Direct Synthesis of Polylactide (PLA)-Chlorphenesin Prodrug and Optimization Thereof with the Aid of DOE

Sebai, Agnieszka; Ruśkowski, Paweł; Bijak, Vanessa; Gadomska‐Gajadhur, Agnieszka; Kruk, Aleksandra; Synoradzki, Ludwik

doi:10.1021/acs.oprd.7b00266

Cited by 14 publications

(16 citation statements)

References 13 publications

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“…The reactors are made of high-quality acid-resistant steel and placed in a heating jacket, which ensures chemical resistance and good heat transfer. The MultiMax system ensured uniform mixing by controlling the mechanical stirrer and the same temperature profile in the reaction. ,, …”

Section: Methodsmentioning

confidence: 99%

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Matyszczak

Wrzecionek

Gadomska‐Gajadhur

et al. 2020

Org. Process Res. Dev.

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Based on the measurement of infrared spectra carried out during the polycondensation of sebacic acid with glycerol at temperatures of 130, 150, and 170 °C, a kinetic model was created that was in very good agreement with the experimental data. The kinetic model consists of elementary reactions and their kinetic rate constants. The energy of activation of elementary reactions was determined. The numerical solution of the system of differential equations based on elementary reactions of the model allows prediction of changes in considerations of reagents over time and an approximate estimation of the molar mass distribution of polymers in the reaction product. The results of the simulations are in line with the results of the testing experiments and allow us to optimize the course of the reaction, among others, to determine the reaction time to the desired conversion of monomers at a specific size distribution in the product. This is the first work to determine the kinetics of polycondensation of sebacic acid with glycerol based on a kinetic model.

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Section: Methodsmentioning

confidence: 99%

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Matyszczak

Wrzecionek

Gadomska‐Gajadhur

et al. 2020

Org. Process Res. Dev.

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“…Its main advantage is using the smallest possible number of experiments to collect the maximum of information about the process. Thereby, time, work, and material consumption are minimized, while maximizing the amount of obtained results 24‐27 …”

Section: Introductionmentioning

confidence: 99%

Design of experiments‐based strategy for development and optimization of polylactide membranes preparation by wet inversion phase method

Gadomska‐Gajadhur

Kruk

Wierzchowski

et al. 2021

Polymers for Advanced Techs

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Cells‐containing scaffolds made of biomaterial are modern hybrid constructs which allow regeneration or reconstruction of damaged connective tissue, e.g. cartilage or bone. The basic aim of the study was to recognize the impact of the scaffold production parameters (i.e. type of applied pore precursor, its concentration) on morphology and mechanical properties of polylactide (PLLA) membrane‐based constructs, as well as their biocompatibility exhibited as cellular response. Design of experiments (DoE) strategy has been applied to quantitatively recognize the effects of synthesis parameters on PLLA‐membrane properties. Two independent correlations have been introduced to provide the influence of the synthesis parameters on the pore size, as well as the Young's modulus identifying the surface properties of scaffolds. PLLA membrane‐based scaffolds characterized by average pore diameter exceeded 100 microns and average Young's modulus exceeded 10 MPa have been obtained. The evaluation of scaffolds biocompatibility has been performed due to comprehensive analysis of proliferation effects and metabolic activity of mouse L929 fibroblasts maintained on the surface of developed PLLA‐membranes. The Application of PVP as the pore precursor positively impacted on the surface properties of the constructs. The lack of cytotoxicity of the developed PLLA membranes has been detected.

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“…To obtain the spheres, prodrugs of chlorphe nesin and polylactide (PLACF) (M w = 3400 g/mol, PDI = 1.1), polycapro lactone (PCLCF) (M w = 4400 g/mol, PDI = 1.4), and the block copolymer thereof ( PCLACF) (M w = 4400 g/mol, PDI = 1.2) were used, obtained inhouse by the L-lactide and/or ε-caprolactone ring-opening po lymerization method with zinc 2ethylhexanoate and 5 mol % of the active substance [9]. The active substance, chlorphenesin, 3(4chlorophenoxy)1,2propanediol, was provided by Alfa Aesar, and zinc 2ethylhexanoate was from inhouse production.…”

Section: Methodsmentioning

confidence: 99%

The evaluation of the antimicrobial properties of biodegradable prodrugs with chlorphenesin

et al. 2019

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Spheres of prodrug of polylactide (PLA) or polycaprolactone (PCL) or a copolymer thereof with chlorphenesin (CF) were obtained. Furthermore spheres with an active substance additionally dispersed in the prodrug matrix-hybrid spheres-were prepared. The antimicrobial properties of the prodrug forms obtained were investigated towards bacteria, yeast, and filamentous fungi to verify whether the CF activity of the new formulations maintains. This research shows a wide spectrum of antimicrobiological application, especially when using CF as a preservative.

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Direct Synthesis of Polylactide (PLA)-Chlorphenesin Prodrug and Optimization Thereof with the Aid of DOE

Cited by 14 publications

References 13 publications

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Kinetics of Polycondensation of Sebacic Acid with Glycerol

Design of experiments‐based strategy for development and optimization of polylactide membranes preparation by wet inversion phase method

The evaluation of the antimicrobial properties of biodegradable prodrugs with chlorphenesin

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