Diphenyl diselenide exerts anxiolytic-like effect in Wistar rats: Putative roles of GABAA and 5HT receptors

Ghisleni, Gabriele; Kazlauckas, Vanessa; Both, Fernanda Lima; Pagnussat, Natália; Mioranzza, Sabrina; Rocha, João Batista Teixeira da; Souza, Diogo O.; Porciúncula, Lisiane O.

doi:10.1016/j.pnpbp.2008.05.008

Cited by 49 publications

(27 citation statements)

References 52 publications

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“…76 The involvement of 5-HT 1A , 5-HT 2A and 5-HT 3 serotonergic receptors as well as a selective inhibition of monoamino oxidase (MAO-A) activity were evidenced in the anxiolytic effect of (m-CF 3 -C 6 H 4 Se) 2 . 85 Our results are in agreement with those of Ghisleni and co-workers 77 who showed the involvement of 5-HT 1A , 5-HT 2A/2c and GABA A receptors as potential mechanisms underlying the anxiolytic-like action of diphenyl diselenide. Oral administration of (m-CF 3 -C 6 H 4 Se) 2 was as effective as diphenyl diselenide in protecting against hepatic damage induced by 2-nitropropane in rats.…”

Section: Disubstituted Diselenidessupporting

confidence: 92%

Diphenyl diselenide a janus-faced molecule

Nogueira

Rocha

2010

J. Braz. Chem. Soc.

198

106

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Este artigo de revisão aborda uma reflexão sobre o potencial terapêutico ou tóxico de compostos orgânicos de selênio, dando particular ênfase ao disseleneto de difenila e alguns dos seus análogos estruturais. Algumas características moleculares relacionadas com a toxicidade e farmacologia do disseleneto de difenila in vitro e in vivo são abordadas. Os artigos revisados, que abordam experimentos in vivo, indicam que a interação do disseleneto de difenila com tióis pode determinar seu potencial farmacológico ou toxicológico. Além disso, uma limitada ativação da rota de toxicidade, isto é, a oxidação controlada de moléculas de alto peso molecular, que contém grupos tióis, poderia contribuir para os efeitos farmacológicos do disseleneto de difenila. Concluise que a síntese de compostos orgânicos de selênio deve ser direcionada para o desenvolvimento de novos disselenetos de diorganoila que possam interagir com alvos moleculares específicos.In this review, we summarized the potential role of synthetic organoseleno compounds as therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, the simplest of the diaryl diselenides, and some of its analogs. We presented the main molecular aspects related to the in vitro toxicity and pharmacology of diphenyl diselenide and also provided in vivo data indicating that the interaction of diphenyl diselenide with thiols can dictate either its toxicological or pharmacological property. The papers covered in this review indicate that a limited activation of the "toxic pathway", i.e., a controlled oxidation of specific high molecular weight thiol-containing molecules could contribute to the pharmacological effects of diphenyl diselenide. In conclusion, this review reinforces the necessity of developing new diorganoyl diselenides that could interact with specific molecular targets.

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Section: Disubstituted Diselenidessupporting

confidence: 92%

Diphenyl diselenide a janus-faced molecule

Nogueira

Rocha

2010

J. Braz. Chem. Soc.

198

106

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“…Although CB 2 cannabinoid receptors are expressed in relatively low levels in the CNS [172] and are not directly associated with psychoactive effects produced by SCBs [173], prolonged activation of CB 2 cannabinoid receptors has been shown to upregulate 5-HT 2A serotonin receptors in mouse prefrontal cortex [174, 175]. 5-HT 2A serotonin receptors are the primary site of action for hallucinogenic drugs [176] and 5-HT 2A serotonin receptor dysfunction has been associated with mental disorders including anxiety [177] and psychosis [178]. Common adverse effects of SCBs, but not Δ 9 -THC, are anxiety and psychosis [179] (Table 1).…”

Section: Scb Toxicity - Cb1 Versus Non-cb1 Cannabinoid Receptor Targetsmentioning

confidence: 99%

Synthetic Pot: Not Your Grandfather’s Marijuana

Ford

Tai

Fantegrossi

et al. 2017

Trends in Pharmacological Sciences

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In the early 2000’s in Europe and shortly thereafter in the USA, it was reported that “legal” forms of marijuana were being sold under the name K2 and/or Spice. Active ingredients in K2/Spice products were determined to be synthetic cannabinoids (SCBs), producing psychotropic actions via CB1 cannabinoid receptors, similar to those of Δ9-THC, the primary active constituent in marijuana. Often abused by adolescents and military personnel to elude detection in drug tests due to their lack of structural similarity to Δ9-THC, SCBs are falsely marketed as safe marijuana substitutes. Instead, SCBs are a highly structural diverse group of compounds, easily synthesized, which produce very dangerous adverse effects occurring by, as of yet, unknown mechanisms. Therefore, available evidence indicates that K2/Spice products are clearly not safe marijuana alternatives.

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“…Based upon this point of view, diphenyl diselenide (PhSe) 2 , an organoselenium compound, has been reported as a potential pharmacological agent (Nogueira et al 2004;Nogueira and Rocha 2010) with antidepressantlike properties (Ghisleni et al 2008;Savegnago et al 2007Savegnago et al , 2008.…”

Section: Introductionmentioning

confidence: 99%