Direct Synthesis and Morphological Characterization of Gold-Dendrimer Nanocomposites Prepared Using PAMAM Succinamic Acid Dendrimers: Preliminary Study of the Calcification Potential

Abstract

Gold-dendrimer nanocomposites were obtained for the first time by a simple colloidal approach based on the use of polyamidoamine dendrimers with succinamic acid terminal groups and dodecanediamine core. Spherical and highly crystalline nanoparticles with dimensions between 3 nm and 60 nm, and size-polydispersity depending on the synthesis conditions, have been generated. The influence of the stoichiometric ratio and the structural and architectural features of the dendrimers on the properties of the nanocomposites has been described. The self-assembling behaviour of these materials produces gold-dendrimer nanostructured porous networks with variable density, porosity, and composition. The investigations of the reaction systems, by TEM, at two postsynthesis moments, allowed to preliminary establish the control over the properties of the nanocomposite products. Furthermore, this study allowed better understanding of the mechanism of nanocomposite generation. Impressively, in the early stages of the synthesis, the organization of gold inside the dendrimer molecules has been evidenced by micrographs. Growth and ripening mechanisms further lead to nanoparticles with typical characteristics. The potential of such nanocomposite particles to induce calcification when coating a polymer substrate was also investigated.

Disposable immunoplatforms for the simultaneous determination of biomarkers for neurodegenerative disorders using poly(amidoamine) dendrimer/gold nanoparticle nanocomposite

“…Stabilizers play an important role in the preparation of metal nanoparticles by controlling particle size and providing electrostatic interactions and steric hindrance effects to prevent the nanoparticle aggregation [27,28]. In this sense, poly(amidoamine) (PAMAM) dendrimers have been used to encapsulate and stabilize metal nanoparticles, as well as to provide a large number of functional groups suitable for biomolecule loading [29,30]. Various nanoparticle-PAMAMbased strategies have been exploited for biosensing.…”

Electrochemical Interrogation of G3-Poly(propylene thiophenoimine) Dendritic Star Polymer in Phenanthrene Sensing

“…This changed the electrode surface as well as the transfer rate of electrons, which resulted in the oxidation of PHE on the star-copolymer, showing a better electrocatalytic performance with a higher catalytic performance. It also indicates that the variable multi-functionality and intrinsic architecture of G3PPT dendrimer with internal cages strongly stabilized the dendritic star-copolymer [ 39 ]. Additionally, the high density of catalytically active species at the periphery of the dendritic support is expected to lead to synergistic effects and selectivity of the PHE [ 40 ].…”

Parallel Synthesis of Poly(amino ether)-Templated Plasmonic Nanoparticles for Transgene Delivery

“…Similar observations have been reported, wherein increasing the ratio of tertiary amines to gold-salt resulted in a decrease in time for observable gold nanoparticle synthesis using PAMAM succinamic acid dendrimers. 58 The ability of tertiary amines to engender faster nanoparticle formation kinetics is likely due to two reasons. First, the binding of tertiary amines to metal ions is weaker than that of secondary or primary amines.…”