Direct Extraction of Lutein from Wet Macroalgae by Liquefied Dimethyl Ether without Any Pretreatment

Kanda, Hideki; Diono, Wahyu; Machmudah, Siti; Goto, Motonobu

doi:10.1021/acsomega.0c03358

Cited by 24 publications

(11 citation statements)

References 31 publications

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“…Himanthalia elongata Fuco 18.6 (DW) [99] Hypnea musciformis β-car, lut, zea 0.0029 (TCs, FW) [100] Monostroma nitidum Lut 0.3 (FW) [101] Sargassum muticum Fuco 0.0084 (TCs, DW) [102] Abbreviations: DW: dry weight, FW: fresh weight, β-car: β-carotene, fuco: fucoxanthin lut: lutein, TCs: total carotenoids content, zea: zeaxanthin.…”

Section: Speciesmentioning

confidence: 99%

Carotenoids as Natural Colorful Additives for the Food Industry

Lourenço-Lopes¹,

Carreira-Casais²,

Fraga-Corral³

et al. 2022

Natural Food Additives

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The application of natural colorants is increasing in the food industry because they are considered safer and healthier than some synthetic pigments. Natural colorants can improve the organoleptic properties of foodstuffs, provide additional benefits such as enhance their nutritional value and/or extend shelf-life. Plants, fungi, bacteria or algae naturally produce different natural colorants, including carotenoids. These compounds are classified into two main groups: pure hydrocarbon carotenes (α- and β-carotenes, lycopene) and oxygenated derivatives of xanthophylls (lutein, zeaxanthin, astaxanthin, fucoxanthin, cryptoxanthin, etc.). Carotenoids have been related with beneficial properties like antioxidant, antidiabetic, antitumor or antimicrobial, so they are a natural and healthy alternative to the use of synthetic colorants. Thus, it is critical to optimize their extraction, by utilizing novel and green techniques, and their stability through encapsulation processes. This chapter aims to review natural sources of carotenoids, strategies to efficiently extract and produce them and their potential application as food colorants.

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Section: Speciesmentioning

confidence: 99%

Carotenoids as Natural Colorful Additives for the Food Industry

Lourenço-Lopes¹,

Carreira-Casais²,

Fraga-Corral³

et al. 2022

Natural Food Additives

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“…After approximately 5 days, the macroalgae samples were incubated in an oven (Binder ED 56) at 40 • C until reaching a constant weight [29]. Dried samples were then ground with a blade grain miller (food-grade stainless steel) and kept in powder form at 4 • C until further use [30].…”

Section: Macroalgal Materialsmentioning

confidence: 99%

The Antiproliferative and Apoptosis-Inducing Effects of the Red Macroalgae Gelidium latifolium Extract against Melanoma Cells

et al. 2021

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The red macroalga Gelidium latifolium is widely distributed in the coastal areas of Indonesia. However, current knowledge on its potential biological activities is still limited. In this study, we investigated the potential bioactive compounds in Gelidium latifolium ethanol extract (GLE), and its cytotoxic effects against the murine B16-F10 melanoma cell line. GLE shows high total phenolic content (107.06 ± 17.42 mg GAE/g) and total flavonoid content (151.77 ± 3.45 mg QE/g), which potentially contribute to its potential antioxidant activity (DPPH = 650.42 ± 2.01 µg/mL; ABTS = 557.01 ± 1.94 µg/mL). ESI-HR-TOF-MS analysis revealed large absorption in the [M-H]- of 327.2339 m/z, corresponding to the monoisotopic molecular mass of brassicolene. The presence of this compound potentially contributes to GLE’s cytotoxic activity (IC50 = 84.29 ± 1.93 µg/mL). Furthermore, GLE significantly increased the number of apoptotic cells (66.83 ± 3.06%) compared to controls (18.83 ± 3.76%). Apoptosis was also confirmed by changes in the expression levels of apoptosis-related genes (i.e., p53, Bax, Bak, and Bcl2). Downregulated expression of Bcl2 indicates an intrinsic apoptotic pathway. Current results suggest that components of Gelidium latifolium should be further investigated as possible sources of novel antitumor drugs.

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“…Note that DME is not diethyl ether, which is commonly known as ether. DME is the simplest form of ether, with characteristics that include a low normal boiling point (−24.8 • C) [5]; therefore, DME is liquefied when it is used as an extraction solvent [6][7][8][9][10]. There is no residual DME in the extracted materials at normal temperatures after extraction [8,9].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Lipid Extraction from Soya Bean by Addition of Dimethyl Ether as Entrainer into Supercritical Carbon Dioxide

Kanda

Fukuta

Diono

et al. 2021

Foods

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Soya beans contain a variety of lipids, and it is important to selectively separate neutral lipids from other lipids. Supercritical carbon dioxide extraction has been used as an alternative to the selective separation of neutral lipids from soya beans, usually using non-polar hexane. However, supercritical carbon dioxide extraction has a high operating pressure of over 40 MPa. On the other hand, liquefied dimethyl ether extraction, which has attracted attention in recent years, requires an operating pressure of only 0.5 MPa, but there is concern about the possibility of an explosion during operation because it is a flammable liquefied gas. Therefore, this study aims to reduce the operating pressure by using a non-flammable solvent, supercritical carbon dioxide extraction mixed with liquefied dimethyl ether as an entrainer. The extraction rate and the amount of neutral lipids extracted increased with increasing amounts of added liquefied dimethyl ether. In the mixed solvent, the amount of neutral lipids extracted was higher at an operating pressure of 20 MPa than in pure supercritical carbon dioxide extraction at 40 MPa. The mixing of liquefied dimethyl ether with supercritical carbon dioxide allowed an improvement in the extraction of neutral lipids while remaining non-flammable.

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Direct Extraction of Lutein from Wet Macroalgae by Liquefied Dimethyl Ether without Any Pretreatment

Cited by 24 publications

References 31 publications

Carotenoids as Natural Colorful Additives for the Food Industry

Carotenoids as Natural Colorful Additives for the Food Industry

The Antiproliferative and Apoptosis-Inducing Effects of the Red Macroalgae Gelidium latifolium Extract against Melanoma Cells

Enhancement of Lipid Extraction from Soya Bean by Addition of Dimethyl Ether as Entrainer into Supercritical Carbon Dioxide

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