Dioxomolybdenum(VI) complexes of hydrazones of two substituted salicylaldehydes: synthesis, structures, and catalytic properties

Abstract

Dioxomolybdenum(VI) complexes [MoO 2 L(CH 3 OH)] (L = L 1 = N′-(2-hydroxy-5nitrobenzylidene) isonicotinoylhydrazide for 1, L= L 2 = N′-(4-diethylamino-2-hydroxybenzylidene)-4-methylbenzohydrazide for 2) were prepared and structurally characterized by physicochemical and spectroscopic methods and single-crystal X-ray determination. Mo in the complexes is octahedrally coordinated. Both complexes show effective catalysis in oxidation of cyclohexene, vinylbenzene, 1-butylene, and 1-pentene, to their corresponding epoxides. In general, high epoxide yields (over 89%) and selectivity (100%) were observed for all aliphatic and aromatic substrates.

Cancer cell growth inhibition by aroylhydrazone derivatives

“…Salicylaldehyde was obtained from Merck (Germany), o-vanillin, nicotinic acid and iso-nicotinic acid hydrazides were purchased from Fluka (Switzerland); benzaldehyde, 2,4-dihydroxybenzaldehyde, 2-hydroxy-4- chlorobenzaldehyde and 3,5-dichloro-2-hydroxy benzaldehyde purchased from Sigma (Switzerland). All hydrazones were synthesized in the University of Zagreb, according to previously described procedures [29,34,[42][43][44][45]. They were obtained by the condensation reaction of equimolar amounts of the corresponding aroylhydrazide (nicotinic hydrazide for 1-12 and isonicotinic hydrazide for A-E) and differently substituted aldehydes or ketones The reactions were carried out in dry alcohol (ethanol or ethanol) under argon atmosphere at 85 C for 20 h. The solvent was evaporated and the solids were suspended in CH 2 Cl 2 , filtered (G-3), rinsed with CH 2 Cl 2 (EtOH was used for 4, 5, 11 and 12), and dried at 50 C over 24 h.…”