Direct detection of tryptophan for rapid diagnosis of cancer cell metastasis competence by an ultra-sensitive and highly selective electrochemical biosensor

Majidi, Mir Reza; Karami, Pari; Johari-Ahar, Mohammad; Omidi, Yadollah

doi:10.1039/c6ay02103d

Cited by 26 publications

(8 citation statements)

References 43 publications

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“…The signal response was Trp concentration-dependent in the ranges of 0.0001 to 10 and 10 to 300 mM, with an LOD of 64 pM. Furthermore, the aptasensor detected Trp in biological matrices such as human blood serum, saliva, and urine, whose values were in agreement with those from the HPLC method [183].…”

Section: Electrochemical Biosensing Of Crc-associated Cellssupporting

confidence: 65%

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

et al. 2020

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The accurate determination of specific tumor markers associated with cancer with non-invasive or minimally invasive procedures is the most promising approach to improve the long-term survival of cancer patients and fight against the high incidence and mortality of this disease. Quantification of biomarkers at different stages of the disease can lead to an appropriate and instantaneous therapeutic action. In this context, the determination of biomarkers by electrochemical biosensors is at the forefront of cancer diagnosis research because of their unique features such as their versatility, fast response, accurate quantification, and amenability for multiplexing and miniaturization. In this review, after briefly discussing the relevant aspects and current challenges in the determination of colorectal tumor markers, it will critically summarize the development of electrochemical biosensors to date to this aim, highlighting the enormous potential of these devices to be incorporated into the clinical practice. Finally, it will focus on the remaining challenges and opportunities to bring electrochemical biosensors to the point-of-care testing.

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Section: Electrochemical Biosensing Of Crc-associated Cellssupporting

confidence: 65%

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

et al. 2020

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“…A decrease in the interfacial resistance isobserved at the AB/GCE and Au/AB/GCE, suggesting that AB and Au were excellent lectronic conducting materials and can accelerate the electron transfer. [16] The modification process also demonstrated narrow PWs which decreased from 2.67 V for GCE to 2.54 V for AB/GCE and 1.97 V for Au/AB/GCE, respectively (Figure 2b). The PW data suggested that AuNPs decoration accelarated the electron transfer, which matched our previous design.…”

Section: Characterization Of Au/ab/gcementioning

confidence: 95%

Simultaneous Detection of Catechol and Hydroquinone Using Acetylene Black and Gold Nanoparticle Composite Modified Electrodes

Zhu

Wang

et al. 2022

ChemistrySelect

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Quantitative analysis of dihydroxybenzene isomers holds great significance to agricultural chemistry, food safety and environmental protection. In this work, we demonstrate a facile strategy to determine catechol and hydroquinone by using acetylene black and gold nanoparticle composite modified electrodes (Au/AB/GCE). Compared with bare glassy carbon electrode (GCE), Au/AB/GCE showed much better performance in electrocatalytic oxidation-reduction of catechol and hydroquinone. The linear correlation between the peak currents and analyte concentrations suggested the simultaneous detection with ultralow limits of detection (0.5 μM and 1 μM for catechol and hydroquinone, respectively). Besides, the determination is selective and out of interference of common inorganic ions and organic compounds. Anson equation was employed to make a reasonable hypothesis, that the increased surface area and electrical conductivity of Au/AB/GCE contributed these good results. This strategy may become a promising means for ratiometric and simultaneous detection of catechol and hydroquinone in water with convenience and high sensitivity.

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“…In addition, extensive efforts have been made to use the drop-casting method to deposit nanomaterials onto a desired electrode surface for sensing applications that include H2O2 [136][137][138][139][140][141][142][143], dopamine [144][145][146][147][148][149][150][151], uric acid [148][149][150][151][152][153][154][155][156][157][158], ascorbic acid [151,[158][159][160], epinephrine [154], L-glutamic acid [155], urea [70, 161,162], HIV gene detection [163], tryptophan [164], cholesterol [165], miRNA [166,167], cysteine [168], estriol [169], ractopamine [170], lactate [171], and ochratoxin A [172]. Several research groups have reviewed nanomaterial-based nonenzymatic and enzymatic biosen...…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Deposition of nanomaterials: A crucial step in biosensor fabrication

Ahmad

Wolfbeis

Hahn

et al. 2018

Materials Today Communications

154

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 An easy, stable, and reproducible nanomaterial deposition/growth method is crucial for the realization of fabricated biosensor devices' performance, such as device stability, and reproducibility, as well as other sensing properties.  Key challenges for optimum deposition include stability, reproducibility, repeatability, and the ability of deposited nanomaterials to address these challenges is critiqued.

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Direct detection of tryptophan for rapid diagnosis of cancer cell metastasis competence by an ultra-sensitive and highly selective electrochemical biosensor

Abstract: The detection of l-tryptophan (Trp) in the extracellular matrix (ECM) of solid tumors is important, particularly in metastatic tumors, which catabolize Trp to kynurenine to escape from host immune system-mediated recognition.

Cited by 26 publications

References 43 publications

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers

Simultaneous Detection of Catechol and Hydroquinone Using Acetylene Black and Gold Nanoparticle Composite Modified Electrodes

Deposition of nanomaterials: A crucial step in biosensor fabrication

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