The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis

Abstract

Purpose Cytochrome P450 1A1 (CYP1A1) polymorphisms were implicated in endometriosis risk, but individual published studies showed inconclusive results. Thus, a metaanalysis was performed to clarify the effect of CYP1A1 polymorphisms on endometriosis risk. Methods PubMed, Embase, and CNKI databases were searched to identify the eligible studies focusing on the associations between CYP1A1 MspI and Ile462Val polymorphisms and susceptibility to endometriosis. Summary odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for CYP1A1 polymorphisms and endometriosis were calculated. Results Pooled analysis of 12 studies involved a total of 1555 cases and 2868 controls showed that in all genetic models, no significant association between CYP1A1 MspI polymorphism and endometriosis risk was observed in the overall, Asians and Caucasians population, respectively. Interestingly, increased endometriosis risk was associated with carrying the C allele of CYP1A1 combined with GSTM1 null genotypes. For CYP1A1 Ile462Val polymorphism, eight studies were available (878 cases and 1991 controls). In the overall analysis, CYP1A1 Ile462Val polymorphism had a statistically significant association with increased endometriosis risk in allele contrast and all genetic models except the model of Val/Ile vs. Ile/Ile. In the subgroup analysis by ethnicity, significant elevated endometriosis risk was associated with CYP1A1 Ile462Val polymorphism in Asians but not in Caucasians under all genetic models. No publication bias was found in the present studies. Conclusions This meta-analysis suggested that CYP1A1 Ile462Val polymorphism was associated with an increased risk of endometriosis, particularly in Asians. CYP1A1 MspI polymorphism may not be associated with endometriosis risk, but GSTM1 and CYP1A1 MspI polymorphism may have a joint effect on endometriosis risk.

Defining the genetic profile of endometriosis (Review)

“…AhRR codon 185 variation has been reported to be associated with the susceptibility to and severity of endometriosis in a Japanese population (56). This pronounced inclination in an Asian population has also been recorded elsewhere; in a meta-analysis examining the effects of CYP1A1A polymorphisms in disease risk, Ile462Val polymorphism was found to be associated with an increased risk (57). Moreover, in patients of Asian origin, polymorphism rs700519 has been shown to be related to the riskt of developing endometriosis, while among Caucasians, the same meta-analysis revealed that the putative endometriosis-associated genetic variation was rs10046 in CYP19 (58).…”

Long non‐coding RNA LINC00261 inhibits cell growth and migration in endometriosis

“…The cause of endometriosis is multifactorial, including hormones, immunity, environment and multiple susceptible genes . Although the exact pathophysiological mechanism of endometriosis is still largely unclear, recent studies have focused on genetic factors …”

Relationship between MspI polymorphism of CYP1A1 gene and the risk of endometriosis in an Iranian population: A case-control study

“…The role of products of CYP1A1 gene in metabolism of estrogen and PAH has been well-defined (9, 17). It was observed that CYP1A1 was implicated in metabolism of dioxin, which may increase the severity of endometriosis in rhesus monkeys (18).…”

“…So far, the relationship between endometriosis and different genes has been investigated. Among them, genes involved in detoxification systems such as Cytochrome ( CYP ) P450 superfamily are the most important ones and possibly a good link for interactions of genetic and environmental factors (8, 9). Enzymes of this family are participated in detoxification process of a wide range of environmental pollutants and carcinogens (10).…”