Direct and correlated selection response for litter size and litter weight at birth in the first parity in mice

Fernández, Jesús; Mínguez, Almudena Moreno; Gutiérrez, Juan Pablo; Nieto, B.; Piqueras, Pepa; Salgado, C.

doi:10.1016/s0301-6226(97)00146-2

Cited by 11 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…I) for W21 (0.15) was lower than that for W42 (0.21), which was in agreement with the results reported by Eisen and Prasetyo [5] and, in a seminal paper, by Falconer [6]. Estimated heritabilities for these two traits were also in close agreement with those reported by Fernández et al [7] for litter weight using DFREML [23] on the same mice population as analysed here. Heritability estimated using Model HO for WG (0.09) was clearly lower than that for the other traits, but it was in close agreement with the one found for another trait such as litter weight in a similar population [14].…”

Section: Discussionsupporting

confidence: 92%

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Ibáñez‐Escriche

Mínguez²,

Nieto

et al. 2008

Genet. Sel. Evol.

View full text Add to dashboard Cite

-Data from an experimental mice population selected from 18 generations to increase weight gain were used to estimate the genetic parameters associated with environmental variability. The analysis involved three traits: weight at 21 days, weight at 42 days and weight gain between 21 and 42 days. A dataset of 5273 records for males was studied. Data were analysed using Bayesian procedures by comparing the Deviance Information Criterion (DIC) value of two different models: one assuming homogeneous environmental variances and another assuming them as heterogeneous. The model assuming heterogeneity was better in all cases and also showed higher additive genetic variances and lower common environmental variances. The heterogeneity of residual variance was associated with systematic and additive genetic effects thus making reduction by selection possible. Genetic correlations between the additive genetic effects on mean and environmental variance of the traits analysed were always negative, ranging from −0.19 to −0.38. An increase in the heritability of the traits was found when considering the genetic determination of the environmental variability. A suggested correlated canalised response was found in terms of coefficient of variation but it could be insufficient to compensate for the scale effect associated with an increase of the mean.

show abstract

Section: Discussionsupporting

confidence: 92%

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Ibáñez‐Escriche

Mínguez²,

Nieto

et al. 2008

Genet. Sel. Evol.

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 81%

“…Although the heritabilities estimated here using Model 1 for LW (0.10) do not exactly coincide with the one we previously reported of 0.21 [5], both the genetic (0.96) and the phenotypic (0.93) correlations (Tab. I) estimated between LS and LW were very similar to those previously provided (1.00 and 0.96, respectively [5]). This is consistent with other authors: a genetic correlation of 1.0 was reported for LS and LW in mice by Luxford et al [17] and for LS and litter weight at weaning by Luxford and Beilharz [16].…”

Section: Discussioncontrasting

confidence: 81%

Genetic parameters for canalisation analysis of litter size and litter weight traits at birth in mice

et al. 2006

View full text Add to dashboard Cite

-The aim of this research was to explore the genetic parameters associated with environmental variability for litter size (LS), litter weight (LW) and mean individual birth weight (IW) in mice before canalisation. The analyses were conducted on an experimental mice population designed to reduce environmental variability for LS. The analysed database included 1976 records for LW and IW and 4129 records for LS. The total number of individuals included in the analysed pedigree was 3997. Heritabilities estimated for the traits under an initial exploratory approach varied from 0.099 to 0.101 for LS, from 0.112 to 0.148 for LW and from 0.028 to 0.033 for IW. The means of the posterior distribution of the heritability under a Bayesian approach were the following: 0.10 (LS), 0.13 (LW) and 0.03 (IW). In general, the heritabilities estimated under the initial exploratory approach for the environmental variability of the analysed traits were low. Genetic correlations estimated between the trait and its variability reached values of -0.929 (LS), -0.815 (LW) and 0.969 (IW). The results presented here for the first time in mice may suggest a genetic basis for variability of the evaluated traits, thus opening the possibility to be implemented in selection schemes.canalisation / variability / mice / litter size / litter weight

show abstract

“…The genetic correlation between litter size and litter weight is high (0.6 from Rothschild and Bidanel, 1995;0.5 from . In mice, genetic gain in litter size was slightly higher in a divergent selection experiment on litter weight than in a line selected on litter size (Fernandez, 1998). It might be a good idea to use information on litter weight in the selection for litter size.…”

Section: Birth Weight and Survivalmentioning

confidence: 99%

Genetic aspects of piglet survival

Knol¹,

Leenhouwers

Lende

2002

Livestock Production Science

108

105

View full text Add to dashboard Cite

Direct and correlated selection response for litter size and litter weight at birth in the first parity in mice

Cited by 11 publications

References 26 publications

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Genetic parameters related to environmental variability of weight traits in a selection experiment for weight gain in mice; signs of correlated canalised response

Genetic parameters for canalisation analysis of litter size and litter weight traits at birth in mice

Genetic aspects of piglet survival

Contact Info

Product

Resources

About