Dioxins and endometriosis: a plausible hypothesis.

Birnbaum, Linda S.; Cummings, Audrey M.

doi:10.1289/ehp.0211015

Cited by 99 publications

(56 citation statements)

References 54 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Environmental toxins, including dioxin, have been implicated as risk factors of endometriosis [29]. It was stated that phase I drug-metabolizing enzymes (DMEs) metabolized toxic compounds to genotoxic electrophilic intermediates, and phase II DMEs conjugate the intermediates to water-soluble deriva tives, completing the detoxification cycle [30].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis

Fan

Huang

Xiao

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Cytochrome P450 1A1 (CYP1A1) polymorphisms were implicated in endometriosis risk, but individual published studies showed inconclusive results. Thus, a metaanalysis was performed to clarify the effect of CYP1A1 polymorphisms on endometriosis risk. Methods PubMed, Embase, and CNKI databases were searched to identify the eligible studies focusing on the associations between CYP1A1 MspI and Ile462Val polymorphisms and susceptibility to endometriosis. Summary odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for CYP1A1 polymorphisms and endometriosis were calculated. Results Pooled analysis of 12 studies involved a total of 1555 cases and 2868 controls showed that in all genetic models, no significant association between CYP1A1 MspI polymorphism and endometriosis risk was observed in the overall, Asians and Caucasians population, respectively. Interestingly, increased endometriosis risk was associated with carrying the C allele of CYP1A1 combined with GSTM1 null genotypes. For CYP1A1 Ile462Val polymorphism, eight studies were available (878 cases and 1991 controls). In the overall analysis, CYP1A1 Ile462Val polymorphism had a statistically significant association with increased endometriosis risk in allele contrast and all genetic models except the model of Val/Ile vs. Ile/Ile. In the subgroup analysis by ethnicity, significant elevated endometriosis risk was associated with CYP1A1 Ile462Val polymorphism in Asians but not in Caucasians under all genetic models. No publication bias was found in the present studies. Conclusions This meta-analysis suggested that CYP1A1 Ile462Val polymorphism was associated with an increased risk of endometriosis, particularly in Asians. CYP1A1 MspI polymorphism may not be associated with endometriosis risk, but GSTM1 and CYP1A1 MspI polymorphism may have a joint effect on endometriosis risk.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The products of CYP1A1 are involved in estrogen and PAH metabolism. It was shown that CYP1A1 was involved in metabolism of dioxin, which may increase the incidence and severity of endometriosis in monkeys [29]. Moreover, CYP1A1 is also involved in estrogen metabolism, catalyzing the hydroxylation of 17β-estradiol at the C-2 position [31].…”

Section: Discussionmentioning

confidence: 99%

The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis

Fan

Huang

Xiao

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…These alterations may induce endometriosis or cancer by altering a dioxininduced oestrogen growth signal. Dioxins are environmental contaminants, and have been shown to induce endometriosis-like and oestrogen-dependent tumours in animal models (Birnbaum & Cummings 2002). Of importance, there is a doubled risk of developing endometriosis amongst women with high serum dioxin levels (Eskenazi et al 2002).…”

Section: Self-sufficiency In Growth Signalsmentioning

confidence: 99%

“…Like sporadic cancer (Balmain et al 2003), endometriosis may be considered to arise by complex interactions between inherited germline polygenic low-penetrance alleles (polymorphisms) (Hadfield et al 2001, somatically acquired genetic alterations , environmental factors (Birnbaum & Cummings 2002), and the processes of the hallmarks of cancer described earlier.…”

Section: Implications Of the 'Endometriosis Is A Neoplastic Process' mentioning

confidence: 99%

Endometriosis and the neoplastic process

Varma¹,

Rollason²,

Gupta³

et al. 2004

Reproduction

184

146

View full text Add to dashboard Cite

Endometriosis is a frequent disorder that commonly presents with infertility and pelvic pain. Although the precise aetiology of endometriosis is unclear, it is generally considered to involve multiple genetic, environmental, immunological, angiogenic and endocrine processes. Genetic factors have been implicated in endometriosis but the susceptibility genes remain largely unknown. Although endometriosis is a benign disorder, recent studies of endometriosis suggest endometriosis could be viewed as a neoplastic process. Evidence to support this hypothesis includes the increased susceptibility to develop ovarian clear-cell and endometrioid cancers in the presence of endometriosis, and molecular similarities between endometriosis and cancer. In this article we discuss (i) the evidence suggesting that endometriosis might be viewed as a neoplastic process, and (ii) the implications of this hypothesis for elucidating the pathogenesis of endometriosis and developing novel methods of diagnostic classification and individualised treatments.

show abstract

“…Moreover, estrogens seem to be involved in maintaining the male skeleton (11). Thus one possible hypothesis is that dioxins or other POC act as endocrine disruptors and modulate the homeostasis of estrogens or other steroid hormone systems (12).…”

mentioning

confidence: 99%