Direct contact, dissolution and generation of reactive oxygen species: How to optimize the antibacterial effects of layered double hydroxides

Awassa, Jazia; Ruby, Christian; El-Kirat-Chatel, Sofiane

doi:10.1016/j.colsurfb.2022.112623

Cited by 20 publications

(32 citation statements)

References 120 publications

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“…The fact that these augmentations fall in the same range indicates that the enhanced antibacterial performance of ZnAl NPs in the agar disk diffusion test can be related to Zn 2+ release in broth media. By design, inhibition zones are related to the diffusion of the released cations, 26 which is in agreement with our finding.…”

Section: Structural and Textural Properties Of Znal And Mgal Ldh Npssupporting

confidence: 91%

“…In this context, smaller size LDHs were able to induce an enhanced antibacterial effect due to their larger surface area (in this case, the surface area is 36 times greater for the NPs) and greater mobility of the NPs in a stable suspension promoting more accessible surface and contact with the tested S. aureus bacteria. 26,29,61…”

Section: Resultsmentioning

confidence: 99%

“…Finally, it is important to mention that the contribution of ROS generation to the antibacterial activity of our ZnAl LDH NPs (Mechanism 3) could be eliminated since all experiments were performed inside an incubator in the absence of light and the production of ROS by LDHs is only pronounced in the presence of a suitable light source. 26…”

Section: Resultsmentioning

confidence: 99%

“…26,29,61 Finally, it is important to mention that the contribution of ROS generation to the antibacterial activity of our ZnAl LDH NPs (Mechanism 3) could be eliminated since all experiments were performed inside an incubator in the absence of light and the production of ROS by LDHs is only pronounced in the presence of a suitable light source. 26 Page 15 of 42 Nanoscale As shown in Figure 3a On the other hand, cells treated with antibacterial ZnAl LDH NPs were completely distorted with highly corrugated surfaces presenting hollows and crests (Figure 3c). Similar cells damage observations were previously reported.…”

Section: Nanoscale Accepted Manuscriptmentioning

confidence: 99%

“…16,[21][22][23][24][25] We have recently reviewed the different antibacterial mechanisms of pristine LDHs. 26 The three main mechanisms proposed in the literature are: (1) membrane and cell wall damage by direct interactions with bacterial surfaces; 16,22,27,28 (2) release of constituent divalent metal ions; 16,21,22,24,[27][28][29] and (3) generation of reactive oxygen species (ROS) which are well known to be toxic to the bacteria. 22,24,26,27,29 Despite the fact that these three hypotheses were proposed to explain the antimicrobial effect of pristine LDHs, the role of each antibacterial mechanism in the total antimicrobial action has not been determined because the proof of evidence from a real experimental setup is scarce.…”

Section: Introductionmentioning

confidence: 99%

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Understanding the role of surface interactions in the antibacterial activity of layered double hydroxide nanoparticles by atomic force microscopy

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Section: Structural and Textural Properties Of Znal And Mgal Ldh Npssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Nanoscale Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Understanding the role of surface interactions in the antibacterial activity of layered double hydroxide nanoparticles by atomic force microscopy

et al. 2022

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Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Bian

Cai

et al. 2023

Advanced Science

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Bone diseases including bone defects, bone infections, osteoarthritis, and bone tumors seriously affect life quality of the patient and bring serious economic burdens to social health management, for which the current clinical treatments bear dissatisfactory therapeutic effects. Biomaterial‐based strategies have been widely applied in the treatment of orthopedic diseases but are still plagued by deficient bioreactivity. With the development of nanotechnology, layered double hydroxides (LDHs) with adjustable metal ion composition and alterable interlayer structure possessing charming physicochemical characteristics, versatile bioactive properties, and excellent drug loading and delivery capabilities arise widespread attention and have achieved considerable achievements for bone disease treatment in the last decade. However, to the authors' best knowledge, no review has comprehensively summarized the advances of LDHs in treating bone disease so far. Herein, the advantages of LDHs for orthopedic disorders treatment are outlined and the corresponding state‐of‐the‐art achievements are summarized for the first time. The potential of LDHs‐based nanocomposites for extended therapeutics for bone diseases is highlighted and perspectives for LDHs‐based scaffold design are proposed for facilitated clinical translation.

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Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Li,

Soyhan,

Warszawik

et al. 2024

Advanced Science

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Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in the structural composition and ease of surface modification of LDHs makes it possible to develop specifically functionalized LDHs to meet the needs of different applications. In this review, the recent advances of LDHs for biomedical applications, which include LDH‐based drug delivery systems, LDHs for cancer diagnosis and therapy, tissue engineering, coatings, functional membranes, and biosensors, are comprehensively discussed. From these various biomedical research fields, it can be seen that there is great potential and possibility for the use of LDHs in biomedical applications. However, at the same time, it must be recognized that the actual clinical translation of LDHs is still very limited. Therefore, the current limitations of related research on LDHs are discussed by combining limited examples of actual clinical translation with requirements for clinical translation of biomaterials. Finally, an outlook on future research related to LDHs is provided.

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Direct contact, dissolution and generation of reactive oxygen species: How to optimize the antibacterial effects of layered double hydroxides

Cited by 20 publications

References 120 publications

Understanding the role of surface interactions in the antibacterial activity of layered double hydroxide nanoparticles by atomic force microscopy

Understanding the role of surface interactions in the antibacterial activity of layered double hydroxide nanoparticles by atomic force microscopy

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

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