Direct 2-Arm Comparison Shows Benefit of High-Dose-Rate Brachytherapy Boost vs External Beam Radiation Therapy Alone for Prostate Cancer

External beam radiotherapy plus single-fraction high dose rate brachytherapy in the treatment of locally advanced prostate cancer

“…Our findings corroborate these reports. The main findings of the present study are that EBRT plus a single 9 Gy fraction HDRB boost plus ADT yields results that are at least similar to those achieved with high-dose EBRT plus ADT [9,26].…”

External beam radiation therapy and a low-dose-rate brachytherapy boost without or with androgen deprivation therapy for prostate cancer

“…Similarly, Stone et al (21) reported a bDFS, but no DMFS or OS, benefi t to ADT in patients with a Gleason score 7-10 who underwent LDR brachytherapy ± EBRT (58% of patients received EBRT). However, many other retrospective studies have found no bDFS, DMFS, or OS benefi t to ADT in intermediate-risk or high-risk patients treated with EBRT and a brachytherapy boost (19,(22)(23)(24)(25)(26). Similarly, in this study, there was no signifi cant bDFS, DMFS, or OS benefi t to ADT in intermediate-risk patients treated with EBRT and a LDR brachytherapy boost (Figure-1).…”

Radiation dose escalation or longer androgen suppression for locally advanced prostate cancer? Data from the TROG 03.04 RADAR trial

“…A well designed randomised controlled trial such as the British trial run by Hoskin et al is necessary to provide an appropriate estimate [24]. In the meantime the less accurate estimates may come from the ASCENDE-RT ⁄ trial (Morris et al) and the carefully matched comparison of outcomes between men treated with the HDRB boost regimen that was subsequently used in the RADAR trial, and men treated by EBRT alone using 74 Gy in 37 daily 2 Gy fractions at the Peter McCallum Cancer Institute, Melbourne [25].…”