Direct evidence of intra- and interhemispheric corticomotor network degeneration in amyotrophic lateral sclerosis: An automated MRI structural connectivity study

Rose, Stephen; Pannek, Kerstin; Bell, Christopher J.; Baumann, Fusun; Hutchinson, Nicole; Coulthard, Alan; McCombe, Pamela A.; Henderson, Robert D.

doi:10.1016/j.neuroimage.2011.08.054

Cited by 65 publications

(63 citation statements)

References 58 publications

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“…58,59 Findings in ALS populations have been more consistent in terms of structural connectivity disruption. There is extensive evidence of reduced FA in the CST and corresponding motor network, [60][61][62][63][64][65][66][67][68] and of an association between sensorimotor network damage and disease severity. 63,[66][67][68] Consistent with these data are the findings from two studies investigating ALS patients carrying super oxide dismutase 1 mutations, a dominantly inherited form of ALS associated with a less-severe clinical course and longer survival.…”

Section: Behavioural Variant Frontotemporal Dementiamentioning

confidence: 99%

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

et al. 2014

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Functional and structural connectivity measures, as assessed by means of functional and diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) and other disorders. This Review aims to summarize current evidence that connectivity biomarkers are associated with upstream and downstream disease processes (molecular pathology and clinical symptoms, respectively) in the major neurodegenerative diseases. The vast majority of studies have addressed functional and structural connectivity correlates of clinical phenotypes, confirming the predictable correlation with topography and disease severity in AD and frontotemporal dementia. In neurodegenerative diseases with motor symptoms, structural--but, to date, not functional--connectivity has been consistently found to be associated with clinical phenotype and disease severity. In the latest studies, the focus has moved towards the investigation of connectivity correlates of molecular pathology. Studies in cognitively healthy individuals with brain amyloidosis or genetic risk factors for AD have shown functional connectivity abnormalities in preclinical disease stages that are reminiscent of abnormalities observed in symptomatic AD. This shift in approach is promising, and may aid identification of early disease markers, establish a paradigm for other neurodegenerative disorders, shed light on the molecular neurobiology of connectivity disruption and, ultimately, clarify the pathophysiology of neurodegenerative diseases.

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Section: Behavioural Variant Frontotemporal Dementiamentioning

confidence: 99%

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

et al. 2014

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“…Recently, insights into corticomotor connectivity changes in ALS have been derived by acquiring high angular resolution diffusion imaging (HARDI) scans along with high-resolution structural images (sMRI), confi rming and magnifying previous DTI results (23). As an alternative DW-MRI approach, the HARDI technique allows to overcome DTI limitations in the analysis of crossing fi bres (24).…”

Section: Original Articlementioning

confidence: 99%

Motor and extramotor neurodegeneration in amyotrophic lateral sclerosis: A 3T high angular resolution diffusion imaging (HARDI) study

Trojsi¹,

Corbo²,

Caiazzo³

et al. 2013

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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In amyotrophic lateral sclerosis (ALS), diffusion weighted magnetic resonance imaging (DW-MRI) has produced mounting evidence of a widespread white matter (WM) damage within motor and extramotor pathways. To provide novel information about the degenerative process in ALS, overcoming some of the limitations imposed by diffusion tensor imaging (DTI), we performed a high angular resolution diffusion imaging (HARDI) analysis of DW-MRI data. Generalized fractional anisotropy (GFA) was evaluated in 19 patients with ALS and 19 matched control subjects, and was correlated with clinical scores of disability, pyramidal impairment by upper motor neuron (UMN) score and frontal dysfunction by the Frontal Systems Behaviour (FrSBe) scale. Results demonstrated that ALS patients showed a significant decrease of GFA in the WM tracts underneath the left and right precentral gyri and the body of the corpus callosum (p < 0.05, corrected), where GFA was significantly related to UMN scores (p < 0.001, uncorrected); and in the left superior longitudinal fasciculus (p < 0.05, corrected), where GFA was significantly related to FrSBe scale scores (p < 0.01, uncorrected). In conclusion, this study revealed a pattern of motor and extramotor frontal diffusivity abnormalities (probably related to behavioural and cognitive dysfunctions) showing a spatial distribution similar to what was previously described in ALS - frontotemporal dementia continuum.

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“…21 In brief, raw diffusion-weighted images were corrected for subject motion by using the method described by Bai and Alexander. 22 Thus, the diffusion tensor was calculated from the (uncorrected) diffusion data.…”

Section: Diffusion Processingmentioning

confidence: 99%

Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [¹⁸F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?

Rose

Fay²,

Thomas³

et al. 2012

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:There is significant interest in whether diffusion-weighted MR imaging indices, such as the minimum apparent diffusion coefficient, may be useful clinically for preoperative tumor grading and treatment planning. To help establish the pathologic correlate of minimum ADC, we undertook a study investigating the relationship between minimum ADC and maximum FDOPA PET uptake in patients with newly diagnosed glioblastoma multiforme.

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Direct evidence of intra- and interhemispheric corticomotor network degeneration in amyotrophic lateral sclerosis: An automated MRI structural connectivity study

Cited by 65 publications

References 58 publications

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

Motor and extramotor neurodegeneration in amyotrophic lateral sclerosis: A 3T high angular resolution diffusion imaging (HARDI) study

Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [¹⁸F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?

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Direct evidence of intra- and interhemispheric corticomotor network degeneration in amyotrophic lateral sclerosis: An automated MRI structural connectivity study

Cited by 65 publications

References 58 publications

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy

Motor and extramotor neurodegeneration in amyotrophic lateral sclerosis: A 3T high angular resolution diffusion imaging (HARDI) study

Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [18F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?

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Correlation of MRI-Derived Apparent Diffusion Coefficients in Newly Diagnosed Gliomas with [¹⁸F]-Fluoro-L-Dopa PET: What Are We Really Measuring with Minimum ADC?