Direct-writing Process and in vivo Evaluation of Prevascularized Composite Constructs for Muscle Tissue Engineering Application

Lian, Qin; Zhao, Tingze; Jiao, Tian; Huyan, Yige; Gu, Heng; Gao, Lin

doi:10.1007/s42235-020-0037-0

Cited by 15 publications

(4 citation statements)

References 35 publications

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“…Benefiting from the advancements in tissue engineering, significant progress is anticipated in the fabrication, cultivation, and maintenance of living materials. For example, the incorporation of vascular networks [139][140][141] and nerve tissue [142] is expected to enhance the existing culture conditions and enable the construction of multiscale, high-performance muscle tissue. The utilization of cutting-edge technologies such as "robot skin" [143] is poised to move muscle tissue out of the laboratory environment and promote the development of biosyncretic robots that can operate in gas environments.…”

Section: Fabrication Cultivation and Maintenance Of Living Materialsmentioning

confidence: 99%

Biosyncretic Robots Actuated by Living Materials

Yang,

Zhang,

Wang

et al. 2023

Adv Materials Technologies

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In recent years, biosyncretic robots, a novel type of robot that integrates living and artificial materials, have gained significant attention. Biosyncretic robots are expected to leverage the advantages provided by living materials and offer a new approach to address the challenges faced by traditional robots, such as biocompatibility, intrinsic safety, and miniaturization. Therefore, this review aims to provide an overview of the current state of development of biosyncretic robots. First, the existing research on biosyncretic robots based on commonly used living materials is systematically categorized and introduced, including cardiomyocytes, skeletal muscle cells, insect dorsal vascular tissue, and microorganisms. Subsequently, their potential in the fields of in vivo medical diagnosis and treatment, organ‐on‐a‐chip, tissue engineering, environmental monitoring, and postdisaster rescue in detail is also discussed. Finally, the current challenges faced by biosyncretic robotic research, including establishing theoretical models, fabrication, cultivation, and maintenance of living materials, controllability, versatility, artificial material, and entering the human body or leaving the laboratory, are examined. This review summarizes the cutting‐edge progress of biosyncretic robots and provides insights into their future development.

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Section: Fabrication Cultivation and Maintenance Of Living Materialsmentioning

confidence: 99%

Biosyncretic Robots Actuated by Living Materials

Yang,

Zhang,

Wang

et al. 2023

Adv Materials Technologies

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“…Among the plentiful biomaterials, gelatin (Gel) and sodium alginate (Alg) have drawn extensive attention in biofabrication. Previously, our group has been committed to optimize the extrusion direct-writing printing process for them as a composite bioink [ 16 , 17 ]. Gelatin could be quickly gelled with temperature changes or with the participation of transglutaminase (TG) enzymes and the internal spatial structure could maintain for a long time.…”

Section: Introductionmentioning

confidence: 99%

Functionalizing multi-component bioink with platelet-rich plasma for customized in-situ bilayer bioprinting for wound healing

Zhao

Wang

Zhang

et al. 2022

Materials Today Bio

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“…Biofabricated constructs should aim to mimic these 3D cellular interactions that ultimately affect functional activity [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. The field of biofabrication aims to replicate the native hierarchical tissue and organ structure by placing biomaterials and cells precisely into a 3D space, creating living constructs [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. These 3D models of native organ structures can be captured from magnetic resonance imaging (MRI), computed tomography (CT) or designed in computer-aided design (CAD) programs and translated to control biofabrication patterning [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Significant progress has been made to translate the knowledge of native tissues’ structural and functional properties to lab-made scaffolds [ 59 , 60 , 61 ]. Controlled scaffold cues have been shown to influence and drive cell behaviour towards functioning engineered tissues [ 25 , 26 , 27 , 28 , 29 , 30 ]. This demonstrates the importance of controllable and engineered extracellular cues; without access to reproducible materials, it is challenging to fully control cell–scaffold interactions and manufacture quality-controlled matrices for tissue and organ engineering.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Peptide Biomaterials for Biofabrication

et al. 2021

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Biofabrication using well-matched cell/materials systems provides unprecedented opportunities for dealing with human health issues where disease or injury overtake the body’s native regenerative abilities. Such opportunities can be enhanced through the development of biomaterials with cues that appropriately influence embedded cells into forming functional tissues and organs. In this context, biomaterials’ reliance on rigid biofabrication techniques needs to support the incorporation of a hierarchical mimicry of local and bulk biological cues that mimic the key functional components of native extracellular matrix. Advances in synthetic self-assembling peptide biomaterials promise to produce reproducible mimics of tissue-specific structures and may go some way in overcoming batch inconsistency issues of naturally sourced materials. Recent work in this area has demonstrated biofabrication with self-assembling peptide biomaterials with unique biofabrication technologies to support structural fidelity upon 3D patterning. The use of synthetic self-assembling peptide biomaterials is a growing field that has demonstrated applicability in dermal, intestinal, muscle, cancer and stem cell tissue engineering.

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Direct-writing Process and in vivo Evaluation of Prevascularized Composite Constructs for Muscle Tissue Engineering Application

Cited by 15 publications

References 35 publications

Biosyncretic Robots Actuated by Living Materials

Biosyncretic Robots Actuated by Living Materials

Functionalizing multi-component bioink with platelet-rich plasma for customized in-situ bilayer bioprinting for wound healing

Enhancing Peptide Biomaterials for Biofabrication

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