Dioctyl sodium sulfosuccinate—An ineffective prophylactic laxative

Goodman, Jay I.; Pang, Jane Wan Lu; Bessman, Alice N.

doi:10.1016/0021-9681(76)90068-0

Cited by 19 publications

(6 citation statements)

References 3 publications

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“…Facile protocols for assessing DOSS exposure and results provided herein could significantly aid in understanding the contribution of DOSS exposure during pregnancy to child metabolism, obesity and overall health. Several studies have highlighted the ineffectiveness of Colace to treat constipation, thus suggesting an opportunity to reduce prescription or eliminate use of this medication during pregnancy 105,106 .…”

Section: Discussionmentioning

confidence: 99%

Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams

Temkin

Bowers

Ulmer

et al. 2019

Sci Rep

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Evidence indicates that obesity can be promoted by chemical ‘obesogens’ that drive adiposity, hunger, inflammation and suppress metabolism. Dioctyl sodium sulfosuccinate (DOSS), a lipid emulsifier and candidate obesogen in vitro, is widely used in processed foods, cosmetics and as stool softener medicines commonly used during pregnancy. In vivo testing of DOSS was performed in a developmental origins of adult obesity model. Pregnant mice were orally administered vehicle control or DOSS at times and doses comparable to stool softener use during human pregnancy. All weaned offspring consumed only standard diet. Adult male but not female offspring of DOSS-treated dams showed significantly increased body mass, overall and visceral fat masses, and decreased bone area. They exhibited significant decreases in plasma adiponectin and increases in leptin, glucose intolerance and hyperinsulinemia. Inflammatory IL-6 was elevated, as was adipose Cox2 and Nox4 gene expressions, which may be associated with promoter DNA methylation changes. Multiple significant phospholipid/sterol lipid increases paralleled profiles from long-term high-fat diet induced obesity in males. Collectively, developmental DOSS exposure leads to increased adult adiposity, inflammation, metabolic disorder and dyslipidemia in offspring fed a standard diet, suggesting that pharmaceutical and other sources of DOSS taken during human pregnancy might contribute to long-term obesity-related health concerns in offspring.

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Section: Discussionmentioning

confidence: 99%

Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams

Temkin

Bowers

Ulmer

et al. 2019

Sci Rep

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“…The initial trial in 1976 studied 34 elderly patients on a general medical ward for prophylaxis of constipation. 12 They random-ized patients to 100 mg twice daily of docusate sodium versus a control group that did not receive any type of laxative. The number of bowel movements and their character served as the measured outcomes.…”

Section: Why There Is No Reason To Prescribe Docusate For Constipationmentioning

confidence: 99%

Things We Do for No Reason: Prescribing Docusate for Constipation in Hospitalized Adults

Fakheri

Volpicelli

2019

Journal of Hospital Medicine

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The "Things We Do for No Reason" (TWDFNR) series reviews practices that have become common parts of hospital care but which may provide little value to our patients. Practices reviewed in the TWDFNR series do not represent "black and white" conclusions or clinical practice standards but are meant as a starting place for research and active discussions among hospitalists and patients. We invite you to be part of that discussion. CASE PRESENTATION An 80-year-old woman with no significant past medical history presents with a mechanical fall. X-rays are notable for a right hip fracture. She is treated with morphine for analgesia and evaluated by orthopedic surgery for surgical repair. The hospitalist recognizes that this patient is at high risk for constipation and orders docusate for prevention of constipation.

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“…Zudem sind in der Pädiatrie Fälle von Paraffinölaspi-ration mit nachfolgender Entwicklung einer Pneumonie beschrieben, da es häufig als mildes Laxans bei Kindern mit chronischer Obstipation angewandt wird (Bandla et al 1999). (Goodman et al 1976). Weitere Studien allerdings zeigten, dass DSS die Wasser-und Elektrolytsekretion im menschlichen Dünndarm sowie im Blinddarm der Ratte (Donowitz und Binder 1975) stimuliert und die Absorption von Glukose und Bikarbonat hemmt.…”

Section: Uaw Von Paraffinölunclassified

Laxatives in the horse – a review of the literature

Gembicki¹,

Fey²

2011

PHK

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ZusammenfassungPrimäre Obstipationen im Dickdarm des Pferdes verursachen häufig Kolikerscheinungen. Insbesondere Verstopfungen des Colon ascendens werden als eine der häufigsten Kolikursachen in der Pferdepopulation gesehen. Zu den empfohlenen Therapiemaßnahmen gehört in der Regel eine Abführtherapie, wobei je nach Herkunft und persönlicher Erfahrung der Autoren unterschiedliche Laxativa bevorzugt werden. Ziel dieser Übersicht ist es, die bislang beim Pferd publizierten Studienergebnisse zum Einsatz solcher laxierend wirkenden Substanzen zusammenzufassen und gegebenenfalls durch Untersuchungen an anderen Spezies zu ergänzen. Nach einer kurzen Vorstellung der jeweiligen Wirkstoffe wird insbesondere auf die messbaren therapeutischen Effekte beim Pferd und auf unerwünschte Arzneimittelwirkungen (UAW) eingegangen. Schwerpunkte bilden die Erkenntnisse zu Effekten von Glaubersalz (0,5-1 g/kg KGW) bzw. wasserfreiem Natriumsulfat, Bittersalz (Magnesiumsulfat; 0,2-1 g/kg KGW), Paraffinöl (0,5-10 ml/kg KGW), Natriumdioctylsulfosuccinat (DSS) und Quellstoffen.Schlüsselwörter: Pferd / Obstipation / Laxantien / Natriumsulfat / Magnesiumsulfat / Paraffinöl / Dioctylsulfosuccinat Laxatives in the horse -a review of the literature After spasmodic colics, primary impactions of the large colon and caecum are the most common causes of colic in horses. In many of these cases, laxatives are routinely used in the field to resolve the impaction. Laxatives with different mechanisms of action and molecular composition are mentioned in the relevant literature. In clinical studies, intravenous or enteral fluid therapy seems to have become increasingly popular. However, the traditional use of oral or intragastric laxatives seems to be efficient in many cases and require much less effort and incur much lower financial costs. It is the aim of this paper to give an overview and summarize the results of studies, which have measured the effect of oral or intragastric laxatives in the horse. Where appropriate, results of publications in other species were included. After an introduction of the different classes and individual substances of the laxatives used in the equine species, the reported therapeutic benefits and possible side effects in the horse are described. Most of the literature refers to sodium sulfate (0.5-1 g/kg), magnesium sulfate (Epsom salt; 0.2-1 g/kg), mineral oil (paraffin oil; 0.5-10 ml/kg), dioctyl sodium sulfosuccinate (DSS) and lubricants of plant origin.

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Dioctyl sodium sulfosuccinate—An ineffective prophylactic laxative

Cited by 19 publications

References 3 publications

Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams

Increased adiposity, inflammation, metabolic disruption and dyslipidemia in adult male offspring of DOSS treated C57BL/6 dams

Things We Do for No Reason: Prescribing Docusate for Constipation in Hospitalized Adults

Laxatives in the horse – a review of the literature

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