External beam radiotherapy plus single-fraction high dose rate brachytherapy in the treatment of locally advanced prostate cancer

Boladeras, A.; Santorsa, L.; Gutiérrez, Cristina; Martinez, E.; Pera, J.; Pino, Francisco; Suárez, José Francisco; Ferrer, F.; Díaz, Aurora; Polo, Alfredo; Guedea, Ferrán

doi:10.1016/j.radonc.2014.07.013

Cited by 21 publications

(14 citation statements)

References 46 publications

(61 reference statements)

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“…Recent advances such as intensity-modulated radiation therapy, fractionated delivery regimens and volumetric modulated arc therapy (2-3) aim to reduce toxicity. However, both late and acute symptoms and side effects can still occur and impact on quality of life (QOL) (4,5).…”

Section: Introductionmentioning

confidence: 99%

“…Recent advances such as intensity-modulated radiation therapy, fractionated delivery regimens and volumetric modulated arc therapy 2 , 3 aim to reduce toxicity. However, both late and acute symptoms and side effects can still occur and impact on quality of life (QOL) 4 5 Therefore, robust plans to ensure patients’ supportive needs are met both during treatment and beyond need to be implemented 6 …”

Section: Introductionmentioning

confidence: 99%

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Assessing the information and support needs of radical prostate cancer patients and acceptability of a group-based treatment review: a questionnaire and qualitative interview study

Chauhan

Holch²,

Holborn³

2018

J Radiother Pract

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AimsCurrent literature suggests the information and support needs of oncology patients undergoing radical radiotherapy to the prostate often remain unmet and can impact quality of life. We aimed to explore the effectiveness of delivery and opportunities for service improvement, including a group based treatment review. Methods:Sixty prostate patients completing radical radiotherapy (mean age 70, range 47-79) in a UK cancer-centre completed a self-designed questionnaire assessing information and support.. To explore views on a group-based-treatment-review, 11% took part in a semi-structured interview. Descriptive data were computed and interviews transcribed and analysed thematically. Results:Eighty-seven percent were satisfied with information and support when delivered by radiographers. However, 26% were only 'sometimes' able to complete bladder-filling, suggesting information regarding treatment delays would improve this. 49% preferred both Doctor and Urology nurse reviews whereas 26% preferred nurse only. 70% stated their 'concerns were always addressed' by a nurse and 49% by a Doctor. Interviews revealed that a group review was generally acceptable with peer support an influencing factor. Findings:Overall patients felt their needs were being met. Suggestions for improvement (more information on preparation, side effects and delays) will be implemented locally. Future work will explore the feasibility of group reviews in patients undergoing radical radiotherapy to the prostate. Financial supportThis research received no specific grant from any funding agency, commercial or not-for-profit sectors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing the information and support needs of radical prostate cancer patients and acceptability of a group-based treatment review: a questionnaire and qualitative interview study

Chauhan

Holch²,

Holborn³

2018

J Radiother Pract

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“…3 Dose escalation can be achieved with precise radiotherapy techniques such as 3D-CRT or intensity-modulated radiotherapy (IMRT), or by adding a boost delivered with high-dose rate brachytherapy (HDRB) or IMRT. [4][5][6][7] Overall survival in high risk patients can be further improved by combining EBRT with androgen deprivation therapy (ADT). 8,9 …”

Section: Introductionmentioning

confidence: 99%

Localized prostate cancer treated with external beam radiation therapy: Long-term outcomes at a European comprehensive cancer centre

Boladeras

Martinez

Ferrer

et al. 2016

Reports of Practical Oncology & Radiotherapy

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Results: Median follow-up was 109.6 months (range, 68.3-193.4 and 71.4% (high) (p = 0.0666). Toxicity included rectitis: grade 1 (G1) (277 pts; 32.6%), G2 (108; 12.7%), and G3 (20; 2.6%) and urethritis: G1 (294; 34.6%); G2 (223; 26.2%), and G3 (11; 1.3%). By dose rate (<76 Gy vs. ≥76 Gy), 5 and 10-year BRFS rates were 83.1% and 68.3% vs. 88.4% and 74.8% (p = 0.038). Conclusions:Our results are comparable to other published series in terms of disease control and toxicity. These findings confirm the need for dose escalation to achieve better biochemical control and the benefits of ADT in high-risk PCa patients.

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“…SBRT allows radiation oncologists to deliver a higher dose in far fewer fractions compared with conventional radiation therapy. The prescription of high doses in a single fraction is being used more widely . However, radiation‐induced damage to normal tissues, for instance, peripheral nerves, has been a concern in clinical practice.…”

mentioning

confidence: 99%

“…The prescription of high doses in a single fraction is being used more widely. [2][3][4] However, radiation-induced damage to normal tissues, for instance, peripheral nerves, has been a concern in clinical practice.…”

mentioning

confidence: 99%

Evaluation of radiation‐induced peripheral nerve injury in rabbits with MR neurography using diffusion tensor imaging and T₂ measurements: Correlation with histological and functional changes

Wan

Wang

Zhou

et al. 2015

Magnetic Resonance Imaging

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External beam radiotherapy plus single-fraction high dose rate brachytherapy in the treatment of locally advanced prostate cancer

Cited by 21 publications

References 46 publications

Assessing the information and support needs of radical prostate cancer patients and acceptability of a group-based treatment review: a questionnaire and qualitative interview study

Assessing the information and support needs of radical prostate cancer patients and acceptability of a group-based treatment review: a questionnaire and qualitative interview study

Localized prostate cancer treated with external beam radiation therapy: Long-term outcomes at a European comprehensive cancer centre

Evaluation of radiation‐induced peripheral nerve injury in rabbits with MR neurography using diffusion tensor imaging and T₂ measurements: Correlation with histological and functional changes

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External beam radiotherapy plus single-fraction high dose rate brachytherapy in the treatment of locally advanced prostate cancer

Cited by 21 publications

References 46 publications

Assessing the information and support needs of radical prostate cancer patients and acceptability of a group-based treatment review: a questionnaire and qualitative interview study

Assessing the information and support needs of radical prostate cancer patients and acceptability of a group-based treatment review: a questionnaire and qualitative interview study

Localized prostate cancer treated with external beam radiation therapy: Long-term outcomes at a European comprehensive cancer centre

Evaluation of radiation‐induced peripheral nerve injury in rabbits with MR neurography using diffusion tensor imaging and T2 measurements: Correlation with histological and functional changes

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Evaluation of radiation‐induced peripheral nerve injury in rabbits with MR neurography using diffusion tensor imaging and T₂ measurements: Correlation with histological and functional changes