Dip coating assisted polylactic acid deposition on steel surface: Film thickness affected by drag force and gravity

Fang, Hsu Wei; Li, Kuo Yen; Su, Tai Lun; Yang, Thomas C.-K.; Chang, Ji Sheng; Lin, Po Liang; Chang, Wen Chung

doi:10.1016/j.matlet.2008.04.046

Cited by 42 publications

(25 citation statements)

References 10 publications

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“…comparing to F9,B1 with (15%kol.+0.3% xan.) which might be attributed to the reduction in the viscosity of the coating dispersion in these formulas, an effect which withdrawal that reduces the volume of the liquid deposited on the tablet surface leading to a thinner film layer 29,30,31 . On the other hand, the significant increase in the coated tablet weight and thickness which were detected in OST formulas F12,F13,B4 and B5 double and triple coated respectively with (15% kol.+0.3% xan.)…”

Section: Pre-compression and Post-compression Parameters Of The Prepamentioning

confidence: 99%

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

Mahdi

Maraie

2015

PBJ

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Different tablet dosage forms were prepared to be administered for patients with dysphagia (swallowing difficulties) like buccal, sublingual and orodispersible tablets, however, they possesses certain constrains like taste masking difficulties, limitations in drug and dose selection and friability. Hence, in an attempt to overcome these constrains, a new easily swallowed immediate release tablets containing (160mg) Valsartan were prepared, and designed to be slippery upon contact with saliva giving an easy swallowing of the intact tablet (without water) with efficient taste masking effect, thus, they called Oroslippery tablets (OSTs). Core tablets were prepared by direct compression using different superdisintegrants, followed by dipping in special coating dispersion containing different proportion of kollicoat IR (film former) and xanthan gum (slipperiness inducer) at different coating levels. These OSTs were optimized for their physical properties, in-vitro disintegration and release in addition to in-vivo slipperiness and taste masking effect. It was found that F12 containing 6% crosscarmellose sodium double coated with 15% kollicoat IR and 0.3% xanthan gum possessed a good mechanical strength (hardness=5.69±0.58 Kg/cm 2 , friability=0.09%±0.79), suitable in-vivo slipperiness and taste masking times (8±1.45 and 58±2.18 seconds) respectively, with longer disintegration time (5.57±1.36 minutes) but similar release profile to the commercial conventional tablet Diovan ® with similarity factor (f2= 68.4±1.07) and difference factor (f1= 1.39± 0.95). Therefore, this study developed a new easily swallowed tablet with an efficient taste masking property, high loading capacity and adequate mechanical strength that can be used as an alternative to buccal, sublingual and orodispersible tablets.

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Section: Pre-compression and Post-compression Parameters Of The Prepamentioning

confidence: 99%

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

Mahdi

Maraie

2015

PBJ

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“…The basic principle of dip coating is to deposit thin films of polymer solution on a substrate by immersing the substrate in a polymer solution for some time and then withdrawing the substrate from the polymer solution bath [3]. Many of the previous studies of dip coating processes [4][5][6][7][8][9][10] were designed to determine the effect of coating process parameters on the layer thickness. The layer thickness depends on, for example, withdrawal rate, number of dip cycles, and physical properties of the fluid.…”

Section: Introductionmentioning

confidence: 99%

Modeling and Analysis of the Effect of Dip-Spin Coating Process Parameters on Coating Thickness Using Factorial Design Method

Buapool

Thavarungkul

Srisukhumbowornchai

et al. 2017

Advances in Materials Science and Engineering

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Statistical modeling of the dip-spin coating process to describe colloidal PTFE dispersion coating on the external surface of a small diameter hollow tube was developed by using 2 4 factorial design with a center point to predict the coating thickness in a range of 4-10 m. The coating parameters included viscosity, withdrawal rate, spin speed, and immersion time. The adequacy of the predicted model was verified by coefficients of determination and lack-of-fit test. Model accuracy was verified by comparing predicted values with experimental results. The significant interaction effects on the coating thickness were three-way interaction among withdrawal rate, spin speed, and immersion time and two-way interactions between viscosity and withdrawal rate, viscosity and spin speed, and viscosity and immersion time. Cube plot for coating thickness reveals a trend of increasing coating thickness towards high levels of viscosity, withdrawal rate, and immersion time and lower level of spin speed.

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“…Also, a non-significant increase in the coated tablet weight and thickness was detected between the mono coated formulas themselves (F1, F3, and F5) and also between the double coated formulas themselves (F2, F4, and F6) where different coating solution T1, T2 and T3 used. This was attributed to the slight increase in the viscosity of the enteric coating formulas resulting from increasing eudragit L-100 concentration from 13.5% in (F1, F2) to 15.5% and 17.5% in (F3, F4) and (F5, F6) respectively, an effect which might increase the hydrodynamic drag during the dipping process [22][23][24]. Furthermore, non-significant differences were observed in the hardness between the core and coated tablets and between the coated tablets themselves indicating that the enteric oroslippery coating formula had a negligible effect on the hardness.…”

Section: Resultsmentioning

confidence: 99%

Application of the New Oroslippery Technology in the Preparation of Enteric Slippery Coated Tablet of Naproxen

Maraie

Alhamdany

2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to formulate enteric coated oroslippery tablets (OSTs) of naproxen to overcome the common problems of stomach irritation and swallowing difficulties which accompanied the administration of naproxen tablets.Methods: Different formulas of enteric slippery tablets were prepared by direct compression method. Various parameters were investigated like the effect of eudragit L-100 (eud.) concentration (as an enteric polymer), coating level and effect of different concentrations of croscarmellose sodium CCS (as super disintegrant) on the physical properties. Finally, in an in vitro disintegration and release study was carried out. Results:The enteric slippery optimal formula (F8) was selected to consist of double coat (17.5% eudragit (eud.)) with core tablet containing (6% CCS). It was found that this optimal formula having an acceptable physical property (friability, hardness, thickness and weight variation). Besides, the best acid resistant potential represented by the protection of the OSTs for 2 h in 0.1 N HCl without any sign of disintegration and drug release. Moreover, it was found that (F8) has a disintegration time equal to (8±1.36 min) and release of 80% (20±0.18 min) in phosphate buffer pH 6.8. Conclusion:The result revealed the successful preparation of naproxen tablets using enteric slippery coating that can be easily swallowed and prevent direct irritation of the stomach with acceptable tablet weight.

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Dip coating assisted polylactic acid deposition on steel surface: Film thickness affected by drag force and gravity

Cited by 42 publications

References 10 publications

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

New Easily Swallowed Tablets with Slippery Coating for the Antihypertensive Drug Valsartan

Modeling and Analysis of the Effect of Dip-Spin Coating Process Parameters on Coating Thickness Using Factorial Design Method

Application of the New Oroslippery Technology in the Preparation of Enteric Slippery Coated Tablet of Naproxen

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