Directed DNA Metallization

Burley, Glenn A.; Gierlich, Johannes; Mofid, Mohammad Reza; Nir, Hadar; Tal, Shay; Eichen, Yoav; Carell, Thomas

doi:10.1021/ja055517v

Cited by 283 publications

(196 citation statements)

References 16 publications

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“…139 To the target sites in DNA, alkyne-attached pyrimidine was first incorporated by using DNA polymerase. Then, the alkyne groups were reacted with aldehyde-bound azides using Cu(I)-catalyzed click reaction, and the selected parts in DNA were adorned with aldehyde functions.…”

Section: Dna Nanoarchitectonicsmentioning

confidence: 99%

Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

Komiyama

Yoshimoto

Sisido

et al. 2017

Bulletin of the Chemical Society of Japan

275

131

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In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA nanoarchitectonics and cellmacromolecular nanoarchitectonics, both of which are basically controlled by chemical strategies. The former DNA-based approach would represent the precise nature of the nanoarchitectonics based on the strict or "digital" molecular recognition between nucleic bases. This part includes functionalization of single DNAs by chemical means, modification of the main-chain or side-chain bases to achieve stronger DNA binding, DNA aptamers and DNAzymes. It also includes programmable assemblies of DNAs (DNA Origami) and their applications for delivery of drugs to target sites in vivo, sensing in vivo, and selective labeling of biomaterials in cells and in animals. In contrast to the digital molecular recognition between nucleic bases, cell membrane assemblies and their interaction with macromolecules are achieved through rather generic and "analog" interactions such as hydrophobic effects and electrostatic forces. This cell-macromolecular nanoarchitectonics is discussed in the latter part of this review. This part includes bottom-up and top-down approaches for constructing highly organized cell-architectures with macromolecules, for regulating cell adhesion pattern and their functions in twodimension, for generating three-dimensional cell architectures on micro-patterned surfaces, and for building synthetic/natural macromolecular modified hybrid biointerfaces.

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Section: Dna Nanoarchitectonicsmentioning

confidence: 99%

Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

Komiyama

Yoshimoto

Sisido

et al. 2017

Bulletin of the Chemical Society of Japan

275

131

View full text Add to dashboard Cite

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“…The underlying motivation for exploring this original design was based on a previous observation that this ligand was used to form Ag nanostructures when covalently attached to DNA duplexes and exposed to Tollens' reagent. [27] To gain further insight into how the ligand structure could influence AgNP formation, ligands were prepared in which the resorcinol core (as present in 1) was replaced with phloroglucinol [ Figure 1 (b)]. This change subtly alters the triazole regiochemistry and intertriazole distance in the southern part of the ligand.…”

Section: Design Of Sugar Triazole Ligands 2-7mentioning

confidence: 99%

Defining the Structural Parameters of Triazole Ligands in the Templated Synthesis of Silver Nanoparticles

et al. 2014

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This manuscript describes a one-pot method for the synthesis of size-and shape-selected silver nanoparticles (AgNPs) using Tollens' reagent [Ag(NH 3 ) 2 OH] as the silver source. Sugar triazole ligands facilitate the formation of monodisperse AgNPs in which the size and shape can be controlled according to the reaction conditions. Increasing the size of the ligand reduces size tunability but enhances colloidal stability in high-salt buffers. A key conclusion from this study is

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“…Genes of interest can be selectively metallized via the incorporation of modified triphosphates [42]. These triphosphates bear functions that can be further derivatized with aldehyde groups via the use of click chemistry.…”

Section: Trna Computing Unitsmentioning

confidence: 99%