Direct Inhibitory Effect of Fluoxetine on N-Methyl-D-Aspartate Receptors in the Central Nervous System

Antidepressant-like and neuroprotective effects of Aloysia gratissima: Investigation of involvement of l-arginine-nitric oxide-cyclic guanosine monophosphate pathway

“…The dose of MK-801 used in the present study was previously shown to cause no effect in the open-field test, but it was able to cause a synergistic antidepressant-like effect with folic acid in the FST (Brocardo et al, 2008). Moreover, it has been shown that fluoxetine and desipramine inhibit NMDA receptors at clinically relevant concentration range (Szasz et al, 2007), a finding that indicates that glutamatergic, noradrenergic and serotonergic systems interact in the mechanism of action of antidepressants (Forray et al, 1999;Maura et al, 2000;Bonanno et al, 2005;Szasz et al, 2007). In addition, it was recently reported that the antidepressant-like effect of escitalopram in the FST was reversed by NMDA pretreatment in mice (Zomkowski et al, 2010).…”

Evidence for the involvement of NMDA receptors in the antidepressant-like effect of nicotine in mouse forced swimming and tail suspension tests

“…Recently, discovery of the rapid antidepressant effect of NMDA receptors antagonists has linked the glutamatergic system to the pathophysiology of depression (Manji et al 2001) and the mechanism of action of some antidepressants (Berman et al 2000;Szasz et al 2007). Antidepressant-like effects of acute NMDA receptor antagonist treatment in rodents have been observed in many models of depression, including inescapable stress (Trullas and Skolnick 1990), learned helplessness (Autry et al 2011), the tail suspension test (Mantovani et al 2003a), and the forced swimming test (Autry et al 2011;Maj et al 1992;Yildiz et al 2000).…”

Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review

“…Unfortunately, little information is available regarding neurotransmitter substrates that are critical for the behavioral effects of different types of drugs in animal models. In addition, data accumulated in the last decade indicate that NMDA receptors may be involved in the pathophysiology of depression and the mechanism of action of antidepressants (Szasz et al, 2007). These data suggest that the inhibitory effect of fluoxetine is exerted directly on NMDA receptors, contributing to the therapeutic effects of this drug.…”