Direct annulation between glycine derivatives and thiiranes through photoredox/iron cooperative catalysis

Abstract

A visible-light-induced aerobic oxidative [2+3] cycloaddition reaction between glycine derivatives and thiiranes is achieved via a cooperative photoredox catalysis and iron catalysis.

Photocatalytic redox-neutral α-C(sp3)–H pyridination of glycine derivatives and N-arylamines with cyanopyridines

“…According to the experimental results and previous reports, 4,7 a mechanism was proposed in Scheme 3. First, the excited state species 3CzClIPN* is formed under visible light irradiation.…”

“…6 As a consequence, many efforts have been devoted to the modification of glycine derivatives. 7 In this respect, the direct α-C–H arylation of glycine derivatives is one of the most straightforward approaches to access α-aryl glycine derivatives. In 2001, Hartwig developed the palladium-catalyzed α-arylation of imine-protected glycinate with aryl halides to form imine-protected α-aryl glycines.…”

Visible-Light-Driven α-C(sp3)–H Bond Functionalization of Glycine Derivatives

“…The utilization of visible light to drive the α-C(sp 3 )-H alkylation of glycine derivatives represents a versatile method to generate alkylated glycine derivatives or valuable heterocycles via subsequent cascade cyclization [51][52][53][54][55][56][57][58][59]. Various alkyl sources were constantly employed in this alkylation, including β-keto esters, alkyl boronic acids, alkanes, alkyl Katritzky salts, and NHPI esters.…”

DFT study of electron donor-acceptor (EDA) complexes of 1H-indole and benzyl bromide derivatives: mechanism exploration and theoretical prediction

“…Our group has long been committed to the development of new visible-light-induced organic synthesis methods [38][39][40] ; The study of molecular properties and reaction mechanisms through computational chemistry. [41][42][43][44][45][46] Hence, we can raise a number of interesting questions: 1) How does changing the substituents of the donor and acceptor affect the strength of the interaction?…”