Directly immersible silicon photonic probes: Application to rapid SARS-CoV-2 serological testing

Angelopoulou, Μichailia; Makarona, Eleni; Salapatas, Alexandros; Μισιακός, Κωνσταντίνος; Synolaki, Evgenia; Ioannidis, Anastasios; Chatzipanagiotou, Stylianos; Ritvos, Mikael A; Pasternack, Arja; Ritvos, Olli; Petrou, Panagiota; Kakabakos, Sotirios

doi:10.1016/j.bios.2022.114570

Cited by 13 publications

(7 citation statements)

References 39 publications

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“…The immersible photonic sensors (US Patent 11,119,040; EPO Patent Application: EP3532825A1), their principle of operation, and the accompanying reader configuration have been described in detail in [34]. Briefly, the silicon-based photonic sensors were fabricated at the clean-room facility of the Nanotechnology and Microsystems Laboratory, Institute of Nanoscience and Nanotechnology, NCSR "Demokritos", on 4″ wafers with a 5 μm thick silicon dioxide bottom cladding layer and an LPCVD-grown silicon nitride layer (SiMat, Kaufering, Germany).…”

Section: Immersible Photonic Sensors and Readermentioning

confidence: 99%

“…It employs a novel type of immersible Si-based photonic sensor using Broad-band Mach-Zehnder Interferometry (BB-MZIs) as the principle of operation [31][32][33]. The two most important novelties behind this type of sensor make it stand out and render it suitable for this study, as presented in detail in [34] and as will be further analyzed in Section 2.2: (1) Contrary to "traditional" biosensors, they do not require any microfluidics, but can be directly immersed into the analytes. This feature alleviates the need for tubes and pumps.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, the sensors are immersed in basil pulps at the hydroponic installation site, and the output signal is a dynamically shifting spectrum. However, signal analysis is simplified by using Fast Fourier Transform (FFT) to record a single variable: the phase change over time due to biomolecular interactions [34]. The immersible sensors were originally designed as a rapid, portable, and cost-effective tool for biodiagnostics and food safety determinations, and they have been appropriately functionalized with biorecognition molecules for specific analytes in these contexts [34,35].…”

Section: Introductionmentioning

confidence: 99%

“…However, signal analysis is simplified by using Fast Fourier Transform (FFT) to record a single variable: the phase change over time due to biomolecular interactions [34]. The immersible sensors were originally designed as a rapid, portable, and cost-effective tool for biodiagnostics and food safety determinations, and they have been appropriately functionalized with biorecognition molecules for specific analytes in these contexts [34,35]. In this work, however, the BB-MZI sensing areas have not been modified with any biorecognition molecules, nor have they undergone any surface treatment.…”

Section: Introductionmentioning

confidence: 99%

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Determining the Nutrient Content of Hydroponically-Cultivated Microgreens with Immersible Silicon Photonic Sensors: A Preliminary Feasibility Study

Christofi

Margariti

Salapatas

et al. 2023

Sensors

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Microgreens have gained attention for their exceptional culinary characteristics and high nutritional value. The present study focused on a novel approach for investigating the easy extraction of plant samples and the utilization of immersible silicon photonic sensors to determine, on the spot, the nutrient content of microgreens and their optimum time of harvest. For the first time, it was examined how these novel sensors can capture time-shifting spectra caused by the molecules’ dynamic adhesion onto the sensor surface. The experiment involved four types of microgreens (three types of basil and broccoli) grown in a do-it-yourself hydroponic installation. The sensors successfully distinguished between different plant types, showcasing their discriminative capabilities. To determine the optimum harvest time, this study compared the sensor data with results obtained through standard analytical methods. Specifically, the total phenolic content and antioxidant activity of two basil varieties were juxtaposed with the sensor data, and this study concluded that the ideal harvest time for basil microgreens was 14 days after planting. This finding highlights the potential of the immersible silicon photonic sensors for potentially replacing time-consuming analytical techniques. By concentrating on obtaining plant extracts, capturing time-shifting spectra, and assessing sensor reusability, this research paves the way for future advancements in urban farming.

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Section: Immersible Photonic Sensors and Readermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Determining the Nutrient Content of Hydroponically-Cultivated Microgreens with Immersible Silicon Photonic Sensors: A Preliminary Feasibility Study

Christofi

Margariti

Salapatas

et al. 2023

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…The possibility of integrating a broadband light source, a planar interferometer and a spectral spectrum detection system on one substrate was also shown [16]. Recently, a paper [17] was published in which a broadband Mach-Zehnder interferometer enabled the detection of SARS-CoV-2 antibodies.…”

Section: Introductionmentioning

confidence: 99%

Influence of Ion Exchange Process Parameters on Broadband Differential Interference

Gut

Błahut

2023

Sensors

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The paper presents theoretical analyses and experimental investigations of broadband differential interference in planar gradient waveguides made via K+-Na+ ion exchange in BK-7 glass. This technology, due to its large polarimetric dispersion, is especially useful for applications in differential interferometry. We discuss the influence of technological parameters on the operation characteristics of the structure in terms of sensor applications. The refractive index variation in the measured external surroundings affects the modal properties of TE and TM modes and the spectral distribution at the output of the differential interferometer. The optical system described in this work has been designed specifically for use in biological systems where variations in the index of refraction need to be measured.

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Hazelnut proteins detection in cookies using an immersible label-free photonic chip sensor

Angelopoulou,

Smits,

Makarona

et al. 2025

Food Control

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Directly immersible silicon photonic probes: Application to rapid SARS-CoV-2 serological testing

Cited by 13 publications

References 39 publications

Determining the Nutrient Content of Hydroponically-Cultivated Microgreens with Immersible Silicon Photonic Sensors: A Preliminary Feasibility Study

Determining the Nutrient Content of Hydroponically-Cultivated Microgreens with Immersible Silicon Photonic Sensors: A Preliminary Feasibility Study

Influence of Ion Exchange Process Parameters on Broadband Differential Interference

Hazelnut proteins detection in cookies using an immersible label-free photonic chip sensor

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