Application of the New Oroslippery Technology in the Preparation of Enteric Slippery Coated Tablet of Naproxen

Maraie, Nidhal K.; Alhamdany, Anas Tarik; H, Mahdi Zainab

doi:10.22159/ijpps.2017v9i6.18676

Cited by 4 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7) revealed that a significant increase in taste masking in coated tablets (T1-T6) than the non-coated core tablet, because coating the tablet created a physical barrier between the drug and taste buds, In addition, the use of mannitol and peppermint oil resulted in a fine sweet taste, sense of coolness and freshness within the mouth [29,30]. Furthermore, the results showed a significant increase (p<0.05) in taste masking at the higher concentration of Kollicoat IR represented in T5 (19% Kollicoat) comparing to T1 with (9% Kollicoat) and T3 with (14% Kollicoat), in addition the results showed that double coating which represented in T2, T4, and T6 formulas, have a significant improvement(P<0.05) in the in vivo taste masking effect comparing to monolayer coating in T1,T3, and T5, respectively, these results might be due to the greater viscosity of the coating dispersion that observed by the higher Kollicoat concentrations in T6 which increased the hydrodynamic drag of the coating dispersion that finally gave a higher coat thickness [3].…”

Section: In Vivo Slipperiness and Taste Masking Effect Of The Preparementioning

confidence: 84%

“…The volunteers were told to roll the tablet gently in their oral cavity without chewing or biting; whenever a slight taste of bitterness can be detected the volunteered were informed to spit the tablet out along with the saliva and to rinse their mouth immediately. The time required for bitterness sensation was recorded and considered as an indicator for taste masking property for the prepared RHCl OSTs [3].…”

Section: In Vivo Evaluation Of Slipperiness and Taste Masking Effectmentioning

confidence: 99%

“…The drugs are administered via the oral route without the aid of chewing or prior dispersion/dissolution in water so a systemic effect can be produced [1,2]. So far, oroslippery tablets (OSTs), a new tablet dosage form, had been developed to avoid dysphagia as well as optimizing the traditional tablet dosage form, this dosage form relays on hydration of the tablet inside the oral cavity which offers slipperiness easily of an intact tablet without water aid, moreover, it provide taste masking through the same concept [3].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Design and Characterization of Oroslippery Buoyant Tablets for Ranitidine Hydrochloride

Maraie

Salman

Yousif

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The goal behind of performing this study was to come out with an oroslippery buoyant ranitidine hydrochloride tablet to ease the swallowing process. Hence, the drug is released controllably in the stomach regardless of the effect on gastric emptying time. Materials and Methods:The core of the buoyant containing 150 mg of the drug was compressed directly, and sodium bicarbonate was employed as an effervescent agent, besides, hydroxyl propyl methyl cellulose (HPMC) polymer was utilized in different grades in the formulation process. The prepared core was immersed in the coating dispersion, which was formulated using xanthan gum (slipping agent) and Kollicoat instant release (IR) (for film formation). According to the variables in the formulation process, floating properties varies along with the release profile of the drug; therefore, investigation of the effects of variables was conducted, including polymer type and concentration in the core part, and the effect of Kollicoat IR amount as well as the level of coating.Results: According to this study, it was clearly obvious that T4 formulation, that consisted of HPMC K4M, after being dipped 2 times in dispersion of 0.3% xanthan gum and 14% Kollicoat IR, had provided an instant floating, moreover, the in vivo slipperiness was quite acceptable as well as the taste masking. Nevertheless, the percentage of drug release measured after 6 h was 90.15%. Conclusion:The resultant formulas is quite promising to take the lead as new approach to easy swallowing tablets without need of water especially for patients with swallowing problems as well as it is floating tablet that can retain the drug in gastric cavity to be continuously released to ensure its maximum absorption and may improve its bioavailability.

show abstract

Section: In Vivo Slipperiness and Taste Masking Effect Of The Preparementioning

confidence: 84%

Section: In Vivo Evaluation Of Slipperiness and Taste Masking Effectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design and Characterization of Oroslippery Buoyant Tablets for Ranitidine Hydrochloride

Maraie

Salman

Yousif

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Preparation of ASA enteric-coated tablets The enteric-coated tablets for delayed-release have these steps [10,11].…”

Section: Preparation Of Tabletsmentioning

confidence: 99%

A Novel Approach in Designing Enteric-Coated Antiplatelet Drug for Bypassing Stomach and Gastric Irritation

Naik

Purushothaman

Sekhar

2020

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The innovative approach in this investigation is making an enteric-coated acetylsalicylic acid (ASA) for antiplatelet activity using a novel excipient. Methods: A novel methodology used in making ASA tablets for tackling the stomach irritation of ASA, by including Plantago ovata seed mucilage as a tablet binder. ASA compatibility with P. ovata seed mucilage was judged by differential scanning calorimetry (DSC) and Fourier Transform Infrared (FTIR) studies. All tablets were prosecuted for flow properties, physicochemical constraints, and release. Results: The enteric-coated tablets established no interface by FTIR and DSC lessons. All the tablets possessed physicochemical constraints. The ASA showed its opposition to discharge in the stomach (2 h) and errand in a basic buffer (within 45 min). Conclusions: The work revealed that with the help of P. ovata as a tablet binder will resolve the disputes connected to gastric irritation.

show abstract

“…The spectra FT-IR supports in comparing with a standard FT-IR spectrum of the pure drug to detect any physicochemical incompatibility between the drug and different excipients. 28…”

Section: Drug-excipients Compatibility Study and Identification Fourimentioning

confidence: 99%

Floating Microspheres of Enalapril Maleate as a Developed Controlled Release Dosage Form: Investigation the Effect of Ionotropic Gelation Technique

Abbas¹,

Alhamdany²

2018

tjps

View full text Add to dashboard Cite

The purpose of this study is to provide a control drug delivery system through a newly approved work to enhance absorption and bioavailability of enalapril maleate loaded floating microspheres by ionotropic gelation technique using a hydrophilic carrier. Methods: Over this study, eleven developed formulations of floating microspheres were prepared by ionotropic gelation method using different concentrations of sodium alginate, iota carrageenan, sodium bicarbonate, calcium chloride, and the drug. Characterization of these microspheres was done using a diversity of parameters like micrometric properties, percentage yield, entrapment efficiency, In-Vitro buoyancy, In-Vitro drug release, and kinetics of drug release. The optimum formula was evaluated and identified for drugexcipients compatibility using Fourier transform infrared spectroscopy (FT-IR), surface morphology, powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). Results: From the results; F4 was selected as an optimum formula since it provides a faster and premium release of drug from the matrix (91.4%). Kinetics of drug release was founded to depend on both diffusion and erosion mechanisms, as the correlation coefficient (R 2) was best fitted with Korsemeyer model and release exponent (n) shown to be between 0.43-0.84. SEM images demonstrate spherical, discrete and freely flowing microspheres with a particle size of 199.4 ± 0.04. Optimum buoyancy properties, percentage yield, and drug entrapment efficiency were achieved. FTIR decided no interaction between enalapril and the polymers. DSC and XRD ascribed the miscibility of the drug with the polymers while maintaining stable crystalline properties of enalapril loaded in the prepared microspheres. Conclusion: It can be concluded that the developed floating microspheres of enalapril maleate can be considered as a promising controlled drug delivery system; thereby improve patient compliance.

show abstract

Application of the New Oroslippery Technology in the Preparation of Enteric Slippery Coated Tablet of Naproxen

Cited by 4 publications

References 12 publications

Design and Characterization of Oroslippery Buoyant Tablets for Ranitidine Hydrochloride

Design and Characterization of Oroslippery Buoyant Tablets for Ranitidine Hydrochloride

A Novel Approach in Designing Enteric-Coated Antiplatelet Drug for Bypassing Stomach and Gastric Irritation

Floating Microspheres of Enalapril Maleate as a Developed Controlled Release Dosage Form: Investigation the Effect of Ionotropic Gelation Technique

Contact Info

Product

Resources

About