Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system

Rocha, Juliana Trevisan da; Gai, Bibiana Mozzaquatro; Pinton, Simone; Sampaio, Tuane Bazanella; Nogueira, Cristina W.; Zeni, Gilson

doi:10.1007/s00213-012-2675-3

Cited by 19 publications

(4 citation statements)

References 69 publications

(75 reference statements)

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“…63 However, no significant change in MAO activity following treatment with organoselenium compounds has also been reported in rodents by others. 64 In agreement with the latter report, our results showed that dietary exposure to SeMet did not alter the activity of MAO, thereby indicating that this enzyme does not directly contribute to the neurotoxic effects of Se in zebrafish.…”

Section: ■ Discussionsupporting

confidence: 92%

Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio)

Naderi

Salahinejad

Jamwal

et al. 2017

Environ. Sci. Technol.

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The present study was designed to investigate the effects of chronic dietary exposure to selenium (Se) on zebrafish cognition and also to elucidate possible mechanism(s) by which Se exerts its neurotoxicity. To this end, adult zebrafish were exposed to different concentrations of dietary l-selenomethionine (control, 2.3, 9.7, 32.5, or 57.7 μg Se/g dry weight) for 30 days. Cognitive performance of fish was tested using a latent learning paradigm in a complex maze. In addition, we also evaluated oxidative stress biomarkers and the expression of genes involved in dopaminergic neurotransmission in the zebrafish brain. Fish treated with higher dietary Se doses (32.5 and 57.5 μg Se/g) exhibited impaired performance in the latent learning task. The impaired learning was associated with the induction of oxidative stress and altered mRNA expression of dopamine receptors, tyrosine hydroxylase, and dopamine transporter genes in the zebrafish brain. Collectively, our results illustrate that cognitive impairment in zebrafish could be associated with Se-induced oxidative stress and altered dopaminergic neurotransmission in the brain.

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Section: ■ Discussionsupporting

confidence: 92%

Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio)

Naderi

Salahinejad

Jamwal

et al. 2017

Environ. Sci. Technol.

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“…The pathological mechanisms of MDD are far from clear [ 2 , 3 ] and are a hot topic for neuroscience research [ 4 , 5 ]. Previous studies have pointed out that the mechanism of depression is majorly due to the monoamine neurotransmitters, including norepinephrine (NE), serotonin (5-HT), and dopamine (DA) [ 6 , 7 ], because most of the first choice antidepressants affect 5-HT and NE or 5-HT reuptakes. However, even though many studies support the role of the central monoamine network, other hormones or neuromodulators are involved too, such as hormones released from the hypothalamus-pituitary axis (HPA) [ 8 ] and sex hormones [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats

et al. 2018

Neural Plasticity

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Objective Previously, we have shown that Danshen-Honghua (DSHH) for cognitive deficits after ischemia induced impairments of the hippocampus. Here, we investigate the effects of DSHH on stress-induced depression in menopausal rats. Methods A rat model with menopausal depression was established with bilateral ovariectomies in female SD rats followed by chronic mild stress treatment for 21 days. 40 rats were randomly divided into the sham surgery group (sham surgery and no stress treatment), surgery group (surgery with no stress treatment), surgery/stress group (surgery and stress treatment), fluoxetine group (2.4 mg·kg−1, with surgery and stress treatment), and DSHH group (35 g·kg−1, with surgery and stress treatment). The rats in the last two groups were treated with stresses together with intragastric drug administration for three weeks after the surgery. Then open-field locomotor scores and sucrose intake were tested for behavior changes. Also, the levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and cortisone were determined by high-performance liquid chromatography (HPLC). Serum estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were determined by radioimmunoassay. Results The results of open-field locomotor scores, sucrose intake in both the fluoxetine group and DSHH group, were significantly higher than those of the surgery/stress group (P < 0.01). Serum LH, FSH, and cortisone levels in both the DSHH group and fluoxetine group were significantly lower than those in the surgery/stress group (P < 0.01). Serum E2 levels in these groups were slightly increased in these medicine groups (P < 0.01). The monoamine levels in the DSHH group were much higher than those in the surgery/stress group (P < 0.01). Conclusion DSHH can ameliorate stress-induced depressed syndromes in the surgery/stressed rats via regulating LH and FSH levels as well as monoamine levels.

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“…Of particular importance, our group and others are dedicated to evaluating the antioxidant properties of the simple diaryldiselenide, diphenyl diselenide (PhSe) 2 . Pharmacological properties of (PhSe) 2 has been described in experimental models of central nervous system (CNS) pathologies, including Parkinson's disease [10] , Alzheimer's disease [11] , methylmercury-induced neurotoxicity [12] , and as antidepressive therapy [13] . Some in vitro studies were performed to evaluate the mechanisms involved in the cytoprotective effect of (PhSe) 2 against different oxidative stress conditions.…”

Section: Introductionmentioning

confidence: 99%

Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system

et al. 2019

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Oxidative stress and mitochondrial dysfunction are critical events in neurodegenerative diseases; therefore, molecules that increase cellular antioxidant defenses represent a future pharmacologic strategy to counteract such conditions. The aim of this study was to investigate the potential protective effect of (PhSe)2 on mouse hippocampal cell line (HT22) exposed to tert-BuOOH (in vitro model of oxidative stress), as well as to elucidate potential mechanisms underlying this protection. Our results showed that tert-BuOOH caused time- and concentration-dependent cytotoxicity, which was preceded by increased oxidants production and mitochondrial dysfunction. (PhSe)2 pre-incubation significantly prevented these cytotoxic events and the observed protective effects were paralleled by the upregulation of the cellular glutathione-dependent antioxidant system: (PhSe)2 increased GSH levels (> 60%), GPx activity (6.9-fold) and the mRNA expression of antioxidant enzymes Gpx1 (3.9-fold) and Gclc (2.3-fold). Of note, the cytoprotective effect of (PhSe)2 was significantly decreased when cells were treated with mercaptosuccinic acid, an inhibitor of GPx, indicating the involvement of GPx modulation in the observed protective effect. In summary, the present findings bring out a new action mechanism concerning the antioxidant properties of (PhSe)2. The observed upregulation of the glutathione-dependent antioxidant system represents a future pharmacologic possibility that goes beyond the well-known thiol-peroxidase activity of this compound.

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Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system

Abstract: (PhSe)₂ treatment could influence mood and behavior, indicating a promising role of this organoselenium compound in the management of postmenopausal depressive symptoms.

Cited by 19 publications

References 69 publications

Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio)

Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio)

Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats

Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system

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