Direct antiviral effect of cycloferon (10-carboxymethyl-9-acridanone) against adenovirus type 6 in vitro

Zarubaev, Vladimir V.; Slita, Alexander V.; Krivitskaya, Vera; Сироткин, А. К.; Коваленко, А. Л.; Chatterjee, Nando K.

doi:10.1016/s0166-3542(02)00193-6

Cited by 29 publications

(17 citation statements)

References 39 publications

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“…In addition, the following compounds displayed in vitro anti-Ad activity: cyclic D,L--peptides [110], cycloferon [111], lactoferrin [112], medical plant compounds [113], the anti-herpes cobalt chelate CTC-96 (doxovir) [114], heterocyclic Schiff bases of aminohydroxyguanidine tosylate [115], RGD peptidomimetic molecules [116] and small interfering RNAs targeting Ad E1A mRNA [117].…”

Section: Other Targets For Anti-adenovirus Therapymentioning

confidence: 99%

Clinical features and treatment of adenovirus infections

Lenaerts

Clercq

Naesens

2008

Reviews in Medical Virology

205

179

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Adenoviruses (Ads) are common opportunistic pathogens that are rarely associated with severe clinical symptoms in healthy individuals. In contrast, in patients with compromised immunity, Ad infections often result in disseminated and potentially life-threatening disease. Among these are AIDS patients, individuals with hereditary immunodeficiencies and recipients of solid organ or haematopoietic stem cell transplants (HSCT) who receive immunosuppressive therapy. The latter account for the largest number of severe Ad infections. There is currently no formally approved antiviral therapy for the treatment of severe Ad keratoconjunctivitis and life-threatening Ad infections in immunocompromised patients. Here we update current knowledge on Ad biology, the clinical features observed in different patient groups and specific immune responses towards Ad infections. In addition, we review current and future treatment options, including: (i) the antiviral drugs cidofovir, ribavirin and new investigational compounds, as evaluated in the clinic or in relevant animal models, as well as (ii) novel immunotherapeutic strategies.

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Section: Other Targets For Anti-adenovirus Therapymentioning

confidence: 99%

Clinical features and treatment of adenovirus infections

Lenaerts

Clercq

Naesens

2008

Reviews in Medical Virology

205

179

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“…The 1 H NMR spectra were recorded with a Bruker AC 200 Instrument, (Bruker Corp., Karlsruhe, Germany) at 200 MHz and the 13 C NMR spectra were recorded at 50 MHz for solutions in DCCl 3 with tetramethylsilane as the internal standard. 2D NMR spectra were recorded with Bruker AM 500 Instrument at 500 MHz.…”

Section: Chemistrymentioning

confidence: 99%

“…The 13 C NMR assignations were performed using bidimensional techniques. For compounds 3d and 3g, the coupling constants were observed in the 13 C NMR because of the fluorine substituent.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and Evaluation of N-Substituted Acridones as Antiviral Agents against Haemorrhagic Fever Viruses

Sepúlveda

Fascio

Mazzucco

et al. 2008

Antivir Chem Chemother

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Background: In the present study, a series of N-substituted acridone derivatives was synthesized and evaluated against two haemorrhagic fever viruses (HFV). Methods: Compounds were tested against Junin virus (JUNV), an arenavirus agent of Argentine haemorrhagic fever, and dengue virus (DENV), a flavivirus agent of the most prevalent arthropod-borne viral disease in humans. Results: Among tested compounds, two N-allyl acridones (derivatives 3c and 3f) elicited a potent and selective antiviral activity against JUNV (strain IV4454) and DENV-2 (strain NGC) with 50% effective concentration values between 2.5 and 5.5 µM, as determined by virus yield inhibition. No cytotoxicity was detected at concentrations up to 1,000 µM, resulting in selectivity indices >181.8-400.0. Both acridones were effective against a wide spectrum of arenaviruses and the four serotypes of DENV. Furthermore, 3c and 3f failed to inactivate virus before cell infection as well as to induce a refractory state by cell pretreatment, indicating that the inhibitory effect was exerted through a blockade in virus multiplication during the infectious process. Conclusion: These data are the first demonstration that acridone derivatives have a potent antiviral activity that block in vitro multiplication of HFV belonging to Arenaviridae and Flaviviridae, such as JUNV and DENV.

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“…Показаны проникновение Циклоферона в человеческие лимфобластоидные клетки и их ядра, взаимо-действие препарата с ДНК, индукция альфа-IFN и провоспалительных цитокинов [4]. Препарат оказывает прямое антивирусное действие на ре-продукцию аденовируса [32] и вирусов герпеса [7]. Можно предположить, что взаимодействие солей акриданона с нуклеиновыми кислотами меняет их структуру.…”

Section: Discussionunclassified