Disability in Chronic Migraine Patients With Medication Overuse: Treatment Effects at 1‐Year Follow‐up

Grazzi, Licia; Andrasik, Frank; D’Amico, Domenico; Usai, Susanna; Kass, Steven J.; Bussone, Gennaro

doi:10.1111/j.1526-4610.2004.04127.x

Cited by 43 publications

(52 citation statements)

References 27 publications

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“…The patients arrived to the hospital at 9.00 am; they completed the infusional therapy and left the hospital at 4 pm. The treatment consisted of the following [5]: (1) intravenous hydration for a period of 5-6 days; (2) intravenous steroids for the first 5 days followed by oral prescription for other 5 days; (3) diazepam per os in 2 prescription per day; (4) ev or im metoclopramide or indomethacine when needed for intense rebound headache [5].…”

Section: Methodsmentioning

confidence: 99%

Day-hospital withdrawal for chronic migraine with medication overuse: results at 3 years follow-up

Grazzi¹,

Andrasik

Usai³

et al. 2013

Neurol Sci

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Patients with chronic headache and medication overuse are particularly difficult to treat, with no one approach being universally accepted. Some type of withdrawal program, however, is typically implemented before beginning a pharmacological prophylaxis treatment. Different withdrawal modalities have been performed for managing these patients: at first step, in-patient withdrawal has been confirmed effective in preceding clinical experiences. In recent years, new modalities for withdrawal have been developed as day-hospital setting. Purpose of this study was to determine the clinical course of a sample of chronic migraine patients with medication overuse 3 years after day-hospital withdrawal. A group of 202 patients were treated. Patients were suffering from chronic migraine with medication overuse according with IHS criteria. All patients were submitted to a day-hospital withdrawal and then they were followed with meetings every 3 months until the first year and then every 6 months until the last follow-up 3 years after withdrawal. Eighty patients achieved the last follow-up meeting 3 years after withdrawal. Patients clinically improved, significantly, both for days of headache per month and consumption of medications per month. From these results, the day-hospital setting for withdrawal, followed by periodic clinical meetings, seems to be effective for this category of patients to improve significantly at long-term headache frequency and analgesics intake.

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Section: Methodsmentioning

confidence: 99%

Day-hospital withdrawal for chronic migraine with medication overuse: results at 3 years follow-up

Grazzi¹,

Andrasik

Usai³

et al. 2013

Neurol Sci

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“…Regarding relapse, recent studies indicate that the highest risk is in the first 12 months, although different percentages are reported by various authors (22-44 % in Trucco et al [41]; 60-75 % in Zidverc et al [42] and Baumgartner et al [43]; or 40-60 % in Andrasik [15], Katsarava [44], Hagen et al [45], and Fritsche et al [46]). The risk decreases, however, if medication overuse is avoided for 12 months after withdrawal, and in general, MOH treatment is considered successful if the improvement obtained after withdrawal/detoxification with or without prophylaxis is maintained at 1-year follow-up [42,[47][48][49][50][51]. Several factors are considered a risk for relapse: male sex, a diagnosis of tension-type headache or mixed headache, frequency of the primary headache, higher severity of the migraine condition, long duration of drug overuse, greater number of previous prophylactic treatments, intake of combination analgesic products (e.g., one or more NSAIDs with caffeine or codeine) or of codeine-containing drugs, ergotamine or triptan withdrawal more than analgesic withdrawal, use of the same drug that has caused overuse, lower improvement after drug withdrawal, reduced sleep quality, and high levels of body pain and of disability score for chronic headache [12].…”

Section: Ichd-3 Beta 2013mentioning

confidence: 99%

Update on Medication-Overuse Headache and Its Treatment

Giamberardino

Mitsikostas

Martelletti

2015

Curr Treat Options Neurol

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Medication-overuse headache-i.e., a too-frequent consumption of acute headache medications leading to increased headache frequency and reduced effectiveness of acute and preventive treatments-is a serious medical condition whose pathophysiology still remains incompletely known, which is reflected into a lack of mechanism-based treatments. The first mandatory step in the therapeutic strategy remains withdrawal of the abused drug, preferably abrupt, in concomitance with a detoxification pharmacological regimen to lessen withdrawal symptoms. Intravenous hydration, antiemetics, corticosteroids (prednisone), tranquilizers (benzodiazepine), neuroleptics, and rescue medication (another analgesic than the overused) should be delivered in various combinations, on an inpatient (hospitalization and day hospital) basis or outpatient basis, depending on the characteristics of the specific patient and type of overuse. Inpatient withdrawal should be preferred in barbiturate and opioid overuse, in concomitant depression, or, in general, in patients who have difficulty in stopping the overused medication as outpatients. In contrast, in overuse limited to simple analgesics in highly motivated patients, without high levels of depression and/or anxiety, home detoxification should be chosen. Re-prophylaxis should immediately follow detoxification, ideally with local injections of onabotulinumtoxinA every 3 months or topiramate orally for at least 3 months. Adequate information to patients about the risks of a too-frequent consumption of symptomatic headache medications is essential and should constantly parallel treatment to help preventing relapse after detoxification and re-prophylaxis.

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“…В большинстве случа-ев рекомендуется полная и одномоментная отмена пре-парата. Постепенная отмена рекомендуется только при злоупотреблении барбитуратами или неудачных пред-шествующих попытках отмены [24]. Основные принципы European Academy Neurology (EAN) по отмене абузусного препарата представлены в таблице 2 [25].…”

Section: поведенческие факторыunclassified

Medication Overuse Headache: Practical Guidelines

Sergeev¹,

Парфенов²

2018

Med. sov.

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Disability in Chronic Migraine Patients With Medication Overuse: Treatment Effects at 1‐Year Follow‐up

Cited by 43 publications

References 27 publications

Day-hospital withdrawal for chronic migraine with medication overuse: results at 3 years follow-up

Day-hospital withdrawal for chronic migraine with medication overuse: results at 3 years follow-up

Update on Medication-Overuse Headache and Its Treatment

Medication Overuse Headache: Practical Guidelines

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