Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects

Castilho, Miguel; Moseke, Claus; Ewald, Andrea; Gbureck, Uwe; Groll, Jürgen; Pires, Inês; Teßmar, Jörg; Vorndran, Elke

doi:10.1088/1758-5082/6/1/015006

Cited by 194 publications

(165 citation statements)

References 73 publications

(96 reference statements)

Supporting

Mentioning

154

Contrasting

Order By: Relevance

“…29 Due to their excellent biocompatibility and osteoconductivity, CaP ceramic powders, with acid binders such as phosphoric acid / citric acid, are used widely in bone tissue engineering. 13,14,23,30 There are two main approaches to using ceramic powders in the context of 3DP. In the first approach, sacrificial polymeric binders (that pyrolyze upon sintering) 19 are used to improve green strength.…”

Section: Jariwala Et Almentioning

confidence: 99%

“…Castilho et al 23 fabricated 3D biphasic CaP (BCP) scaffolds using a hydraulic setting reaction of HA -TCP powders incorporating phosphoric acid and posttreatment with polylactic -co -glycolic acid solution. They demonstrated that osteoblastic MG63 cell proliferation was greater on BCP composites compared to pure HA or TCP scaffolds.…”

Section: In Vitro and In Vivo Testing Of 3dp Bone Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

3D Printing of Personalized Artificial Bone Scaffolds

Jariwala

Lewis

Bushman

et al. 2015

3D Printing and Additive Manufacturing

131

View full text Add to dashboard Cite

show abstract

Section: Jariwala Et Almentioning

confidence: 99%

Section: In Vitro and In Vivo Testing Of 3dp Bone Scaffoldsmentioning

confidence: 99%

3D Printing of Personalized Artificial Bone Scaffolds

Jariwala

Lewis

Bushman

et al. 2015

3D Printing and Additive Manufacturing

131

View full text Add to dashboard Cite

show abstract

“…The technique of 3D printing consists of applying a layer of powder onto a surface and using an inkjet printer head to precisely spray the surface with a binder to bind the powder particles. The process is repeated by spreading a new layer of powder on top of the previous layer that results in the creation of a 3D structure [8,[21][22][23][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Effect of layer printing delay on mechanical properties and dimensional accuracy of 3D printed porous prototypes in bone tissue engineering

Farzadi

Waran

Solati‐Hashjin

et al. 2015

Ceramics International

104

View full text Add to dashboard Cite

Effect of layer printing delay on mechanical properties and dimensional accuracy of 3D printed porous prototypes in bone tissue engineering, Ceramics International, http://dx. AbstractRecent advancements in computational design and additive manufacturing have enabled the fabrication of 3D prototypes with controlled architecture resembling the natural bone. Powder-based three-dimensional printing (3DP) is a versatile method for production of synthetic scaffolds using sequential layering process. The quality of 3D printed products by this method is controlled by the optimal build parameters. In this study, Calcium Sulphate based powders were used for porous scaffolds fabrication. The X-direction printed scaffolds with a pore size of 0.8 mm and a layer thickness of 0.1125 mm were subjected to the depowdering step. The effects of four layer printing delays of 50, 100, 300 and 500 ms on the physical and mechanical properties of printed scaffolds were investigated. The compressive strength, toughness and tangent modulus of samples printed with a delay of 300 ms were observed to be higher than other samples. Furthermore, the results of SEM and µCT analyses showed that samples printed with a delay of 300 ms have higher dimensional accuracy and are significantly closer to CAD software based designs with predefined 0.8 mm macro pore and 0.6 mm strut size.

show abstract

“…Along with their development in 3D printers, hydrogels can now be printed on any desired substrates free from nozzle clogging. 43 In general, a volume range between 1-100 pL of liquid droplets can escape from the nozzle by a pulse generated at the nozzle orifice. The advantage of 3D printing is in the direct writing of biomaterials and providing inexpensive way for manufacturing devices.…”

Section: D Printing Technologymentioning

confidence: 99%

Advances in 2D/3D Printing of Functional Nanomaterials and Their Applications

Choi

Das

Theodore³

et al. 2015

ECS J. Solid State Sci. Technol.

View full text Add to dashboard Cite

Advanced printing techniques include innovative and/or integrated processes that are used to produce an object with enhanced functionality and with a wide range of applications. This is done by realizing printing of functional materials such as ink, paste, polymer, ceramic powder, and organic materials. Unlike conventional manufacturing methods, a new technique is needed to manipulate small objects to fabricate desired parts, as materials are scaled down to the nanometer range. In this regard, the traditional subtractive production has been changed to a bottom-up approach as device structures have changed to multilayer structures which contain several functional nanomaterials. A powder is used to fabricate an object with a desired geometry. This reduces the material loss due to the bottom-up nature of the process. In this article, we review the current state of knowledge for advanced manufacturing using two methods, 3D printing and roll-to-roll manufacturing. 3D printers developed in the early 1980s1 has created a revolution in research and development and teaching laboratories due to a substantial price drop after 2010 and an easy software called plugplay that allows most people to use it without extensive technical help.2,3 Based on economic analysis, the market for 3D printers is growing significantly. This is driven by a number of sectors including aerospace, automotive, and medical/dental and the market was worth several billions in 2013. During the last decade, the business has increased exponentially due to the 3D printing technology enabling the fabrication of complex objects with enhanced functionalities and improved material properties.4,5 Desktop 3D printers were targeted primarily at hobbyists and consumers who are not in industry. However, the need of industry-level 3D printers has attracted a lot of attention from researchers and scientists in the fields of biotechnology, automotive, architecture, electrical, electronic, photonic, optical, and sensor engineering.6-10 Printers' resolution is dropping under 100 micrometers (250 dot per inch (DPI)) with a typical layer thickness of 100 micrometers. The primary advantage of a 3D printer is its ability to create any shape in the micrometer range up to several meter range depending on the supporting holder.Over the past few years a rapid growth in the 3D printing industry has been observed as evidenced by the enormous numbers of articles published in scientific journals and patents filed as illustrated in Figure 1. Advances in the 3D printing technology will also lead to significant price drop, owing to the fact that a lot of items will be manufactured depending only upon the type and need of the customer. 11This means that household-level production will be much preferred due to broader imagination and creativity of human being. Another implication is that the manufacturing process of any item can be highly customized because altering the items will not require tooling or intensive software development.12 These simplified production processes that were...

show abstract

Direct 3D powder printing of biphasic calcium phosphate scaffolds for substitution of complex bone defects

Cited by 194 publications

References 73 publications

3D Printing of Personalized Artificial Bone Scaffolds

3D Printing of Personalized Artificial Bone Scaffolds

Effect of layer printing delay on mechanical properties and dimensional accuracy of 3D printed porous prototypes in bone tissue engineering

Advances in 2D/3D Printing of Functional Nanomaterials and Their Applications

Contact Info

Product

Resources

About