Dabigatran etexilate versus warfarin as the oral anticoagulant of choice? A review of clinical data

K.W., Terry; Yan, Bryan P.; Lam, Yat‐Yin

doi:10.1016/j.pharmthera.2010.09.005

Cited by 27 publications

(26 citation statements)

References 54 publications

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“…10 While both activated partial thromboplastin and prothrombin times are prolonged, these measures are not sensitive in patients taking dabigatran. 11 Ecarin clotting time is more sensitive but not widely available in the clinical setting. 12 Dabigatran (Pradaxa) has no reversal agent and little evidence supporting procoagulant strategies.…”

Section: Discussionmentioning

confidence: 99%

Epidural Hematoma and Intraoperative Hemorrhage in a Spine Trauma Patient on Pradaxa (Dabigatran)

Truumees

Gaudu

Dieterichs

et al. 2012

Spine

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As dabigatran (Pradaxa) has recently been approved by the Food and Drug Administration, many spine specialists are not familiar with this agent. Many of the reversal agents (e.g., vitamin K and protamine), useful for other classes of anticoagulants, have no impact on Pradaxa. Similarly, prothrombin time and partial thromboplastin times have limited utility in estimating the patient's true clotting status. The purpose of this case report is to alert spine specialists to this drug and its implications on spine care. The drug's pharmacokinetics, clinical assessment of clotting status, and reversal options are discussed.

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Section: Discussionmentioning

confidence: 99%

Epidural Hematoma and Intraoperative Hemorrhage in a Spine Trauma Patient on Pradaxa (Dabigatran)

Truumees

Gaudu

Dieterichs

et al. 2012

Spine

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show abstract

“…Le dabigatran inhibe la thrombine de manière spécifique et directe [2]. Le taux de liaison aux protéines plasmatiques du dabigatran est de 35 % [1].…”

Section: Dabigatran (Pradaxa ® )unclassified

Anticoagulants oraux directs chez la personne âgée, point de vue de l’anesthésiste-réanimateur

Noll

Burgin

Thibaud

et al. 2015

cah. année gerontol.

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“…Ein Antidot bei Überdosierung ist nicht verfügbar. Daten zur Wirksamkeit als orales TVT-Prophylaktikum bei hospitalisierten Patienten liegen derzeit nicht vor [34].…”

Section: Direkte Thrombininhibitorenunclassified

Thromboseprophylaxe beim geriatrischen Patienten

Roller

Feichtinger

2012

Z Gerontol Geriat

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Dabigatran etexilate versus warfarin as the oral anticoagulant of choice? A review of clinical data

Cited by 27 publications

References 54 publications

Epidural Hematoma and Intraoperative Hemorrhage in a Spine Trauma Patient on Pradaxa (Dabigatran)

Epidural Hematoma and Intraoperative Hemorrhage in a Spine Trauma Patient on Pradaxa (Dabigatran)

Anticoagulants oraux directs chez la personne âgée, point de vue de l’anesthésiste-réanimateur

Thromboseprophylaxe beim geriatrischen Patienten

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