Diphenyl diselenide (PhSe)2 inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability

Rosseti, Isabela Bueno; Rocha, João Batista Teixeira da; Costa, Maricília Silva

doi:10.1016/j.jtemb.2014.08.001

Cited by 36 publications

(19 citation statements)

References 45 publications

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“…Ebselen and its analogues have been reported as antifungal compounds and its activity have been related, at least in part, to the inhibition of H + ‐ATPase ,. Some reports relate the antifungal activity of diselenides to the pro‐oxidant activity of these compounds as well as the increase in ROS production and fungal membrane permeability ,. Ebselen and diselenides have demonstrated activity against Fusarium sp.…”

Section: Introductionmentioning

confidence: 99%

Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

et al. 2017

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Fusarium is an emerging opportunistic fungal pathogen that causes local or systemic infections. The successful use of a therapeutic drug or combination antifungal therapies against Fusarium spp. are compromised because reports of multidrug resistance are currently frequent. Thus, the development of new antifungal capable of combating multidrug‐resistant Fusarium strains becomes necessary. This study presents the synthesis of seven new allylic selenocyanates and their screening against Fusarium spp. Minimum inhibitory concentrations (MICs) of these compounds ranged from 4 to 64 μg mL−1, with the mechanism of action being related to fungal cell membrane disruption. Specific structural changes, such as widespread thinning along the hyphae, were observed by scanning electron microscopy. The effect of selenocyanates on cell viability and genotoxicity are concentration dependent, however they did not cause mutagenicity in human cells. Five selenocyanates were identified as nonirritant by the ex‐vivo HET‐CAM (Hen′s Egg Test‐Chorioallantoic Membrane) method. Allylic selenocyanates represents a promising alternative in the treatment and prevention of fusariosis.

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Section: Introductionmentioning

confidence: 99%

Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

et al. 2017

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“…It is believed that at very low concentrations, the antifungal activity of the (PhSe) 2 is related to the decreased cell growth and biofilm formation of C. albicans . This antifungal activity involves a mechanism that increases reactive oxygen species (ROS) production, promoting permanent damage in the fungal cell membrane, thereby inducing cell death …”

Section: Discussionmentioning

confidence: 99%

“…Studies revealing that (PhSe) 2 administered orally, produced minor toxicological effects in rabbits exposed for a long time . Alone, this compound has antimicrobial activity against pathogenic bacteria, fungi, oomycetes ( Pythium insidiosum ) and antiviral action on Herpes simplex virus 2 infection . Interestingly, this compound interacted synergistically with antifungal drugs against Candida glabrata , Sporothrix brasiliensis and Fusarium spp .…”

Section: Introductionmentioning

confidence: 99%

In vitro combination between antifungals and diphenyl diselenide against Cryptococcus species

Rossato

Loreto

Venturini

et al. 2019

Mycoses

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Summary Cryptococcus species are an encapsulated fungal pathogen that cause cryptococcal meningitis. There are limited therapeutic options for this infection. The management includes the use of different antifungals such as amphotericin B, flucytosine, or fluconazole, either alone or in combination. However, numerous therapeutic failures, as well as the limited effectiveness of such therapeutics, have been described. Diphenyl diselenide is a chemically synthesised molecule with was found to have antimicrobial activity. In this study, we evaluated the antifungal activities of fluconazole, amphotericin B and flucytosine, in combination with diphenyl diselenide against 30 clinical isolates of Cryptococcus spp. using CLSI M27‐A3 method and the checkerboard microdilution technique. Our results show that the combination of flucytosine and diphenyl diselenide displayed 100% of synergism. However, when we analysed (PhSe)2 plus AMB or FLZ we observed around 70% of indifference. Our results suggest that the combination of diphenyl diselenide with other antifungal agents deserves attention as a new option for the development of alternative therapies for cryptococcosis.

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“…Bioilm is deined as a well-organized, three-dimensional social structure surrounded by extracellular matrix and irreversibly bound to the surface, built by microorganisms with altered, with respect to planktonic form, genotype properties [5,6,[8][9][10]. Bioilm enables microorganisms to survive in a changing and unfavorable environment, and therefore is the dominant form of their existence in the nature.…”

Section: Bioilm Deinitionmentioning

confidence: 99%

“…Bioilms created by Candida sp. yeast can reach a thickness of 25-450 μm [1,5,10,11,17]. There are three [6,11] or four [1,18] phases of Candida bioilm formation.…”

Section: Candida Dimorphism and The Bioilm Formationmentioning

confidence: 99%

Candida Biofilms: Environmental and Clinical Aspects

Targalska¹,

Kunicka-Styczyńska²

2018

The Yeast Role in Medical Applications

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Candida spp. strains are characterized by their ability to form a bioilm structure on biotic and abiotic surfaces, causing signiicant problems in many industrial branches and threatening human health. Candida bioilm is a heterogeneous, spatially well-organized structure consisting of planktonic and mycelial yeast forms which are interdependent in the quorum sensing system and surrounded by an extracellular polysaccharide substance. Bioilm-forming microorganisms are characterized by high invasiveness, the ability to cause dangerous and diicult to treat infections. Furthermore, the cells in the bioilm, compared to planktonic forms, show reduced sensitivity to chemical compounds with antifungal activity and increased survival under unfavorable environmental conditions. The chapter focuses on the emergence of antifungal resistance with the development of bioilms. The work presents the examples of antibiotic resistance of a variety of Candida, showing that a group of strains expressing intermediate sensitivity or resistance to the tested antibiotics include both clinical and food-borne isolates. Similarities in enzymatic and biochemical proiles of diferent origin isolates are discussed. A substantial heterogeneity within Candida albicans group is also underlined. Simultaneously, the incidents of biochemical proiles conformity of some clinical and food-borne isolates are presented, which may be a result of Candida transmission via food.

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Diphenyl diselenide (PhSe)2 inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability

Cited by 36 publications

References 45 publications

Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

In vitro combination between antifungals and diphenyl diselenide against Cryptococcus species

Candida Biofilms: Environmental and Clinical Aspects

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