Direct synthesis of quinazolinones by acceptorless dehydrogenative coupling of o-aminobenzamide and alcohols by heterogeneous Pt catalysts

Abstract

HBEA supported Pt metal nanoclusters effectively catalyze direct dehydrogenative synthesis of quinazolinones from o-aminobenzamide and alcohols under promoter-free conditions.

Base‐Free Tandem Cyclooxidative Synthesis of Quinazolinones with GdxMn–ZnO (M= Mo, V, W) Catalysts

“…Further, catalyst loading from 5% to 25% was studied for the impact on product yield. It is found that 5,10,15,20 and 25 wt % loading of the catalyst give 45, 70, 76, 90, 91% yields respectively. 20 wt % of the catalyst was found to be the best catalyst loading to obtain maximum product yield.…”

“…),harsh reaction conditions, multistep synthesis, generation of stoichiometric amount of wastes, difficulty in product isolation, low product yields, non-recyclability of the catalysts and low reaction rates. [5][6][7][8][9] Mixed metal oxides (MMOs) formulate an important class of solid acid catalysts. They are decorated with multiple type of active sites and exhibit variable physico chemical properties.…”

Facile Non‐Transition Metal‐Catalyzed Synthesis of 2‐Thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one Derivatives via One‐Pot Multicomponent Reactions

“…Despite the numerous properties of quinazolinones, developing an efficient and simple synthetic method for these compounds has been a challenge, A common strategy for the synthesis of quinazolinone derivatives is the reaction of aldehydes with aminobenzoic acid, such as 2‐aminobenzamide,, 2‐aminobenzonitrile and 2‐aminobenzoic acid . Another strategy is the reactions between 2‐aminobenzamide and primary alcohols in the presence of Pt and Pd catalysts. In addition, 2‐halobenzamides, and 2‐haloanilines have been used to synthesize quinazolinones.…”

Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters

“…A similar oxidative condensation of primary alcohols with 2-aminobenzamide to generate quinazolinones was promoted by TBHP alone [ 22 ] and together with iodine and dimethyl sulfoxide [ 23 , 24 ]. Numerous metals such as manganese [ 25 ], iron [ 26 ], nickel [ 27 ], zinc [ 28 ], ruthenium [ 29 ], iridium [ 30 ], and platinum [ 31 ] in conjunction with TBHP were also reported to promote this reaction. The option of using primary alcohols for this transformation dramatically increased the scope of the synthesis due to the vast array of available substrates.…”