

et al. 2016

IJNPPY

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Background:This paper includes a short description of the important clinical aspects of Bipolar Disorder with emphasis on issues that are important for the therapeutic considerations, including mixed and psychotic features, predominant polarity, and rapid cycling as well as comorbidity.Methods:The workgroup performed a review and critical analysis of the literature concerning grading methods and methods for the development of guidelines.Results:The workgroup arrived at a consensus to base the development of the guideline on randomized controlled trials and related meta-analyses alone in order to follow a strict evidence-based approach. A critical analysis of the existing methods for the grading of treatment options was followed by the development of a new grading method to arrive at efficacy and recommendation levels after the analysis of 32 distinct scenarios of available data for a given treatment option.Conclusion:The current paper reports details on the design, method, and process for the development of CINP guidelines for the treatment of Bipolar Disorder. The rationale and the method with which all data and opinions are combined in order to produce an evidence-based operationalized but also user-friendly guideline and a specific algorithm are described in detail in this paper.

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“…Staging is the term that defines this procedure (Fountoulakis, 2015k). The field in medicine where staging is most successful and enjoys great importance is that of clinical oncology.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Fountoulakis

Young

Yatham

et al. 2016

IJNPPY

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“…The dominant BD‐specific staging models were developed by Berk et al 4,5 and Kapczinski et al 6 Both models describe the features and correlates of BD as it progresses, broadly agreeing on an at‐risk stage, which is followed by subthreshold symptoms, then progression to threshold illness, then recurrence and finally chronic, unremitting illness, with loss of functioning and autonomy 7,8 . A summary of these models and their proposed features can be found in the Supporting Information.…”

Section: Introductionmentioning

confidence: 99%

Conceptualizing the later stage of bipolar disorder: Descriptive analyses from the ORBIT trial

2020

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Objectives This study aimed to investigate the features of later stage bipolar disorder (BD) and specifically, factors underlying later stage BD and potential subgroups within this stage, to understand more about the later stage group and contribute to the measurement of stage. Methods An exploratory factor analysis was conducted using variables relating to current phenomenological aspects of illness, followed by cluster analyses based on the identified factors. Finally, the resultant clusters were compared based on course of illness variables. Results Fourteen extracted factors explained 57 percent of the variance. Latent structures aligned with current depressive symptoms, energy and interest, independence, occupational functioning, symptoms of anxiety, pain, elevated symptoms, interpersonal functioning, anger, perceptions of social connections, and perceptions of current medication effectiveness, cognitive issues, sleep issues, and sense of isolation. Two clusters were identified which differed significantly on each of these factors, and on a range of course of illness features including lifetime number of episodes, duration of illness and number of depressive hospitalizations. Conclusions Latent phenomenological features relevant to individuals in the later stage of BD were identified. Two clusters of individuals in later stage BD differ based on these features as well as course of illness, suggesting that there are distinct subgroups of individuals in the later stage of BD, distinguishable based on current phenomenology and illness history. However, findings are exploratory and therefore require confirmation before they can be applied clinically.

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Staging of Bipolar Disorder

Cited by 2 publications

References 124 publications

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Conceptualizing the later stage of bipolar disorder: Descriptive analyses from the ORBIT trial

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