Diprosopus (partially duplicated head) associated with anencephaly: a case report

Zaitoun, Abd Al Muti; Change, John; Booker, Michael

doi:10.1016/s0344-0338(99)80094-6

Cited by 24 publications

(13 citation statements)

References 15 publications

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“…With the exception of two separate faces rotated in opposite directions, they share a common cranium and trunk (Spencer, ; Winkler et al, ). Several cardiac abnormalities and neural tube defects are observed in diprosopus parapagus (Al Muti Zaitoun et al, ; Winkler et al, ). Dicephalus parapagus: This pair has separate heads and faces, and fusion starts at the level of the thorax. Despite sharing a common heart, these twins have two sets of great vessels (Winkler et al, ).…”

Section: Classificationmentioning

confidence: 99%

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Conjoined twins: From conception to separation, a review

et al. 2017

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Conjoined twins are suggested to result from aberrant embryogenesis. The two main theories proposed to explain the phenomena are fission and fusion. The incidence rate is 1 in 50,000 births; however, since about 60% of the cases are stillborn, the true incidence is approximated at 1 in 200,000. There is a higher predisposition towards female than male gender with a ratio of 3:1. Conjoined twins are classified based upon the site of attachment. The extent of organ sharing, especially the heart, determines the possibility and prognosis of a separation procedure. Meticulous preoperative evaluation, planning, and preparedness of the team are crucial for a successful separation. Separation of conjoined twins poses several technical, legal, and ethical issues. Clin. Anat. 30:385-396, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Classificationmentioning

confidence: 99%

“…With the exception of two separate faces rotated in opposite directions, they share a common cranium and trunk (Spencer, 2003;Winkler et al, 2008). Several cardiac abnormalities and neural tube defects are observed in diprosopus parapagus (Al Muti Zaitoun et al, 1999;Winkler et al, 2008).…”

Section: Parapagusmentioning

confidence: 99%

Conjoined twins: From conception to separation, a review

et al. 2017

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“…In the case presented here, there is no development of cerebrum and cerebellum and developmental abnormality of the brain in such severity has not been reported in sheep or goats. However, in humans, there are reports of anencephaly cooccurring with diprosopus 9 .…”

Section: Discussionmentioning

confidence: 99%

“…These factors cause oocyte structure, maturations and organogenesis alterations probably as a result of some metabolic or circulatory disturbances, on the basis of a not well İleti şim (Correspondence) +90 224 2940823 deniznak@gmail.com series of slight duplication to almost separated individuals and occur extremely rarely in horses, occasionally in dogs and cats, and uncommonly in cattle, pigs and sheep 7,8 . The diprosopus, craniofacial duplication, abnormality, characterized by the presence of 2 faces with a single head on a single trunk, is one of the rarest craniofacial malformations and a rare form of conjoined twinning 9,10 . Diprosopus, have often been reported in calves and lambs [11][12][13] , goats 14 , cats 15 and rarely in foals 16 .…”

Section: Introductionmentioning

confidence: 99%

Bir Kuzuda Nadir Rastlanan Diprosopus, Tetraophthalmus ve Meningoensefalosel Olgusu

Nak¹,

Yılmaz²,

Yilmazbaş³

et al. 2009

Kafkas Univ Vet Fak Derg

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A female, dystocic, two-headed dead lamb from a 3-year old Sakiz sheep is described. The two faces of the foetus fused at occipital, partly parietal and temporal bones on a single trunk. On each face there were two eyes, one ear and one normally developed oral cavity with only one laryngopharynx and oesophagus. A fl accid, hyperemic, membrane-like tissue protruded from the defective frontal and parietal bones. There were no other skeletal abnormalities but incomplete costal articulation. Microscopic examination of the membranous tissue revealed mostly autolytic neurons. Since diprosopus cases with defective skull development and meningoencephalocele are rare events, this case was evaluated for presentation. Keywords: Diprosopus, Lamb, Meningoencephalocele, Tetraophthalmus Bir Kuzuda Nadir Rastlanan Diprosopus, Tetraophthalmus ve Meningoensefalosel Olgusu ÖzetÜç yaşlı Sakız ırkı bir koyundan güç doğumla doğan iki yüzlü, ölü, dişi bir kuzu tanımlandı. İki yüz tek bir gövde üzerine oturmuş, oksipital bölge ile kısmen parietal ve temporal bölgelerden kaynaşmıştı. Her iki yüzde iki göz, birer kulak, normal gelişmiş ağız boşluğu ancak tek bir laringofarinks ve özofagus vardı. Hiperemik ve gevşek zar benzeri bir doku hatalı şekillenmiş frontal ve parietal kemiklerden dışarı çıkmıştı. Kosta kondral eklemler gelişmemişti; başka bir iskelet anomalisi görülmedi. Zarsal dokunun mikroskobik muayenesinde çoğunlukla otolitik nöronlara rastlandı. Yetersiz kafatası gelişimi, meningoensefalosel ile beraber olan ve nadir karşılaşılan diprosopus olgusundan dolayı, bu olgunun sunumu yapıldı.

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“…Craniofacial duplication may occur in combination with a wide range of midline and nonmidline anomalies. Among them, anencephaly is the most severe malformation observed in diprosopus (Riccardi and Bergmann, ; Gorlin, ; al Muti Zaitoun et al, ; Spencer, ). However, anencephaly has never been reported in milder forms of craniofacial duplication.…”

Section: Introductionmentioning

confidence: 99%

Oropharyngeal teratoma, oral duplication, cervical diplomyelia and anencephaly in a 22‐week fetus: A review of the craniofacial teratoma syndrome

Morlino

Castori

Servadei

et al. 2014

Birth Defects Research

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The term "craniofacial teratoma syndrome" is introduced to define this phenotype as a recognizable developmental field defect of the cephalic pole. Developmental pathogenesis is discussed with a focus on pleiotropy and stereotaxis. The observation of midline findings suggestive of holoprosencephaly in a few previously reported cases suggests a role for the sonic hedgehog signaling pathway in this malformation pattern.

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Diprosopus (partially duplicated head) associated with anencephaly: a case report

Cited by 24 publications

References 15 publications

Conjoined twins: From conception to separation, a review

Conjoined twins: From conception to separation, a review

Bir Kuzuda Nadir Rastlanan Diprosopus, Tetraophthalmus ve Meningoensefalosel Olgusu

Oropharyngeal teratoma, oral duplication, cervical diplomyelia and anencephaly in a 22‐week fetus: A review of the craniofacial teratoma syndrome

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