Direct determination of phosphate in urine by sequential-injection analysis with single on-line dilution–calibration method and photometric detection

Themelis, Demetrius G.; Economou, Anastasios; Tsiomlektsis, A.; Tzanavaras, Paraskevas D.

doi:10.1016/j.ab.2004.04.005

Cited by 17 publications

(4 citation statements)

References 19 publications

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“…The mass of 234.81 u corresponds relatively well with the mass of 139 LaHPO 4 1 (234.89 u). In a study by Themelis et al, 13 the concentration of phosphate in urine varied between 0.9 and 1.5 g l À1 , which is in accordance with the concentrations used in this study. According to Minoia et al, 14 the concentration of La in urine can be expected to vary between 0.015 and 3.6 mg l À1 .…”

Section: Interference Pattern From Various Lanthanidessupporting

confidence: 90%

Lanthanide phosphate interferences in actinide determination using inductively coupled plasma mass spectrometry

Nygren

Ramebäck

Baxter³

et al. 2005

J. Anal. At. Spectrom.

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Section: Interference Pattern From Various Lanthanidessupporting

confidence: 90%

Lanthanide phosphate interferences in actinide determination using inductively coupled plasma mass spectrometry

Nygren

Ramebäck

Baxter³

et al. 2005

J. Anal. At. Spectrom.

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“…SIA methods have recognised merits of robustness and versatility enabling the possibility to change the determination conditions without physical reconfiguration of the manifolds. In this scenario, several SIA methods have been reported for the spectrophotometric determination of phosphate [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] as listed in Table 1. However, these methods were generally developed for the application to a single type of water (even when other samples were also used).…”

Section: Introductionmentioning

confidence: 99%

Development of a flow method for the determination of phosphate in estuarine and freshwaters—Comparison of flow cells in spectrophotometric sequential injection analysis

Mesquita¹,

Ferreira²,

Tóth³

et al. 2011

Analytica Chimica Acta

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A sequential injection system with dual analytical line was developed and applied in the comparison of two different detection systems viz; a conventional spectrophotometer with a commercial flow cell, and a multi-reflective flow cell coupled with a photometric detector under the same experimental conditions. The study was based on the spectrophotometric determination of phosphate using the molybdenum-blue chemistry. The two alternative flow cells were compared in terms of their response to variation of sample salinity, susceptibility to interferences and to refractive index changes. The developed method was applied to the determination of phosphate in natural waters (estuarine, river, well and ground waters). The achieved detection limit (0.007 μM PO(4)(3-)) is consistent with the requirement of the target water samples, and a wide quantification range (0.024-9.5 μM) was achieved using both detection systems.

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“…Automation of sample dilution using sequential injection analysis (SI) offers significant possibilities and advantages over batch or previously applied on-line dilution protocols. On-line dilution can be carried out by zone sampling in a practically single-channelled operation mode [9], without reconfigura-tion of the manifolds by adding extra dilution lines [10], dialysis units [11] or mixing chambers [12].…”

Section: Introductionmentioning

confidence: 99%

Automated zone‐sampling dilution by coupling sequential injection analysis to high‐throughput HPLC for the direct determination of gemfibrozil

Tzanavaras

Themelis

Rigas³

2009

J of Separation Science

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A novel automated analytical scheme for the rapid determination of gemfibrozil in drug dissolution samples is reported. The procedure is based on direct coupling of a low pressure continuous flow technique such as sequential injection analysis (SI) to HPLC. SI performs automated dilution of the samples based on zone sampling and fills on-line the loop of the high pressure injection valve. Rapid separation of the analyte from the samples' matrix can be achieved in less than 1.0 min, by using a short RP monolithic column (25x4.6 mm id) at a flow rate of 2 mL/min. The SI and HPLC parts of the setup operate independently: during HPLC separation the next sample is treated by SI. This way a maximum throughput of 60 samples per hour is achieved allowing the complete analysis of a batch of six dissolution samples within 12-18 min based on the replicates. The proposed method was validated in terms of linearity, LOD and LOQ, precision, selectivity and accuracy. Its applicability was tested during quality control of four validation batches of a gemfibrozil-containing formulation. The results were in good agreement with the HPLC method proposed by the US Pharmacopeia.

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Direct determination of phosphate in urine by sequential-injection analysis with single on-line dilution–calibration method and photometric detection

Cited by 17 publications

References 19 publications

Lanthanide phosphate interferences in actinide determination using inductively coupled plasma mass spectrometry

Lanthanide phosphate interferences in actinide determination using inductively coupled plasma mass spectrometry

Development of a flow method for the determination of phosphate in estuarine and freshwaters—Comparison of flow cells in spectrophotometric sequential injection analysis

Automated zone‐sampling dilution by coupling sequential injection analysis to high‐throughput HPLC for the direct determination of gemfibrozil

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