Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells

Pasceri, Vincenzo; Willerson, James T.; Yeh, Edward T.H.

doi:10.1161/01.cir.102.18.2165

Cited by 1,730 publications

(1,258 citation statements)

References 18 publications

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“…The inflammatory cell types typically found in the atheroma include monocyte-derived macrophages and lymphocytes [18]. Macrophages present in the atherogenous plaque lead to the release of mediators like cytokines and chemokines which in turn increase the plasma concentration of CRP which amplify inflammatory and procoagulant responses [19]. Several other inflammatory markers for prediction of coronary accidents in healthy men and women and in patients with stable angina, acute coronary diseases and in follow up of cardiovascular accident have been studied.…”

Section: Discussionmentioning

confidence: 99%

Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease

Datta¹,

Iqbal²,

Prasad³

2011

Ind J Clin Biochem

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Acute myocardial Infarction is one of the major causes of morbidity & mortality in world and atherosclerosis is the major cause of ischemic heart disease. In order to determine the better clinical marker of atherosclerosis, we estimated serum low-density lipoprotein (LDL-C) and high sensitivity C-reactive protein (hsCRP). Hundred patients of myocardial infarction and 100 controls irrespective of age and sex were studied for these parameters over a period of 2 years. The statistical analysis showed that the serum hsCRP was significantly raised in myocardial infarction cases than controls (P \ 0.01) but LDL-C was not (P [ 0.05). We conclude that the serum hsCRP has better predictive value for risk of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease

Datta¹,

Iqbal²,

Prasad³

2011

Ind J Clin Biochem

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“…Liver is the major producer of CRP, and circulating CRP is an independent risk factor for cardiac events (19). CRP has also been shown to be produced in atherosclerotic lesions (20), and to induce adhesion molecule expression in endothelial cells (21), perhaps playing a direct role in promoting the inflammatory component of atherosclerosis. However in the Dallas Heart Study circulating CRP levels were not directly associated with atherosclerosis extent (22), similar to our own findings in female cynomolgus monkeys (8).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys

Walker¹,

Adams²,

Franke³

et al. 2008

Atherosclerosis

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Male cynomolgus macaques (n=91) consumed an isoflavone (IF)-free, atherogenic control diet containing casein/lactalbumin for five months, then were randomized to three groups: Control (n=30) continued on the control diet; Low IF (n=30) received a mixture of unmodified and IF-depleted soy protein isolate (SPI) (0.94 mg IF/g protein, approximating a human intake of 75 mg/day); and High IF (n=31) received unmodified SPI (1.88 mg IF/g protein, approximating a human intake of 150mg/ day) for 31 months. Iliac and carotid artery atherosclerosis, and arterial and hepatic mRNA transcripts related to inflammation and estrogen receptors (ER) were measured. Trend analysis identified a significant inverse relationship between dietary IF content and plaque area in the iliac (p<0.05) but not carotid arteries (p>0.13). No significant effect of diet on inflammatory gene or estrogen receptor expression was observed. Plaque area was positively correlated with the mRNA transcript levels for arterial MCP-1, ICAM-1, and the macrophage marker CD68 (all r>0.25, p<0.03), and negatively correlated with Erα and ERβ (all r<−0.23, p<0.03). Coronary artery plaque area appeared to be more closely associated with gene expression patterns of the iliac arteries than the carotid arteries. The data suggests benefits of dietary soy on atherosclerotic plaque development in males may be mediated through inflammation-independent pathways. The negative associations of arterial ERα expression with atherosclerosis lend support to a mechanistic role for estrogen receptors in atherosclerosis susceptibility which merits further study.

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“…Inflammation facilitates that infiltrative process and thus would be expected to be associated with the severity of the structural change. 18,19 Nonetheless, inflammation without endothelial dysfunction might not be associated with atherosclerosis, and endothelial dysfunction without inflammation might have a more benign course. Thus the correlations among these markers -inflammation as identified by CRP, endothelial dysfunction as identified by reduced small artery elasticity, 20 and structural changes in the conduit arteries as identified by large artery stiffness -would be expected to be modest.…”

Section: Discussionmentioning

confidence: 99%

Relationship between C-reactive protein and arterial stiffness in an asymptomatic population

et al. 2005

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Plasma concentration of high sensitive C-reactive protein (hsCRP) is used as a marker for inflammatory states and is directly correlated with the risk for coronary heart disease. Evidence concerning the role of inflammation in atheroma formation has been derived from several models of atherosclerosis. Inflammation should exert its adverse vascular effects by structural changes in the artery wall and consequently alterations in arterial elasticity, which could be detected already in asymptomatic early vascular disease. We hypothesized that CRP is related to large artery elasticity, but not to small artery elasticity in early vascular disease. Therefore, we examined the association between arterial stiffness of large and small arteries and inflammation in an asymptomatic population referred for primary prevention cardiovascular screening. Studies were performed in 391 subjects (age 21-82 years; 254 men, 137 women) who underwent screening at the Cardiovascular Disease Prevention Center. Large artery (C1) and small artery (C2) elasticity indices were obtained by the CVProfiler 2000 (HDI, Eagan, MN, USA). After overnight fasting, venous samples were taken for measurement of hsCRP, lipids, glucose. There was a significant inverse correlation between hsCRP (0.2970.40 mg/dl) and C1 (16.775.8 ml/mmHg), r ¼ À0.133, P ¼ 0.01; there was no significant correlation between hsCRP and C2 (6.673.2 ml/mmHg). C2, but not hsCRP, was inversely correlated with age, abnormal lipids and glucose, whereas C1, but not hsCRP, was inversely correlated with age and systolic blood pressure (SBP). In multiple regression analysis, the relationship between hsCRP and C1 was not affected by age, body mass index, SBP, serum glucose or lipids. In conclusion, these findings support the hypothesis that hsCRP, a marker for acute and low-grade inflammation, is associated with large artery but not with small artery elasticity in asymptomatic individuals undergoing primary prevention cardiovascular screening.

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Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells

Cited by 1,730 publications

References 18 publications

Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease

Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease

Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys

Relationship between C-reactive protein and arterial stiffness in an asymptomatic population

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