Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype

Kim, Seung Hyun; Choi, Hyunna; Yoon, Moon-Gyung; Ye, Young-Min; Park, Hae‐Sim

doi:10.1016/j.anai.2014.12.003

Cited by 35 publications

(26 citation statements)

References 34 publications

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“…The candidate genes implicated (CD58, DPP10) 651 are quite novel and may lend S111 630 compared CRSwNP patients according to S aureus carriage. Even though limited to 39 candidate SNPs, they identified several candidate genes, notably in the area of pathogen engulfment and destruction.…”

Section: Viiic1h Crswnp Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Viiic1h Crswnp Pathophysiologymentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

View full text Add to dashboard Cite

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“…The association was also correlated with serum DPP10 levels. This association, and correlation with serum DPP10, was replicated in a follow-up association study in 272 AERD patients, 272 ATA and 99 healthy controls of Korean ethnicity 41 . In addition, there was a significant correlation of serum DPP10 levels with the serum levels of 15-HETE, an arachidonic acid pathway metabolite that is released at higher levels in eosinophils from severely affected AERD patients 41 .…”

Section: Update On the Genetics Of Aerdmentioning

confidence: 66%

“…This association, and correlation with serum DPP10, was replicated in a follow-up association study in 272 AERD patients, 272 ATA and 99 healthy controls of Korean ethnicity 41 . In addition, there was a significant correlation of serum DPP10 levels with the serum levels of 15-HETE, an arachidonic acid pathway metabolite that is released at higher levels in eosinophils from severely affected AERD patients 41 . While the biological roles of DPP10 in asthma tolerant asthma are unclear, its increased serum protein levels and correlation with serum 15-HETE suggest that these may be protein biomarkers for AERD 41 .…”

Section: Update On the Genetics Of Aerdmentioning

confidence: 66%

Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease

Dahlin

Weiss

2016

Immunology and Allergy Clinics of North America

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“…Als Surrogatparameter publizierten ferner Kim et al kürzlich [25] die DPP10 (Dipeptidyl-peptidase 10) als möglichen Biomarker für ASS-sensitives Asthma. Prospektive Kohortenstudien sind nun notwendig, um diese Marker auch als potenziell prognostische Biomarker zu evaluieren.…”

Section: Introductionunclassified

Individualisierte, personalisierte, stratifizierte Medizin: eine Herausforderung für die Allergologie in der HNO?

Chaker

Klimek

2015

HNO

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Individualized, personalized or stratified medicine approaches offer emerging opportunities in the field of allergy and ENT. Avoidance of side effects, targeted therapy approaches and stratified prevention promise better outcomes and optimal results for patients. Conceptual incongruencies remain with regard to definitions and perceptions of "personalized medicine". Serious ethical considerations have to be taken into account. The development of pharmacogenomics, molecular phenotyping, genomic sequencing and other -omics opens the door to unique mechanistic therapeutic advances. The molecular allergology and recombinant diagnostics available are tools that offer substantial improved diagnostics for the benefit of allergic patients, e. g. in anaphylaxis and food allergy. For stratified therapeutic approaches, however, regulatory affairs will have to keep pace with medical and scientific discovery.

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Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype

Cited by 35 publications

References 34 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease

Individualisierte, personalisierte, stratifizierte Medizin: eine Herausforderung für die Allergologie in der HNO?

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