Directionality of corticomuscular coupling in essential tremor and cortical myoclonic tremor

Sharifi, Sarvi; Luft, Frauke; Potgieter, S.; Heida, Tjitske; Mugge, Winfred; Schouten, Alfred C.; Bour, L.J.; Rootselaar, A.F. van

doi:10.1016/j.clinph.2021.04.011

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…These physiological studies are consistent with clinical observations that discrete strokes within this loop can disrupt tremor in ET patients, and the locations of strokes include primary motor cortex, pontine nuclei, cerebellum, dentate nucleus, posterior part of ventrolateral nucleus and ventral intermedius nucleus of the thalamus [43][44][45][46]. In addition, the combination of EEG and EMG to study cortico-muscular coherence in ET patients reveals the co-involvement of primary motor cortex and the cerebellum [47,48]. Since the converging evidence indicates the critical role of the cerebellum in ET, a recent study showed enhanced cerebellar oscillatory activity can be directly recorded by cerebellar EEG in ET patients [41].…”

Section: Mapping Brain Circuits Of Etsupporting

confidence: 82%

Essential tremor: Clinical perspectives and pathophysiology

Pan

Kuo

2022

Journal of the Neurological Sciences

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Section: Mapping Brain Circuits Of Etsupporting

confidence: 82%

Essential tremor: Clinical perspectives and pathophysiology

Pan

Kuo

2022

Journal of the Neurological Sciences

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“…Patients were allowed to rest sufficiently in between, as indicated by themselves. Details of the EMG analyses methods, including coherence analysis, were described before and are summarized in the supplementary data 41,42 . Tremor frequency and intermuscular coherence peak frequency were determined using an in‐house developed Matlab coherence tool based on NeuroSpec toolbox 41 …”

Section: Methodsmentioning

confidence: 99%

Deep Brain Stimulation for Orthostatic Tremor: An Observational Study

Babeliowsky,

Bot,

Potters

et al. 2024

Movement Disord Clin Pract

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BackgroundPrimary orthostatic tremor (OT) can affect patients’ life. Treatment of OT with deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (Vim) is described in a limited number of patients. The Vim and posterior subthalamic area (PSA) can be targeted in a single trajectory, allowing both stimulation of the Vim and/or dentatorubrothalamic tract (DRT). In essential tremor this is currently often used with positive effects.ObjectiveTo evaluate the efficacy of Vim/DRT‐DBS in OT‐patients, based on standing time and Quality of Life (QoL), also on the long‐term. Furthermore, to relate stimulation of the Vim and DRT, medial lemniscus (ML) and pyramidal tract (PT) to beneficial clinical and side‐effects.MethodsNine severely affected OT‐patients received bilateral Vim/DRT‐DBS. Primary outcome measure was standing time; secondary measures included self‐reported measures, neurophysiological measures, structural analyses, surgical complications, stimulation‐induced side‐effects, and QoL up to 56 months. Stimulation of volume of tissue activated (VTA) were related to outcome measures.ResultsAverage maximum standing time increased from 41.0 s ± 51.0 s to 109.3 s ± 65.0 s after 18 months, with improvements measured in seven of nine patients. VTA (n = 7) overlapped with the DRT in six patients and with the ML and/or PT in six patients. All patients experienced side‐effects and QoL worsened during the first year after surgery, which improved again during long‐term follow‐up, although remaining below age‐related normal values. Most patients reported a positive effect of DBS.ConclusionVim/DRT‐DBS improved standing time in patients with severe OT. Observed side‐effects are possibly related to stimulation of the ML and PT.

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“…The cerebellum and thalamus were not measured in this study. Interestingly, in ET an efferent cortical drive is also lacking in the majority of patients, and cortico-muscular coupling is predominantly present in an afferent direction [42]. However, in ET no distinction was made between tremor onset and tremor maintenance.…”

Section: The Basal Ganglia and Tremormentioning

confidence: 99%

Connecting tremors – a circuits perspective

Buijink

Rootselaar

Helmich³

2022

Current Opinion in Neurology

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Purpose of reviewTremor is one of the most prevalent movement disorders in clinical practice. Here, we review new insights in the pathophysiology of tremor. We focus on the three most common tremor disorders: essential tremor (ET), dystonic tremor syndrome (DTS), and Parkinson's disease (PD) tremor.Recent findingsConverging evidence suggests that ET, DTS, and PD tremor are all associated with (partly) overlapping cerebral networks involving the basal ganglia and cerebello-thalamo-cortical circuit. Recent studies have assessed the role of these networks in tremor by measuring tremor-related activity and connectivity with electrophysiology and neuroimaging, and by perturbing network components using invasive and noninvasive brain stimulation. The cerebellum plays a more dominant and causal role in action tremors than in rest tremor, as exemplified by recent findings in ET, DTS, and re-emergent tremor in PD. Furthermore, the role of the cerebellum in DTS is related to clinical differences between patients, for example, whether or not the tremor occurs in a dystonic limb, and whether the tremor is jerky or sinusoidal.SummaryInsight into the pathophysiological mechanisms of tremor may provide a more direct window into mechanism-based treatment options than either the etiology or the clinical phenotype of a tremor syndrome.

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Directionality of corticomuscular coupling in essential tremor and cortical myoclonic tremor

Cited by 6 publications

References 36 publications

Essential tremor: Clinical perspectives and pathophysiology

Essential tremor: Clinical perspectives and pathophysiology

Deep Brain Stimulation for Orthostatic Tremor: An Observational Study

Connecting tremors – a circuits perspective

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