Direct enantioseparation of lipoic acid in dietary supplements by capillary electrophoresis using trimethyl‐β‐cyclodextrin as a chiral selector

Kodama, Shuji; Taga, Atsushi; Aizawa, Sen-ich; Kemmei, Tomoko; Honda, Yoshitaka; Suzuki, Kentaro; Yamamoto, Atsushi

doi:10.1002/elps.201100531

Cited by 27 publications

(11 citation statements)

References 35 publications

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“…A variety of natural product compounds that exhibit chirality have been studied using CE techniques . Chirality is also of major importance in the biological activity of compounds, and thus, Kodama et al studied the content of the naturally occurring antioxidant (R)‐lipoic acid in food supplements. The use of a sulfonated capillary and trimethyl‐β‐cyclodextrin as chiral selector were the key features of the developed chiral CE‐UV method.…”

Section: Chiral Analysis Of Food Compoundsmentioning

confidence: 99%

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

et al. 2013

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In this work, the analysis of foods and food components using capillary electromigration methods is reviewed. The present work presents and discusses the main CE applications performed in Food Science and Technology including the new field of Foodomics, reviewing recent results on food quality and safety, nutritional value, storage, bioactivity, as well as applications of CE for monitoring food interactions and food processing. The CE analysis of a large variety of food-related molecules with different chemical properties, including amino acids, peptides, proteins, phenolic compounds, carbohydrates, DNA fragments, vitamins, toxins, pesticides, additives, and other minor compounds is described. The use of microchips, CE-MS, and chiral-CE in food analysis is also discussed as well as other current and foreseen trends in this area of research. Following the previous review by Castro-Puyana et al. (Electrophoresis, 2012, 33, 147–167), the current review covers the papers that were published from February 2011 to February 2013.

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Section: Chiral Analysis Of Food Compoundsmentioning

confidence: 99%

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

et al. 2013

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“…Being natural products, only R‐lipoic acid should be present, however, the analysis of nine samples revealed the presence of the racemic acid arising from the synthetic process. The two enantiomers were separated by CZE, adding to the background‐electrolyte (BGE) two‐cyclodextrin (CD) derivatives . Among other applications in food chemistry, it is worth mentioning the analysis of chiral α‐amino acids (AA), fungicides, herbicides and other pesticides, and phenols described in a review paper by Herrero et al …”

Section: Selected Applications Related To Chiral Separationmentioning

confidence: 99%

Chiral Separations using Miniaturized Techniques: State of the Art and Perspectives

Fanali

2016

Israel Journal of Chemistry

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The separation and analysis of chiral compounds is an important topic of research, because these analytes are involved in various processes, e.g., biological, pharmacological, human health, etc. Their separation has also been recently obtained utilizing microfluidic techniques, such as capillary electrophoresis (CE), electrochromatography (CEC), and capillary/nano‐liquid chromatography (CLC/nano‐LC). Enantiomeric separation is mainly obtained by applying the direct resolution method, where a chiral selector (CS) is present in the separation system, either added to the mobile phase (MP) or bonded to the stationary phase or to the capillary wall. Among the several CSs used in microfluidic techniques, cyclodextrins, proteins, peptides, glycopeptide antibiotics, and modified polysaccharides are the most employed. Microfluidic techniques can offer several advantages over conventional analytical tools, e.g., high efficiency, high mass sensitivity, and reduced volumes of MP and sample. Optimized methods have been applied in different fields, such as biomedical, food chemistry, environment, pharmaceutical, etc. Excellent results have been achieved in CE and nano‐LC. Although CEC can offer higher efficiency due to the use of a strong electroosmotic flow, its use is less popular than the other. This limitation can be explained with the limited number of the stationary phases (SPs) commercially available.

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“…During the reviewed period of time, several reports were published about the application of CE for the determination of enantiomeric purity and/or single active enantiomers in bulk drugs and/or final drug formulations including levocetirizine , ( R )‐modafinil , (–)‐huperzine A , ( R )‐pramipexol , ( R )‐(–)‐chloroquine , RS 86017 , L ‐methotrexate , ( S )‐pantoprazole , and escitalopram . The content of the lipoic acid enantiomers was determined in dietary supplements . Experimental details of these studies are summarized in Table .…”

Section: Recent Applications Of Ce Enantioseparationsmentioning

confidence: 99%

Recent advances in electrodriven enantioseparations

Jáč

Scriba

2012

J of Separation Science

109

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Capillary electromigration techniques have developed into significant analytical separation tools especially for enantioseparations. While CE can be considered a mature technique as documented by its wide applications, CEC is still in a developmental state despite many research efforts. The success of stereospecific CE separation methods is due to the high specificity and flexibility of the technique as well as the availability of many types of chiral selectors. Thus, numerous methods have been developed for the analysis of chiral compounds in chemical, biochemical, pharmaceutical, environmental, and forensic sciences. However, most reported applications deal with pharmaceuticals. The search for new chiral selectors also continued despite the fact that most applications were performed using cyclodextrins. Furthermore, CE has been combined with spectroscopic and molecular modeling studies in attempts to understand the interactions between chiral selectors and analytes. The present review focuses on recent examples of mechanistic aspects of capillary enantioseparations with regard to mathematical modeling of enantioseparations, investigations of the analyte-complex structures as well as new chiral selectors and applications of chiral analyses by CE and CEC. It covers the literature published between January 2011 and August 2012.

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Direct enantioseparation of lipoic acid in dietary supplements by capillary electrophoresis using trimethyl‐β‐cyclodextrin as a chiral selector

Cited by 27 publications

References 35 publications

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

Recent advances in the application of capillary electromigration methods for food analysis and Foodomics

Chiral Separations using Miniaturized Techniques: State of the Art and Perspectives

Recent advances in electrodriven enantioseparations

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