Diosgenin: Chemistry, extraction, quantification and health benefits

Arya, Prajya; Munshi, Mohona; Kumar, Pradyuman

doi:10.1016/j.focha.2022.100170

Cited by 15 publications

(4 citation statements)

References 105 publications

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“…It is abundant in species such as Rhizoma polgonati, Smilax china, Dioscorea villosa, Trigonella foenum-graecum, Dioscorea zingibar-ensis, Dioscorea villosa, Solanum incanum, Solanum xantcarpum, among other species with medicinal values widely distributed around the world. [12][13][14][15] It originates mainly from dioscin saponin through the hydrolysis method, however, other methods of obtaining it have gained more attention, such as microbial transformation, which is a very specific method, are low cost and environmentally safe. [13] Diosgenin is a phytochemical that has gained prominence due to its usefulness in the treatment of various diseases, such as nervous system disorders [16] cardiovascular diseases, [17] cancer, [18,19] inflammation, [20] arthritis [21] and antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

“…Diosgenin (3β‐hydroxy‐5‐spirostene) is a naturally occurring steroidal sapogenin, belonging to the spirostane class, it has been found abundantly in species belonging to the families Rhamnaceae, Liliaceae, Scrophulariaceae, Dioscoreaceae, Amaryllidaceae, Solanaceae, Leguminosae, and Agavaceae. It is abundant in species such as Rhizoma polgonati , Smilax china , Dioscorea villosa , Trigonella foenum‐graecum , Dioscorea zingibarensis , Dioscorea villosa , Solanum incanum , Solanum xantcarpum , among other species with medicinal values widely distributed around the world [12–15] . It originates mainly from dioscin saponin through the hydrolysis method, however, other methods of obtaining it have gained more attention, such as microbial transformation, which is a very specific method, are low cost and environmentally safe [13] …”

Section: Introductionmentioning

confidence: 99%

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In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin

do Socorro Costa,

da Silva,

Santos Araújo

et al. 2024

Chemistry & Biodiversity

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Fungal infections are a public health problem that mainly affects immunosuppressed people, Candida spp. have been responsible for most sources of contamination and invasive fungal infections described around the world. The need arises to find new therapeutic approaches to combat growing infections. Plants and natural products have been considered a valuable source for discovering new molecules with active ingredients. Diosgenin is a sapogenin found in the families of Leguminosae and Dioscoreaceae, it is obtained mainly from the dioscin saponin through the hydrolysis method, it is a phytochemical that has been highlighted in the treatment of various diseases, as well as in combating microbial resistance. The present study aimed to evaluate the susceptibility of fungal strains to diosgenin, as well as verify the association with the reference drug and evaluate the inhibition of the virulence factor through morphological changes in the yeast state to the filamentous form of hyphae and pseudohyphae in strains of Candida albicans, Candida tropicalis and Candida krusei using the broth microdilution method and microculture technique. Antifungal assays revealed that diosgenin was not able to inhibit the growth of the tested strains.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin

do Socorro Costa,

da Silva,

Santos Araújo

et al. 2024

Chemistry & Biodiversity

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“…Standard analytical methods include spectrophotometry, gravimetry, or thin layer chromatography (TLC), and more advanced methods include immunoenzymatic assays (ELISAs), gas chromatography, liquid chromatography, and ultra-high performance liquid chromatography. 11 Nuclear Magnetic Resonance (NMR) is an alternative analytical method that can be very useful in the characterization of sapogenins and a wide range of natural products. Essentially, there are two reports dedicated to NMR analysis of 1a, but they are limited to only the description of the 1 H and 13 C chemical shifts 12,13 and do not contain the coupling constants, which remain unknown until now.…”

Section: Introductionmentioning

confidence: 99%

Complete ¹H NMR Assignment of Diosgenin Benzoate

Becerra‐Martínez

Bañuelos-Hernández

Pérez‐Hernández

et al. 2023

Natural Product Communications

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Diosgenin (1a) is used as a raw starting material for the synthesis of steroid hormones and contraceptives and is probably one of the most commercially important steroidal sapogenins. The literature on 1a is extensive, and topics range from its isolation from a variety of natural sources to its chemical modifications and therapeutic properties as an anti-cancer, anti-diabetic, anti-thrombosis, anti-inflammatory, and anti-viral agent, among others. 1 The spectroscopic characteristics of 1a have been analyzed for a long time, but the assignment of the complete 1H NMR profile remains incomplete due to the overlapping signals obtained with the most common spectrometers. In the current study, the 750-MHz 1H NMR spectrum of diosgenin benzoate (1b) has been completely assigned by means of QM-based 1H iterative full spin analysis (HiFSA), which is used for the complete 1H NMR description of intricate natural products and the quality control of pharmaceuticals. 2 The complete assignment was facilitated by taking advantage of some chemical shifts described for 1a and the coupling constants of the cholestane skeleton of cholesteryl benzoate, which were also recently calculated by HiFSA. 3

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“…Diosgenin is a steroidal aglycone compound that is produced through alternations in the chemical synthetic pathway. It aids in the production of various sex hormones, such as progesterone, estrogen, and steroidal drugs on an industrial level [ 2 ]. The medicinal properties of diosgenin aids in the prevention and treatment of various metabolic disorders, such as cancer, diabetes, cardiovascular disorder, obesity, hyperglycemia, blood and bone disorders, vasodilating effect, melanogenesis, and many others [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Carrier Agents on Quality Parameters of Spray-Dried Encapsulated Diosgenin Powder and the Optimization of Process Parameters

Arya

Kumar

2023

Foods

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Fenugreek seeds are a rich source of bioactive compounds, such as diosgenin, which is one of the most crucial steroidal sapogenins emerging in the field with its spectacular health benefits. Plant-based diosgenin is bitter in taste and has remarkably low consumption levels, making it unable to fulfil the role of improving health benefits. Diosgenin is spray dried to mask bitterness and astringent flavors with two different wall materials, such as maltodextrin (MD) and whey protein concentrate (WPC), separately. The spray-drying condition of the selected optimization process was inlet air temperature (IAT 150–170 °C), feed flow rate (FFR 300–500 mL/h), and carrier agent concentration (CAC 10–20%). The optimization of the process variable was conducted for producing optimized encapsulated diosgenin powder (EDP) with both MD and WPC. The selected parameters, such as yield, encapsulation efficiency, moisture content, antioxidant activity, hygroscopicity, and solubility, are investigated in this current work. Based on the experimental results, the significant R2 values depict the model fitting to the responses. EDP revealed an optimization condition at 170 °C IAT, 500 mL/h FFR, and 20% CAC for MD and WPC. The highest responses were observed with WPC-EDP, such as yield at 82.25%, encapsulation efficiency at 88.60%, antioxidant activity at 53.95%, and hygroscopicity at 12.64%. MD-EDP revealed higher solubility at 96.64% and moisture content at 2.58%. EDP was studied using micrographs and diffractograms for the optimized samples, which revealed a smooth and dented surface with an amorphous nature for MD-EDP and WPC-EDP, respectively. EDP exhibited acceptable powder properties with regard to fulfilling the set purpose. EDP can be a better potential ingredient in different food matrices to act as a delivery vehicle for various health aliments.

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Diosgenin: Chemistry, extraction, quantification and health benefits

Cited by 15 publications

References 105 publications

In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin

In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin

Complete ¹H NMR Assignment of Diosgenin Benzoate

Effect of Carrier Agents on Quality Parameters of Spray-Dried Encapsulated Diosgenin Powder and the Optimization of Process Parameters

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Diosgenin: Chemistry, extraction, quantification and health benefits

Cited by 15 publications

References 105 publications

In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin

In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin

Complete 1H NMR Assignment of Diosgenin Benzoate

Effect of Carrier Agents on Quality Parameters of Spray-Dried Encapsulated Diosgenin Powder and the Optimization of Process Parameters

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Product

Resources

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Complete ¹H NMR Assignment of Diosgenin Benzoate