Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease

Datta, Subinay; Iqbal, Zahidul; Prasad, Kondapalli Siva

doi:10.1007/s12291-010-0100-4

Cited by 17 publications

(14 citation statements)

References 34 publications

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“…Correlation analyses demonstrated that levels of estrogen, hs-CRP and MMP-9 were significantly correlated with the number of stenosed coronary vessels, and there was also a correlation between levels of estrogen, hs-CRP and MMP-9. These results indicate that levels of estrogen, hs-CRP and MMP-9 are associated with the severity of coronary artery lesions and the stability of coronary artery plaques in patients with ACS, which is consistent with previous studies ( 17 – 19 ). Compared with patients with SAP, patients with ACS had a greater number of vulnerable and unstable atherosclerotic plaques in which inflammation was more active.…”

Section: Discussionsupporting

confidence: 93%

Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9

Guo

Zhang

Jun-biao

et al. 2014

Experimental and Therapeutic Medicine

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The aim of this study was to investigate the correlation between the severity of coronary artery lesions in patients with acute coronary syndromes (ACS) and levels of estrogen, high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9). A total of 65 patients with ACS, 33 patients with stable angina pectoris (SAP) and 36 healthy controls were randomly enrolled. Patients with ACS were subdivided into two groups: Acute myocardial infarction (AMI; n=30) and unstable angina pectoris (UAP; n=35). Serum levels of estrogen, hs-CRP and MMP-9 were detected in the four groups of subjects. Serum estrogen levels in patients with AMI, UAP and SAP were significantly lower than those in the control group (P<0.05). Estrogen levels were also significantly different among the AMI, UAP and SAP groups (P<0.05), with a progressive increase across the three respective groups. Compared with healthy subjects, patients with AMI had the highest levels of hs-CRP and MMP-9, followed in descending order by those with UAP and SAP (P<0.05). Levels of hs-CRP and MMP-9 were also significantly different among the AMI, UAP and SAP groups (P<0.05). Serum estrogen levels were negatively correlated with hs-CRP and MMP-9 levels (r=−0.6634 and −0.6878, respectively; both P<0.05). hs-CRP and MMP-9 levels correlated positively (r=0.7208, P<0.05). The number of stenosed coronary vessels was negatively correlated with estrogen levels (r=−0.6467, P<0.05), and positively correlated with hs-CRP and MMP-9 levels (r=0.6519 and 0.6835, respectively; both P<0.05). In conclusion, serum estrogen, hs-CRP and MMP-9 levels were significantly correlated with the severity of coronary artery lesions. There was also a significant correlation between serum estrogen, hs-CRP and MMP-9 levels. These data indicate that serum estrogen, hs-CRP and MMP-9 have the potential to be used as biomarkers for evaluating the severity of coronary artery lesions and the stability of coronary artery plaques.

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Section: Discussionsupporting

confidence: 93%

Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9

Guo

Zhang

Jun-biao

et al. 2014

Experimental and Therapeutic Medicine

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“…Besides obesity, other lifestyle factors contribute toward higher hsCRP such as smoking and gender, with women exhibiting stronger associations between waist circumference and hsCRP than men [34]. Higher levels of hsCRP are also associated with incident myocardial infarctions, emphasizing further the pervasive relation between inflammation and heart disease [36]. …”

Section: Obesity and Systemic Inflammationmentioning

confidence: 99%

Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: A need for screening tools to target interventions

2013

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Cardiovascular disease (CVD) and type 2 diabetes mellitus have their roots in childhood, particularly in obese children and adolescents, raising important opportunities for early lifestyle intervention in at-risk individuals. However, not all obese individuals are at the same risk for disease progression. Accurate screening of obese adolescents may identify those in greatest need for intensive intervention to prevent or delay future disease. One potential screening target is obesity-related inflammation, which contributes to insulin resistance, metabolic syndrome, and CVD. In adults, the inflammatory marker high-sensitivity C-reactive protein (hsCRP) has utility for risk stratification and treatment initiation in individuals of intermediate CVD risk. In adolescents, hsCRP shares many of the associations of hsCRP in adults regarding the degree of insulin resistance, metabolic syndrome, and carotid artery media thickness. However, long-term data linking increased hsCRP levels—and increased insulin or decreased adiponectin—in childhood to adult disease outcomes are lacking at this time. Future efforts continue to be needed to identify childhood clinical and laboratory characteristics that could be used as screening tests to predict adult disease progression. Such tests may have utility in motivating physicians and patients' families toward lifestyle changes, ultimately improving prevention efforts.

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“…High-sensitive C-reactive protein (Hs-CRP), a diagnostic tool for assessment of cardiovascular disease, is a marker of low-grade inflammation, which may lead to atherosclerosis [7]. Estimation of Hs-CRP may be valuable since it is an effective marker for heart diseases rather than low-density lipoprotein (LDL) cholesterol alone [8]. Hs-CRP may evaluate the status of low-grade inflammation in patients with SCH.…”

Section: Introductionmentioning

confidence: 99%

Low-Grade Inflammation in Subclinical Hypothyroidism: Role of Highsensitive C-Reactive Protein

Kumar

Sharma

et al. 2018

Asian J Pharm Clin Res

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Objective: Subclinical hypothyroidism (SCH) patients may present with abnormal lipid profile more specifically in patients having thyroid-stimulating hormone (TSH) >10 mIU/L. Since the contradiction still lies with patients having TSH <10 mIU/L, so the role of high-sensitive C-reactive protein (Hs- CRP) may be important with the prediction of inflammatory cardiovascular risk.Methods: Recently diagnosed 30 SCH patients both male and female were recruited and compared 30 normal healthy adults. Age and body mass index (BMI) of the study population were noted. Thyroid profile including TSH, FT4, and T3 was measured by an enzyme-linked immunosorbent assay (ELISA). Total cholesterol, triglycerides, and high-density lipoprotein (HDL) cholesterol were measured by the CHOD-POD method, GPO-PAP method, and CHOD-POD/phosphotungstic method. Low-density lipoprotein (LDL) cholesterol and very low-density cholesterol were measured by Friedewald formula. Lipoprotein ratios were also calculated. An ELISA was also used for the estimation of Hs-CRP.Results: The significant results were obtained in this study. BMI was significantly (<0.01) elevated in patients’ group compared to the control group. In the thyroid profile, TSH was significantly (<0.05) different between the groups. Total cholesterol, triglycerides, and LDL-cholesterol were significantly (<0.01) elevated in the case group. A significantly lower concentration of HDL cholesterol was observed in SCH patients when compared with control subjects. There was an elevated concentration of lipoprotein ratios in patients group. The mean concentration of Hs-CRP was highly significant between the groups. The level was higher in the case group compared to the control group. In patients’ group, there was a positive association (β- 0.36) (confidence interval 95%–0.002–0.536) between TSH and Hs-CRP. This association was highly significant.Conclusion: SCH patients having TSH <10 μIU/ml were characterized by dyslipidemia and elevated Hs-CRP. Increased lipoprotein ratios and Hs-CRP may promote low-grade inflammation in SCH patients, by which cardiovascular risk can be developed.

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Comparison Between Serum hsCRP and LDL Cholesterol for Search of a Better Predictor for Ischemic Heart Disease

Cited by 17 publications

References 34 publications

Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9

Correlation between the severity of coronary artery lesions and levels of estrogen, hs-CRP and MMP-9

Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: A need for screening tools to target interventions

Low-Grade Inflammation in Subclinical Hypothyroidism: Role of Highsensitive C-Reactive Protein

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