Dirty necrosis in renal cell carcinoma is associated with <scp>NETosis</scp> and systemic inflammation

Kuroe, Takashi; Watanabe, Reiko; Morisue, Ryo; Miyazaki, Saori; Kojima, Masaru; Murata, Shawhay Charles; Nakai, Tokiko; Taki, Tetsuro; Sakashita, Shingo; Sakamoto, Naoya; Matsubara, Nobuaki; Masuda, Hitoshi; Ushiku, Tetsuo; Ishii, Genichiro

doi:10.1002/cam4.5249

Cited by 8 publications

(7 citation statements)

References 31 publications

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“…Furthermore, reticular structures were observed around the cellular decay products. 19 Therefore, we focused on NETs, which have been implicated in cancer progression and metastasis 26 29,30 the present study found no association between systemic inflammation and the presence of DN (Table S4). This may be because MLCR has a smaller tumor volume than the primary tumor.…”

Section: The Association Of Netosis With Dnmentioning

confidence: 58%

Clinicopathological features and prognostic impact of dirty necrosis in metastatic lung cancers from the colon and rectum

et al. 2022

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Dirty necrosis (DN) is a form of tumor necrosis (TN) with prominent neutrophil infiltration and cell detritus in the necrotic foci. This study aimed to characterize the clinicopathological features of DN in metastatic lung cancers of the colon and rectum (MLCRs). A total of 227 patients who underwent pulmonary metastasectomy and complete resection for MLCR were included in this study. TN was evaluated using digitally scanned resection specimens. These slides were immunostained for biomarkers of NETosis (citrullinated histone H3 [citH3] and myeloperoxidase [MPO]), and the area positive for citH3 and MPO was further quantified. TN was observed in 216 cases (95.2%), and 54 (25.0%) of these cases had DN. The presence of TN was not associated with a worse prognosis; however, patients with DN had a significantly shorter overall survival than those without DN ( p < 0.01). Furthermore, the presence of DN was a poor prognostic factor in both the univariate and multivariate analyses. Immunohistochemical analysis revealed that the percentage of citH3‐positive and MPO‐positive areas in the DN‐positive cases was significantly higher than that in the DN‐negative cases ( p < 0.01 and p < 0.01, respectively). In surgically resected MLCR, DN is the characteristic TN subtype associated with poor prognosis and neutrophil extracellular traps (NETs).

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Section: The Association Of Netosis With Dnmentioning

confidence: 58%

Clinicopathological features and prognostic impact of dirty necrosis in metastatic lung cancers from the colon and rectum

et al. 2022

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“…This is composed of the area of tumor necrosis with which neutrophilic infiltrate is associated. Its presence is associated with the phenomena of systemic inflammation [87]. We identified an association between necrosis and acute intratumoral inflammatory infiltrate (p=0.008), but without a correlation between them and the systemic inflammatory syndrome (p=0.872).…”

Section: Discussionmentioning

confidence: 74%

Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas

Vamesu,

Ursica,

Milea

et al. 2024

Preprint

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Background and Objectives: Renal cell carcinomas and upper tract urothelial carcinomas are types of malignancies that originate in the kidneys. Each of these examples shows an increasing trend in the frequency and the mortality rate. This study aims to comprehensively define carcinomas by analysing clinical, paraclinical, and histological aspects to predict aggressiveness and mortality. Materials and Methods: We conducted a retrospective investigation on a group of patients suspected with kidney cancers. Results: We identified 188 cases. We observed a higher mortality rate and older age in individuals with urothelial carcinomas. Anemia, acute kidney injury, hematuria and perineural invasion were the main risk factors that predicted their mortality. Tumour size in renal cell carcinomas correlates with the presence of necrosis and sarcomatoid areas. Factors that indicate a higher rate of death are older age, exceeding of the renal capsule, the lesion that includes the entire kidney, lymphovascular invasion, acute kidney injury, and anemia. Conclusions: Even if they originate at the renal level, and the clinical-paraclinical picture is similar, the histopathological characteristics make the difference. In addition, to these are added the previously mentioned common parameters that can represent important prognostic factors. In conclusion, the characteristics commonly identified in one type of cancer may act as risk factors for the other tumor. The detected data include threshold values and risk factors, making a significant contribution to the existing literature.

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“…ACO1 and IREB2 downregulation were associated with poor prognosis, autophagy-related ferroptosis, and immune infiltration in KIRC [93]. Kuroe et al [94] revealed that dirty necrosis in RCC was related to NETosis and systemic inflammation. By decreasing glutathione consumption, metallothionein 1 G (MT1G) upregulation negatively regulates ferroptosis in ccRCC [95].…”

Section: Ferroptosis and Kidney Diseasesmentioning

confidence: 99%

Novel Insight into Ferroptosis in Kidney Diseases

Liu¹,

Liu²,

Zhou³

et al. 2023

Am J Nephrol

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Background: Various kidney diseases such as acute kidney injury, chronic kidney disease, polycystic kidney disease, renal cancer, and kidney stones, are an important part of the global burden, bringing a huge economic burden to people around the world. Ferroptosis is a type of nonapoptotic iron-dependent cell death caused by the excess of iron-dependent lipid peroxides and accompanied by abnormal iron metabolism and oxidative stress. Over the past few decades, several studies have shown that ferroptosis is associated with many types of kidney diseases. Studying the mechanism of ferroptosis and related agonists and inhibitors may provide new ideas and directions for the treatment of various kidney diseases. Summary: In this review, we discuss the differences between ferroptosis and other types of cell death such as apoptosis, necroptosis, pyroptosis, cuprotosis, pathophysiological features of the kidney, and ferroptosis-induced kidney injury. We also provide an overview of the molecular mechanisms involved in ferroptosis and events that lead to ferroptosis. Furthermore, we summarize the possible clinical applications of this mechanism among various kidney diseases. Key Message: The current research suggests that future therapeutic efforts to treat kidney ailments would benefit from a focus on ferroptosis.

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Dirty necrosis in renal cell carcinoma is associated with NETosis and systemic inflammation

Cited by 8 publications

References 31 publications

Clinicopathological features and prognostic impact of dirty necrosis in metastatic lung cancers from the colon and rectum

Clinicopathological features and prognostic impact of dirty necrosis in metastatic lung cancers from the colon and rectum

Same Organ, Two Cancers: Complete Analysis of Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas

Novel Insight into Ferroptosis in Kidney Diseases

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