Photoreduetion of NAD has been accomplished by a system consi~tin~ of the NAD-depeadent h:cdrogenase from Alcaligenes eutrophus immobilized on CdS particles with formate as artificial electron donor. Enzymatieally active NADH is formed under illumination of this system by visible light. Accumulation of the eoenzyme dimer (NAD), was not detected. NAD photoreduction is supposed to proceed via the direct electron tranffgr from the semiconductor to the enz),me electron transport ehaila. However, NADH formation as a result of hydro8enase interaction with anion.radicals (CO'.,-) formed in the course of formate photooxidation cannot at pre.~ent be excluded.