Direct electron transfer between PQQ dependent glucose dehydrogenases and carbon electrodes: An approach for electrochemical biosensors

Razumienė, Julija; Vilkanauskyte, Aiste; Gureviciene, Vidute; Barkauskas, Jurgis; Meškys, Rolandas; Laurinavičius, Valdas

doi:10.1016/j.electacta.2006.03.058

Cited by 53 publications

(37 citation statements)

References 32 publications

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“…In paper III, PQQ-GDh was used as anodic enzyme for glucose oxidation and DET was achieved between the enzyme and the surface of the electrode, corroborating previous reports Razumiene et al, 2006;Zayats et al, 2005).…”

Section: Pyrroloquinoline Quinone-glucose Dehydrogenasesupporting

confidence: 69%

Flexible and transparent biological electric power sources based on nanostructured electrodes

Arribas¹

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Section: Pyrroloquinoline Quinone-glucose Dehydrogenasesupporting

confidence: 69%

Flexible and transparent biological electric power sources based on nanostructured electrodes

Arribas¹

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“…Activating stage 8 and combining the parts dealing with (a) the matrix suitable for direct electron transfer (DET) (Razumiene et al, 2006), (b) the optimum electrode surface that fits DET (Lee et al, 2006), and (c) the novel method for construction of this electrode, a simulated case has been presently constructed (Lim et al, 2005) involving the use of a purroloquinoline quinone (PQQ)-dependent glucose dehydrogenase on carbon nanotubes for direct electron transfer.…”

Section: Case Studymentioning

confidence: 99%

Innovation in biotechnology: moving from academic research to product development—the case of biosensors

Siontorou

Batzias

2010

Critical Reviews in Biotechnology

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The fast pace of technological change in the biotechnology industry and the market demands require continuous innovation, which, owing to the science base of the sector, derives from academic research through a transformation process that converts science-oriented knowledge to marketable products. There appear to be some inherent difficulties in transforming directly the knowledge output of academic research to industrial use. The purpose of this article is to examine certain transition mechanisms from monodisciplinary academic isolation (curiosity-driven and internal-worth innovation) to university-industry alliances (market-driven and public-worth innovation) through inter-organizational multidisciplinary collaboration and contextualize the analysis with the case of biosensors. While the majority of literature on the subject studies the channels of knowledge transfer as determinants of alliance success (transferor/transferee interactions), either from the university side (science base) or the industry side (market base), this article focuses on the transferable (technology base) and how it can be strategically modeled and managed by the industry to promote innovation. Based on the valuable lessons learnt from the biosensor paradigm, the authors argue that strategic industry choices deal primarily with the best stage/point to intersect and seize the university output, implanting the required element of marketability that will transform an idea to a viable application. The authors present a methodological approach for accelerating the knowledge transfer from the university to industry aiming at the effective transition of science to products through a business model reconfiguration.

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“…We consider that the following chemical reactions take place during the operation of the biosensor [15,28,32,33]:

{GDH}_{ox} + glucose \overset{k_{1}}{true\to} {GDH}_{red} + gluconolactone

{GDH}_{red} {+ PMS}_{ox} \overset{k_{2}}{true\to} {GDH}_{ox} {+ PMS}_{red}

{PMS}_{red} + O_{2} \overset{k_{3}}{true\to} {PMS}_{ox} {+ HO}_{2}^{-}

{PMS}_{red} \to {PMS}_{ox} {+ 2 e}^{-}

…”

Section: Mathematical Modelmentioning

confidence: 99%

Computational Modeling of Mediator Oxidation by Oxygen in an Amperometric Glucose Biosensor

Šimelevičius

Petrauskas

Baronas

et al. 2014

Sensors

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In this paper, an amperometric glucose biosensor is modeled numerically. The model is based on non-stationary reaction-diffusion type equations. The model consists of four layers. An enzyme layer lies directly on a working electrode surface. The enzyme layer is attached to an electrode by a polyvinyl alcohol (PVA) coated terylene membrane. This membrane is modeled as a PVA layer and a terylene layer, which have different diffusivities. The fourth layer of the model is the diffusion layer, which is modeled using the Nernst approach. The system of partial differential equations is solved numerically using the finite difference technique. The operation of the biosensor was analyzed computationally with special emphasis on the biosensor response sensitivity to oxygen when the experiment was carried out in aerobic conditions. Particularly, numerical experiments show that the overall biosensor response sensitivity to oxygen is insignificant. The simulation results qualitatively explain and confirm the experimentally observed biosensor behavior.

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Direct electron transfer between PQQ dependent glucose dehydrogenases and carbon electrodes: An approach for electrochemical biosensors

Cited by 53 publications

References 32 publications

Flexible and transparent biological electric power sources based on nanostructured electrodes

Flexible and transparent biological electric power sources based on nanostructured electrodes

Innovation in biotechnology: moving from academic research to product development—the case of biosensors

Computational Modeling of Mediator Oxidation by Oxygen in an Amperometric Glucose Biosensor

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