Direct coupling of packed column supercritical fluid chromatography to continuous corona discharge ion mobility spectrometry

Rahmanian, Ahmad; Ghaziaskar, Hassan S.; Khayamian, Taghi

doi:10.1016/j.chroma.2012.11.063

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…The main advantages of IMS instruments are their high sensitivity, small size, and operation at atmospheric pressure, which make IMS widely applied in many elds, such as drugs and explosives detection, 9,10 environment pollution monitoring, 11,12 disease diagnosis, 13,14 structure analysis of clusters 15,16 and biomolecular research. 17,18 Most studies of IMS focus on different ionization sources, 19,20 reduced mobility, 21,22 resolution power, 23,24 limit of detection 25,26 and analyte categories. [9][10][11][12][13][14][15][16][17][18] But studies on the measurement of analyte concentration are not as rich as in other areas of research into IMS.…”

Section: Introductionmentioning

confidence: 99%

A novel method to determine the concentration of VOCs at atmospheric pressure

et al. 2014

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A novel method to detect the concentration of electronegative VOCs based on the electron attachment rate at atmospheric pressure, through negative discharge in an ion drift tube, is introduced. When the carrier and drift gas in the drift tube are all high-purity nitrogen, electrons are formed by a negative discharge in the ion source, and are injected into the drift region through the shutter grid. When the electronegative sample molecules are continuously introduced into the drift tube from one end, the neutral molecules are ionized through a collision and capture process with the counterflowing swarm of electrons in the drift region. The electron swarm is exponentially diluted as it travels in the drift region.As a result, negative ions are formed in the drift region and a tail appears in the ion mobility spectrum.These spectra include information such as the intensity of the ions and electrons, the drift time, analyte concentration, the electron capture rate etc. The sample concentration can be calculated using the relative equation including information from the spectrum. As examples, in this work the concentration of electronegative samples of CCl 4 , CHCl 3 , and 1,1,1-C 2 H 3 Cl 3 are studied when the electron energy is about 0.54 eV. The sample concentrations obtained in the experiment using this method are in good agreement with the initial concentrations created using a syringe pump. The comparison shows that the process of utilizing electron capture information to determine concentration is effective. This study provides a novel method to determine the concentrations of VOCs at atmospheric pressure.

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Section: Introductionmentioning

confidence: 99%

A novel method to determine the concentration of VOCs at atmospheric pressure

et al. 2014

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Instrumentation for Sub‐ and Supercritical Fluid Chromatography

Khayamian

Daneshfar

Ghaziaskar

2015

Analytical Separation Science

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This chapter describes an overview of the instrumentation in supercritical fluid chromatography ( SCF ) and its application in different fields of science and industry. The main components of an SCF instrument including mobile phase , pump, injector, column, restrictor, and detector are explained. Recent trends in the modification of these parts are also discussed. Finally, the application of SFC to separate a wide variety of materials, such as food constituents, drugs, biological samples, and natural products, is summarized.

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