Direct Thrombin Inhibitors

Highly flexible and stable aptamer-caged nanoparticles for control of thrombin activity

“…25,26 Anticoagulant drugs that are direct thrombin inhibitors (DTIs), such as heparin, warfarin and bivalirudin, are often used to modulate blood coagulation. [27][28][29][30][31] However, they have side effects such as excessive bleeding, thrombocytopenia, narrow therapeutic windows and highly variable dose-response relationships among individuals. [32][33][34][35] As an alternative, aptamers have been shown to be potential hemostasis-factor-specific anticoagulants, with advantages of high affinity, non-immunogenicity, and nontoxicity.…”