Novel Insight into Ferroptosis in Kidney Diseases

Abstract

<b><i>Background:</i></b> Various kidney diseases such as acute kidney injury, chronic kidney disease, polycystic kidney disease, renal cancer, and kidney stones, are an important part of the global burden, bringing a huge economic burden to people around the world. Ferroptosis is a type of nonapoptotic iron-dependent cell death caused by the excess of iron-dependent lipid peroxides and accompanied by abnormal iron metabolism and oxidative stress. Over the past few decades, several studies have shown that ferroptosis is associated with many types of kidney diseases. Studying the mechanism of ferroptosis and related agonists and inhibitors may provide new ideas and directions for the treatment of various kidney diseases. <b><i>Summary:</i></b> In this review, we discuss the differences between ferroptosis and other types of cell death such as apoptosis, necroptosis, pyroptosis, cuprotosis, pathophysiological features of the kidney, and ferroptosis-induced kidney injury. We also provide an overview of the molecular mechanisms involved in ferroptosis and events that lead to ferroptosis. Furthermore, we summarize the possible clinical applications of this mechanism among various kidney diseases. <b><i>Key Message:</i></b> The current research suggests that future therapeutic efforts to treat kidney ailments would benefit from a focus on ferroptosis.

Baicalein improves renal interstitial fibrosis by inhibiting the ferroptosis in vivo and in vitro

“…It was found that ferroptosis played an important role in acute kidney injury, renal cancer, and other kidney-related diseases , however, its underlying mechanism has not been fully elucidated [ 18 , 19 ]. Cystine/glutamate antiporter (System Xc) is an important intracellular antioxidant system, including two subunits termed SLC7A11 and SLC3A2L, which can take up cystine and excrete glutamate [ 20 ].…”

Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

“…In about ten years of research investigations, ferroptosis emerged as a type of cell death with a pivotal role in preventing or even facilitating the progression of many diseases (reviewed in [ 1 , 2 , 3 ]). In particular, ferroptosis is now considered a good therapeutic option to treat multiple forms of cancer and arrest tumor growth [ 3 , 4 , 5 ], as well as a causal factor in neurodegenerative disorders [ 6 ], senescence/aging [ 7 ], different blood diseases [ 8 ], and kidney- and ischemia-reperfusion injuries [ 9 , 10 ].…”

Cell death‑related molecules and targets in the progression of urolithiasis (Review)

“…Cell death plays key roles in the pathogenesis and treatment of a variety of uropathies, including cancer, urinary tract infections and urolithiasis ( 8 ). Apoptosis, necroptosis, pyroptosis and ferroptosis induce acute kidney injury (AKI) or chronic kidney injury, which is associated with nephrolithiasis ( 9 , 10 ).…”